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ADCYAP1R1: ADCYAP receptor type I

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADCYAP1R1: ADCYAP receptor type I. Genes, record 117. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/117

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Gene

Symbol
ADCYAP1R1
HGNC
Name
ADCYAP receptor type I
HGNC
NCBI Gene ID
117
NCBI Gene
HGNC ID
HGNC:242
HGNC
Ensembl
ENSG00000078549
NCBI Gene
Aliases
PAC1, PAC1R, PACAPR, PACAPRI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41586Pituitary adenylate cyclase-activating polypeptide type I receptor46811Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436711P41586Espacenet
EP 4650780 A22025-11-194431P41586Espacenet
JP 2025147176 A2025-10-06407P41586Espacenet
JP 2025529142 A2025-09-04295P41586Espacenet
JP 2025529142 A2025-09-045407P41586Espacenet
US 12371689 B22025-07-29295P41586Espacenet
US 12371689 B22025-07-295407P41586Espacenet
JP 2025517970 A2025-06-124431P41586Espacenet
JP 2025062604 A2025-04-142838P41586Espacenet
JP 2025032204 A2025-03-1124093P41586Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,151

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADCYAP1R1 papersNewest fiscal year
ZIADK053101Cellular Basis Of Action Of Gastrointestinal Peptides/Growth factors112025
ZIAMH002386Chemical Coding of Neurotransmission112025
R01MH108665Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala Pathways82025
ZIADK053100Characterization And Pharmacology Of Receptors For Gastrointestinal Peptides62025
T32MH020030ResearchTraining: Psychiatric and Statistical Genetics52025
P51OD011132Emory National Primate Research Center42025
R01HL131836Structural Transition of Cellular Integrins and Applications Thereof42025
UL1TR001863Yale Clinical and Translational Science Award42025
K12HD052892Molecular Basis of Pediatric Disease32025
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI32025

1 to 10 of 1,151Source NIH's project files

See all 1,151 nih grants

Papers1,829

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural basis of β-arrestin coupling and transducer selectivity in PAC1R.Acta Pharmacol Sin202642706324PubTator, text miningPubMed
Substance P and PACAP activate dural mast cells through MRGPRX2, not NK1R or PAC1/VPAC receptors.Cephalalgia202642627518PubTator, text miningPubMed
Pituitary adenylate cyclase-activating polypeptide and mitochondrial homeostasis in neuronal injury: mechanisms and translational prospects.Front Immunol202642614376PubTator, text miningPubMed
Diabetes Type 2: Circulating Phosphatidylserine-Expressing Platelets Regulate Whole Blood Agonist-Evoked Platelet Activity In Vitro.TH Open202642592371PubTator, text miningPubMed
[Pituitary adenylate-cyclase activating polypeptide (PACAP)-targeting treatment as a potential migraine prophylactic therapy].Ideggyogy Sz202642554332PubTator, text miningPubMed
Methodological Considerations in Platelet Flow Cytometric Studies.Int J Lab Hematol202642464905PubTator, text miningPubMed
Diabetes type 2: magnitudes of agonist-evoked platelet activity markers in vitro demonstrate a substantial individual dependence.Blood Coagul Fibrinolysis202642130232PubTator, text miningPubMed
The pituitary adenylate cyclase-activating polypeptide receptor and its splice variants: Unique roles in affective and motivated behavior.J Neuroendocrinol202641980614PubTator, text miningPubMed
Novel small-molecule positive allosteric modulator 1 with blood-brain barrier penetration activity exerts anti-cellular senescence effects via the PAC1-R/YY1/SIRT6 pathway.Acta Biochim Biophys Sin (Shanghai)202641863098PubTator, text miningPubMed
Impact of recalcification on procoagulant collagen-and-thrombin-activated (COAT) platelet generation in platelet-rich plasma samples with low platelet counts.Res Pract Thromb Haemost202641810334PubTator, text miningPubMed

1 to 10 of 1,829

See all 1,829 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/117

GET https://conductscience.org/api/genes/v1/117/patents?page=2