Gene · 116443
GRIN3A: glutamate ionotropic receptor NMDA type subunit 3A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GRIN3A: glutamate ionotropic receptor NMDA type subunit 3A. Genes, record 116443. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/116443
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8TCU5 | Glutamate receptor ionotropic, NMDA 3A | 1,115 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents20
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47786 | Q8TCU5 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8012 | Q8TCU5 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8125 | Q8TCU5 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1879 | Q8TCU5 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1879 | Q8TCU5 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8125 | Q8TCU5 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8012 | Q8TCU5 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 25 | Q8TCU5 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 35068 | Q8TCU5 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 5691 | Q8TCU5 | Espacenet |
1 to 10 of 20
See all 20 patentsDrugs28
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ACAMPROSATE | CHEMBL1201293 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| AMANTADINE | CHEMBL660 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| AMANTADINE HYDROCHLORIDE | CHEMBL1569 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| APIMOSTINEL | CHEMBL3989872 | Glutamate [NMDA] receptor partial agonist | PARTIAL AGONIST | ChEMBL |
| AV-101 | CHEMBL3545351 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| AZD8108 | CHEMBL3707355 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| CNS-5161 | CHEMBL41306 | Glutamate [NMDA] receptor blocker | BLOCKER | ChEMBL |
| DELUCEMINE | CHEMBL2110814 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| ESKETAMINE | CHEMBL395091 | Glutamate [NMDA] receptor negative allosteric modulator | NEGATIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 28
See all 28 drugsTrials838
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07603596 | ESKETAMINE | PHASE1 | ClinicalTrials.gov | |
| NCT07602153 | ESKETAMINE | ClinicalTrials.gov | ||
| NCT07597486 | ESKETAMINE | ClinicalTrials.gov | ||
| NCT07584902 | ESKETAMINE | ClinicalTrials.gov | ||
| NCT07573969 | KETAMINE | PHASE3 | ClinicalTrials.gov | |
| NCT07569198 | KETAMINE | PHASE2 | ClinicalTrials.gov | |
| NCT07564531 | KETAMINE | ClinicalTrials.gov | ||
| NCT07563296 | KETAMINE | PHASE2 | ClinicalTrials.gov | |
| NCT07560878 | MEMANTINE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07560722 | ESKETAMINE | ClinicalTrials.gov |
1 to 10 of 838
See all 838 trialsNIH grants898
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GRIN3A papers | Newest fiscal year |
|---|---|---|---|
| ZIAMH002857 | Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect | 6 | 2025 |
| R01HD082373 | NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted Therapy | 5 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 5 | 2025 |
| R35NS111619 | Glutamate receptors and human neurological disease | 4 | 2025 |
| ZIAMH002927 | Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders | 4 | 2025 |
| R01MH085926 | Structures and reagents of NMDA receptors | 3 | 2025 |
| R01NS097536 | Structural and functional investigation of allosteric NMDA receptor modulation | 3 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 3 | 2025 |
| ZIAMH002844 | Genetic Determinants of Antidepressant Response | 3 | 2025 |
| P30GM140963 | Biomolecular Structure and Dynamics | 2 | 2025 |
1 to 10 of 898Source NIH's project files
See all 898 nih grantsPapers850
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Structural and mechanistic insights into gating and allosteric modulation of GluN1-GluN3A NMDA receptors. | Nat Struct Mol Biol | 2026 | 42665662 | PubTator, text mining | PubMed |
| Integrating machine learning and retrospective cohort to explore the effects of AEDs on the prognosis of LGG and identify related molecular targets. | BMC Pharmacol Toxicol | 2026 | 42298735 | PubTator, text mining | PubMed |
| HOXD11-NMDAR signaling drives neuroendocrine prostate cancer and enables potential therapeutic intervention as a target of memantine. | Cell Rep | 2026 | 42126948 | PubTator, text mining | PubMed |
| Native architecture, allosteric modulation and gating mechanism of glycine-dependent NMDA receptors. | bioRxiv | 2026 | 42039402 | PubTator, text mining | PubMed |
| Corrigendum to "A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor" [Molecular Pharmacology 108 (2026) 100104]. | Mol Pharmacol | 2026 | 41916152 | PubTator, text mining | PubMed |
| Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes. | Clin Rev Allergy Immunol | 2026 | 41854785 | PubTator, text mining | PubMed |
| UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors. | Mol Pharmacol | 2026 | 41740201 | PubTator, text mining | PubMed |
| The Role of Disulfide Bonds in the GluN1 Subunit in the Early Trafficking and Functional Properties of GluN1/GluN2 and GluN1/GluN3 NMDA Receptors. | J Neurosci | 2026 | 41735054 | PubTator, text mining | PubMed |
| Genetic modifiers of APOE-ε4-associated cognitive decline. | Nat Commun | 2026 | 41720779 | PubTator, text mining | PubMed |
| A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor. | Mol Pharmacol | 2026 | 41713186 | PubTator, text mining | PubMed |
1 to 10 of 850
See all 850 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/116443
GET https://conductscience.org/api/genes/v1/116443/patents