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Gene · 116844

LRG1: leucine rich alpha-2-glycoprotein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LRG1: leucine rich alpha-2-glycoprotein 1. Genes, record 116844. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/116844

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Gene

Symbol
LRG1
HGNC
Name
leucine rich alpha-2-glycoprotein 1
HGNC
NCBI Gene ID
116844
NCBI Gene
HGNC ID
HGNC:29480
HGNC
Ensembl
ENSG00000171236
NCBI Gene
Aliases
HMFT1766, LRG
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P02750Leucine-rich alpha-2-glycoprotein3472Ensembl, GeneID, HGNC

Source UniProt

Patents102

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025172069 A2025-11-20522P02750Espacenet
EP 4650780 A22025-11-194152P02750Espacenet
JP 2025147176 A2025-10-068003P02750Espacenet
JP 2025138725 A2025-09-252062P02750Espacenet
JP 2025529142 A2025-09-046920P02750Espacenet
JP 2025118850 A2025-08-132P02750Espacenet
US 12371689 B22025-07-296920P02750Espacenet
EP 4587839 A22025-07-2348P02750Espacenet
JP 2025517970 A2025-06-124152P02750Espacenet
EP 4549941 A12025-05-0712P02750Espacenet

1 to 10 of 102

See all 102 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants778

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLRG1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
P30CA045508CSHL Cancer Center Support Grant52025
U01CA200468Clinical Validation Center for Early Detection of Pancreatic Cancer52025
P01CA013106Targeting Transcription and Splicing in Cancer42025
P30CA008748Cancer Center Support Grant32025
P30CA014520UW Comprehensive Cancer Center Support32025
P30CA006973Regional Oncology Research Center22025
P30CA043703Case Comprehensive Cancer Center Support Grant22025
R01CA222349Non-canonical Caspase-8 Activation on Autophagosomal Membranes22025
R01CA254036Urine and serum biomarkers for early diagnosis and risk assessment of pancreatic cancer22025

1 to 10 of 778Source NIH's project files

See all 778 nih grants

Papers1,817

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Maternal cardiovascular, endothelial and inflammatory biomarker dysregulation in twin-twin transfusion syndrome: insights into shared mechanisms with pre-eclampsia.Placenta202642801806PubTator, text miningPubMed
Diagnostic Performance of Serum Leucine-Rich Alpha-2-Glycoprotein 1 and Plasma Calprotectin in Adults with Suspected Acute Appendicitis: A Cross-Sectional Observational Study.Biomedicines202642792764PubTator, text miningPubMed
EVA1B promotes non-small cell lung cancer progression through an LRG1-associated mechanism.3 Biotech202642781045PubTator, text miningPubMed
Evaluation of GCF levels of leucine-rich alpha-2 glycoprotein and TNF-α in stage III periodontitis patients: A case-control study.J Oral Biol Craniofac Res202642775077PubTator, text miningPubMed
Leucine-rich alpha-2 glycoprotein as a predictor of primary non-response to anti-TNF-α therapy in biologic-naïve Egyptian IBD patients.BMC Gastroenterol202642760552PubTator, text miningPubMed
Serum amyloid a as a high-resolution indicator of mucosal healing in ulcerative colitis.Crohns Colitis 360202642732310PubTator, text miningPubMed
Anti-TNF therapy attenuates the diagnostic utility of leucine-rich α2-Glycoprotein 1 for endoscopic activity in ulcerative colitis.Ther Adv Gastroenterol202642729529PubTator, text miningPubMed
Serum Leucine-Rich α2-Glycoprotein 1 Identifies Cachexia in Patients With Liver Cirrhosis and/or Hepatocellular Carcinoma Having Low C-Reactive Protein Levels.Hepatol Res202642723464PubTator, text miningPubMed
Plasma protein profile in patients with antiphospholipid syndrome and controls without antiphospholipid syndrome.J Thromb Haemost202642674367PubTator, text miningPubMed
Polyp Tissue LRG1 Protein Levels and Helicobacter pylori Infection as Independent Predictors for Colonic Polyp Recurrence.Int J Gen Med202642631196PubTator, text miningPubMed

1 to 10 of 1,817

See all 1,817 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/116844

GET https://conductscience.org/api/genes/v1/116844/patents?page=2