Gene · 1181
CLCN2: chloride voltage-gated channel 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CLCN2: chloride voltage-gated channel 2. Genes, record 1181. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1181
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P51788 | Chloride channel protein 2 | 898 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 41141 | P51788 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2084 | P51788 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 964 | P51788 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 964 | P51788 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2084 | P51788 | Espacenet |
| JP 2024503719 A | 2024-01-26 | 146 | P51788 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 14893 | P51788 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3033 | P51788 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 117864 | P51788 | Espacenet |
| KR 1020210090594 A | 2021-07-20 | 3 | P51788 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials29
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06543979 | LUBIPROSTONE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05768334 | LUBIPROSTONE | PHASE3 | ClinicalTrials.gov | |
| NCT04985669 | LUBIPROSTONE | PHASE4 | ClinicalTrials.gov | |
| NCT03097861 | LUBIPROSTONE | PHASE3 | 2020-01-14 | ClinicalTrials.gov |
| NCT02729909 | LUBIPROSTONE | PHASE3 | 2019-04-01 | ClinicalTrials.gov |
| NCT02695719 | LUBIPROSTONE | PHASE3 | 2018-12-31 | ClinicalTrials.gov |
| NCT02651155 | LUBIPROSTONE | PHASE3 | 2018-08-13 | ClinicalTrials.gov |
| NCT02544152 | LUBIPROSTONE | PHASE2 | 2019-12-27 | ClinicalTrials.gov |
| NCT01993875 | LUBIPROSTONE | PHASE3 | 2019-12-13 | ClinicalTrials.gov |
| NCT01839734 | LUBIPROSTONE | PHASE2 | 2023-08-30 | ClinicalTrials.gov |
1 to 10 of 29
See all 29 trialsNIH grants558
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CLCN2 papers | Newest fiscal year |
|---|---|---|---|
| U54GM115428 | Mississippi Center for Clinical and Translational Research | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30DK034987 | Center for Gastrointestinal Biology and Disease | 3 | 2025 |
| R01DK043140 | Mechanisms Leading to Adrenal Zonation | 3 | 2025 |
| ZIAAI000882 | Cellular and Molecular Physiology of Bloodstream Malaria Parasites | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 2 | 2025 |
| P50CA186781 | Mayo Clinic Multiple Myeloma SPORE | 2 | 2025 |
| P51OD011092 | Support for National Primate Research Center | 2 | 2025 |
| R01DK044003 | Molecular Genetics of Cystic Fibrosis | 2 | 2025 |
| R01DK051610 | Structure-function analysis of the volume-regulated anion channel VRAC using novel LRRC8 chimeras | 2 | 2025 |
1 to 10 of 558Source NIH's project files
See all 558 nih grantsPapers1,076
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Novel gain-of-function CLCN2 germline mutation associated with nonclassical lateralizing primary aldosteronism. | J Mol Endocrinol | 2026 | 42439370 | PubTator, text mining | PubMed |
| Electrolyte Homeostasis in Sperm Biology and Channelopathies in Male Infertility: A Scoping Review. | Andrology | 2026 | 42095740 | PubTator, text mining | PubMed |
| CLCN2-related leukoencephalopathy with a mild presentation and prominent facial pain: diagnostic value of MRI pattern recognition. | Acta Neurol Belg | 2026 | 42020641 | PubTator, text mining | PubMed |
| CRISPR and Beyond: Genome-Editing Strategies in Retinal Stem Cell Research. | Cells | 2026 | 41892280 | PubTator, text mining | PubMed |
| Primary Hyperaldosteronism: Epidemiology, Diagnosis, and Clinical Associations. | Epidemiologia (Basel) | 2026 | 41873981 | PubTator, text mining | PubMed |
| Increased Frequency and Distinct Genotypic Patterns of Somatic Aldosterone-Driver Mutations in Aldosterone-Producing Micronodules from Primary Aldosteronism Patients. | Endocr Pathol | 2026 | 41857472 | PubTator, text mining | PubMed |
| Identification of a novel CLCN2 homozygous variant in a man with leukoencephalopathy and infertility: a case report and literature review. | Front Genet | 2026 | 41822756 | PubTator, text mining | PubMed |
| Association of avian biodiversity and West Nile Virus circulation in Culex mosquitoes in Emilia-Romagna, Italy. | PLoS Negl Trop Dis | 2026 | 41790846 | PubTator, text mining | PubMed |
| Molecular pathology of primary aldosteronism and hypercortisolism: Impact on adrenal surgery. | iScience | 2026 | 41736857 | PubTator, text mining | PubMed |
| CRISPR screening redefines therapeutic target identification and drug discovery with precision and scalability. | J Pharm Anal | 2026 | 41732321 | PubTator, text mining | PubMed |
1 to 10 of 1,076
See all 1,076 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1181
GET https://conductscience.org/api/genes/v1/1181/patents