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Gene · 117581

TWIST2: twist family bHLH transcription factor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TWIST2: twist family bHLH transcription factor 2. Genes, record 117581. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/117581

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Gene

Symbol
TWIST2
HGNC
Name
twist family bHLH transcription factor 2
HGNC
NCBI Gene ID
117581
NCBI Gene
HGNC ID
HGNC:20670
HGNC
Ensembl
ENSG00000233608
NCBI Gene
Aliases
AMS, BBRSAY, DERMO1, Dermo-1, FFDD3, SETLSS, bHLHa39
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8WVJ9Twist-related protein 21600Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468753Q8WVJ9Espacenet
EP 4650780 A22025-11-1913326Q8WVJ9Espacenet
JP 2025147176 A2025-10-0615817Q8WVJ9Espacenet
JP 2025517970 A2025-06-1213326Q8WVJ9Espacenet
JP 2025028160 A2025-02-2815817Q8WVJ9Espacenet
KR 1020250010750 A2025-01-2115817Q8WVJ9Espacenet
JP 2024109657 A2024-08-1415656Q8WVJ9Espacenet
US 11446398 B22022-09-2094186Q8WVJ9Espacenet
US 11446398 B22022-09-2094187Q8WVJ9Espacenet
JP 2022524081 A2022-04-27197157Q8WVJ9Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,133

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTWIST2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
P30CA016058Cancer Center Support Grant62025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P20GM103475Advancing Competitive Biomedical Research in Puerto Rico42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025
P30CA046934University of Colorado Cancer Center Support Grant42025
P50CA058223SPORE in Breast Cancer42025
U01CA200466Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma42025
U01CA210240Pancreatic Cancer Detection Consortium42025
P30CA008748Cancer Center Support Grant32025

1 to 10 of 1,133Source NIH's project files

See all 1,133 nih grants

Papers1,990

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic and regenerative contexts specify distinct soft tissue sarcoma identities from Twist2+ progenitors.Proc Natl Acad Sci U S A202642789298PubTator, text miningPubMed
TWIST2-dependent transcriptional activation of TPI1 mediates TGF-β1-driven fibroblast activation in pulmonary fibrosis.Cell Signal202642632531PubTator, text miningPubMed
Local growth hormone promotes benign prostatic hyperplasia.JCI Insight202642518286PubTator, text miningPubMed
Adult TWIST2-high B-ALL confirms metabolic association but reveals molecular heterogeneity.Hemasphere202642325849PubTator, text miningPubMed
An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity.Cell Press Blue202642147490PubTator, text miningPubMed
Identification of MYMK, TWIST2, and NEDD4L as Key Susceptibility Genes for Nonsyndromic Orofacial Clefts Through Insights From Syndromic Cases.Cleft Palate Craniofac J202642080994PubTator, text miningPubMed
TWIST2 high expression defines a novel subtype of B-cell precursor acute lymphoblastic leukemia.Hemasphere202641948570PubTator, text miningPubMed
Overcoming Regorafenib Resistance in Colorectal Cancer: Synergistic Efficacy of Cilengitide in HT29 and WiDr Cells.Medeni Med J202641906550PubTator, text miningPubMed
Kynurenine Pathway, Nrf2 and NF-κB Cross-Regulation in the CNS: An Overview.Mol Neurobiol202641894093PubTator, text miningPubMed
Oxidative Stress and the KEAP1/NRF2 Axis in Saphenous Vein: Implications for Graft Patency.Cells202641892352PubTator, text miningPubMed

1 to 10 of 1,990

See all 1,990 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/117581

GET https://conductscience.org/api/genes/v1/117581/patents?page=2