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Gene · 116443

GRIN3A: glutamate ionotropic receptor NMDA type subunit 3A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GRIN3A: glutamate ionotropic receptor NMDA type subunit 3A. Genes, record 116443. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/116443

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Gene

Symbol
GRIN3A
HGNC
Name
glutamate ionotropic receptor NMDA type subunit 3A
HGNC
NCBI Gene ID
116443
NCBI Gene
HGNC ID
HGNC:16767
HGNC
Ensembl
ENSG00000198785
NCBI Gene
Aliases
GluN3A, NMDAR-L, NMDAR3A, NR3A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TCU5Glutamate receptor ionotropic, NMDA 3A1,1153Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447786Q8TCU5Espacenet
EP 4650780 A22025-11-198012Q8TCU5Espacenet
EP 4641201 A22025-10-298125Q8TCU5Espacenet
JP 2025529142 A2025-09-041879Q8TCU5Espacenet
US 12371689 B22025-07-291879Q8TCU5Espacenet
JP 2025517969 A2025-06-128125Q8TCU5Espacenet
JP 2025517970 A2025-06-128012Q8TCU5Espacenet
EP 4551941 A22025-05-1425Q8TCU5Espacenet
US 11446398 B22022-09-2035068Q8TCU5Espacenet
US 11400116 B22022-08-025691Q8TCU5Espacenet

1 to 10 of 20

See all 20 patents

Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACAMPROSATECHEMBL1201293Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINECHEMBL660Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINE HYDROCHLORIDECHEMBL1569Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
APIMOSTINELCHEMBL3989872Glutamate [NMDA] receptor partial agonistPARTIAL AGONISTChEMBL
AV-101CHEMBL3545351Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AZD8108CHEMBL3707355Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
CNS-5161CHEMBL41306Glutamate [NMDA] receptor blockerBLOCKERChEMBL
DELUCEMINECHEMBL2110814Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ESKETAMINECHEMBL395091Glutamate [NMDA] receptor negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 28

See all 28 drugs

Trials838

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants898

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGRIN3A papersNewest fiscal year
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect62025
R01HD082373NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted Therapy52025
R28AA012725Brain Tissue Resource Center for Alcohol Research52025
R35NS111619Glutamate receptors and human neurological disease42025
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders42025
R01MH085926Structures and reagents of NMDA receptors32025
R01NS097536Structural and functional investigation of allosteric NMDA receptor modulation32025
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025
ZIAMH002844Genetic Determinants of Antidepressant Response32025
P30GM140963Biomolecular Structure and Dynamics22025

1 to 10 of 898Source NIH's project files

See all 898 nih grants

Papers850

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural and mechanistic insights into gating and allosteric modulation of GluN1-GluN3A NMDA receptors.Nat Struct Mol Biol202642665662PubTator, text miningPubMed
Integrating machine learning and retrospective cohort to explore the effects of AEDs on the prognosis of LGG and identify related molecular targets.BMC Pharmacol Toxicol202642298735PubTator, text miningPubMed
HOXD11-NMDAR signaling drives neuroendocrine prostate cancer and enables potential therapeutic intervention as a target of memantine.Cell Rep202642126948PubTator, text miningPubMed
Native architecture, allosteric modulation and gating mechanism of glycine-dependent NMDA receptors.bioRxiv202642039402PubTator, text miningPubMed
Corrigendum to "A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor" [Molecular Pharmacology 108 (2026) 100104].Mol Pharmacol202641916152PubTator, text miningPubMed
Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes.Clin Rev Allergy Immunol202641854785PubTator, text miningPubMed
UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors.Mol Pharmacol202641740201PubTator, text miningPubMed
The Role of Disulfide Bonds in the GluN1 Subunit in the Early Trafficking and Functional Properties of GluN1/GluN2 and GluN1/GluN3 NMDA Receptors.J Neurosci202641735054PubTator, text miningPubMed
Genetic modifiers of APOE-ε4-associated cognitive decline.Nat Commun202641720779PubTator, text miningPubMed
A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor.Mol Pharmacol202641713186PubTator, text miningPubMed

1 to 10 of 850

See all 850 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/116443

GET https://conductscience.org/api/genes/v1/116443/patents