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Gene · 116444

GRIN3B: glutamate ionotropic receptor NMDA type subunit 3B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GRIN3B: glutamate ionotropic receptor NMDA type subunit 3B. Genes, record 116444. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/116444

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Gene

Symbol
GRIN3B
HGNC
Name
glutamate ionotropic receptor NMDA type subunit 3B
HGNC
NCBI Gene ID
116444
NCBI Gene
HGNC ID
HGNC:16768
HGNC
Ensembl
ENSG00000116032
NCBI Gene
Aliases
GluN3B, NR3B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60391Glutamate receptor ionotropic, NMDA 3B1,0430Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19886O60391Espacenet
EP 4641201 A22025-10-29624O60391Espacenet
JP 2025529142 A2025-09-041880O60391Espacenet
US 12371689 B22025-07-291880O60391Espacenet
JP 2025517969 A2025-06-12624O60391Espacenet
JP 2025517970 A2025-06-12886O60391Espacenet
EP 4551941 A22025-05-1426O60391Espacenet
KR 1020250036291 A2025-03-141O60391Espacenet
US 11446398 B22022-09-2035069O60391Espacenet
US 11400116 B22022-08-025769O60391Espacenet

1 to 10 of 19

See all 19 patents

Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACAMPROSATECHEMBL1201293Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINECHEMBL660Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINE HYDROCHLORIDECHEMBL1569Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
APIMOSTINELCHEMBL3989872Glutamate [NMDA] receptor partial agonistPARTIAL AGONISTChEMBL
AV-101CHEMBL3545351Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AZD8108CHEMBL3707355Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
CNS-5161CHEMBL41306Glutamate [NMDA] receptor blockerBLOCKERChEMBL
DELUCEMINECHEMBL2110814Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ESKETAMINECHEMBL395091Glutamate [NMDA] receptor negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 28

See all 28 drugs

Trials838

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants562

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGRIN3B papersNewest fiscal year
R28AA012725Brain Tissue Resource Center for Alcohol Research52025
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect52025
R01HD082373NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted Therapy42025
R35NS111619Glutamate receptors and human neurological disease42025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)42025
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders42025
R01NS097536Structural and functional investigation of allosteric NMDA receptor modulation32025
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions22025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study22025

1 to 10 of 562Source NIH's project files

See all 562 nih grants

Papers512

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes.Clin Rev Allergy Immunol202641854785PubTator, text miningPubMed
UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors.Mol Pharmacol202641740201PubTator, text miningPubMed
A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor.Mol Pharmacol202641713186PubTator, text miningPubMed
NLRP3-mediated neuroinflammation in the ventrolateral orbital cortex contributes to the formation of morphine-induced addiction memory by upregulating GRIN3B.Prog Neurobiol202641401853PubTator, text miningPubMed
Emerging Roles of GluN3B NMDA Receptor Subunit in the Central Nervous System.Neurosci Bull202641139355PubTator, text miningPubMed
Prioritizing missense mutations via a deep learning phosphorylation prediction model.Hum Genomics202541469746PubTator, text miningPubMed
UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors.bioRxiv202541292873PubTator, text miningPubMed
Trisomy 21 Disrupts Thyroid Hormones Signaling During Human iPSC-Derived Neural Differentiation In Vitro.Cells202541002374PubTator, text miningPubMed
Osteopontin derived from hypoxia-induced M2 macrophages promotes osteosarcoma progression through modulation of EGR3/ISG15 signaling and RIG-I expression.J Transl Med202540841904PubTator, text miningPubMed
Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the All of Us Research Program.Ophthalmol Sci202540837069PubTator, text miningPubMed

1 to 10 of 512

See all 512 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/116444

GET https://conductscience.org/api/genes/v1/116444/patents