Gene · 117581
TWIST2: twist family bHLH transcription factor 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TWIST2: twist family bHLH transcription factor 2. Genes, record 117581. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/117581
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8WVJ9 | Twist-related protein 2 | 160 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68753 | Q8WVJ9 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 13326 | Q8WVJ9 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15817 | Q8WVJ9 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 13326 | Q8WVJ9 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15817 | Q8WVJ9 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15817 | Q8WVJ9 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15656 | Q8WVJ9 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 94186 | Q8WVJ9 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 94187 | Q8WVJ9 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 197157 | Q8WVJ9 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,133
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TWIST2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 17 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 6 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P20GM103475 | Advancing Competitive Biomedical Research in Puerto Rico | 4 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 4 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 4 | 2025 |
| P50CA058223 | SPORE in Breast Cancer | 4 | 2025 |
| U01CA200466 | Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma | 4 | 2025 |
| U01CA210240 | Pancreatic Cancer Detection Consortium | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,133Source NIH's project files
See all 1,133 nih grantsPapers1,990
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genetic and regenerative contexts specify distinct soft tissue sarcoma identities from Twist2+ progenitors. | Proc Natl Acad Sci U S A | 2026 | 42789298 | PubTator, text mining | PubMed |
| TWIST2-dependent transcriptional activation of TPI1 mediates TGF-β1-driven fibroblast activation in pulmonary fibrosis. | Cell Signal | 2026 | 42632531 | PubTator, text mining | PubMed |
| Local growth hormone promotes benign prostatic hyperplasia. | JCI Insight | 2026 | 42518286 | PubTator, text mining | PubMed |
| Adult TWIST2-high B-ALL confirms metabolic association but reveals molecular heterogeneity. | Hemasphere | 2026 | 42325849 | PubTator, text mining | PubMed |
| An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity. | Cell Press Blue | 2026 | 42147490 | PubTator, text mining | PubMed |
| Identification of MYMK, TWIST2, and NEDD4L as Key Susceptibility Genes for Nonsyndromic Orofacial Clefts Through Insights From Syndromic Cases. | Cleft Palate Craniofac J | 2026 | 42080994 | PubTator, text mining | PubMed |
| TWIST2 high expression defines a novel subtype of B-cell precursor acute lymphoblastic leukemia. | Hemasphere | 2026 | 41948570 | PubTator, text mining | PubMed |
| Overcoming Regorafenib Resistance in Colorectal Cancer: Synergistic Efficacy of Cilengitide in HT29 and WiDr Cells. | Medeni Med J | 2026 | 41906550 | PubTator, text mining | PubMed |
| Kynurenine Pathway, Nrf2 and NF-κB Cross-Regulation in the CNS: An Overview. | Mol Neurobiol | 2026 | 41894093 | PubTator, text mining | PubMed |
| Oxidative Stress and the KEAP1/NRF2 Axis in Saphenous Vein: Implications for Graft Patency. | Cells | 2026 | 41892352 | PubTator, text mining | PubMed |
1 to 10 of 1,990
See all 1,990 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/117581
GET https://conductscience.org/api/genes/v1/117581/patents?page=2