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Gene · 1181

CLCN2: chloride voltage-gated channel 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CLCN2: chloride voltage-gated channel 2. Genes, record 1181. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1181

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Gene

Symbol
CLCN2
HGNC
Name
chloride voltage-gated channel 2
HGNC
NCBI Gene ID
1181
NCBI Gene
HGNC ID
HGNC:2020
HGNC
Ensembl
ENSG00000114859
NCBI Gene
Aliases
CIC-2, CLC2, ClC-2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, FHA2, FHII, HALD2, LKPAT, clC-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51788Chloride channel protein 28988Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441141P51788Espacenet
EP 4641201 A22025-10-292084P51788Espacenet
JP 2025529142 A2025-09-04964P51788Espacenet
US 12371689 B22025-07-29964P51788Espacenet
JP 2025517969 A2025-06-122084P51788Espacenet
JP 2024503719 A2024-01-26146P51788Espacenet
US 11446398 B22022-09-2014893P51788Espacenet
US 11400116 B22022-08-023033P51788Espacenet
JP 2022524081 A2022-04-27117864P51788Espacenet
KR 1020210090594 A2021-07-203P51788Espacenet

1 to 10 of 19

See all 19 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COBIPROSTONECHEMBL2103799Chloride channel protein 2 activatorACTIVATORChEMBL
LUBIPROSTONECHEMBL1201134Chloride channel protein 2 openerOPENERChEMBL

Trials29

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06543979LUBIPROSTONEPHASE1/PHASE2ClinicalTrials.gov
NCT05768334LUBIPROSTONEPHASE3ClinicalTrials.gov
NCT04985669LUBIPROSTONEPHASE4ClinicalTrials.gov
NCT03097861LUBIPROSTONEPHASE32020-01-14ClinicalTrials.gov
NCT02729909LUBIPROSTONEPHASE32019-04-01ClinicalTrials.gov
NCT02695719LUBIPROSTONEPHASE32018-12-31ClinicalTrials.gov
NCT02651155LUBIPROSTONEPHASE32018-08-13ClinicalTrials.gov
NCT02544152LUBIPROSTONEPHASE22019-12-27ClinicalTrials.gov
NCT01993875LUBIPROSTONEPHASE32019-12-13ClinicalTrials.gov
NCT01839734LUBIPROSTONEPHASE22023-08-30ClinicalTrials.gov

1 to 10 of 29

See all 29 trials

NIH grants558

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCLCN2 papersNewest fiscal year
U54GM115428Mississippi Center for Clinical and Translational Research72025
P30CA008748Cancer Center Support Grant32025
P30DK034987Center for Gastrointestinal Biology and Disease32025
R01DK043140Mechanisms Leading to Adrenal Zonation32025
ZIAAI000882Cellular and Molecular Physiology of Bloodstream Malaria Parasites32025
P30CA068485Cancer Center Support Grant22025
P50CA186781Mayo Clinic Multiple Myeloma SPORE22025
P51OD011092Support for National Primate Research Center22025
R01DK044003Molecular Genetics of Cystic Fibrosis22025
R01DK051610Structure-function analysis of the volume-regulated anion channel VRAC using novel LRRC8 chimeras22025

1 to 10 of 558Source NIH's project files

See all 558 nih grants

Papers1,076

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Novel gain-of-function CLCN2 germline mutation associated with nonclassical lateralizing primary aldosteronism.J Mol Endocrinol202642439370PubTator, text miningPubMed
Electrolyte Homeostasis in Sperm Biology and Channelopathies in Male Infertility: A Scoping Review.Andrology202642095740PubTator, text miningPubMed
CLCN2-related leukoencephalopathy with a mild presentation and prominent facial pain: diagnostic value of MRI pattern recognition.Acta Neurol Belg202642020641PubTator, text miningPubMed
CRISPR and Beyond: Genome-Editing Strategies in Retinal Stem Cell Research.Cells202641892280PubTator, text miningPubMed
Primary Hyperaldosteronism: Epidemiology, Diagnosis, and Clinical Associations.Epidemiologia (Basel)202641873981PubTator, text miningPubMed
Increased Frequency and Distinct Genotypic Patterns of Somatic Aldosterone-Driver Mutations in Aldosterone-Producing Micronodules from Primary Aldosteronism Patients.Endocr Pathol202641857472PubTator, text miningPubMed
Identification of a novel CLCN2 homozygous variant in a man with leukoencephalopathy and infertility: a case report and literature review.Front Genet202641822756PubTator, text miningPubMed
Association of avian biodiversity and West Nile Virus circulation in Culex mosquitoes in Emilia-Romagna, Italy.PLoS Negl Trop Dis202641790846PubTator, text miningPubMed
Molecular pathology of primary aldosteronism and hypercortisolism: Impact on adrenal surgery.iScience202641736857PubTator, text miningPubMed
CRISPR screening redefines therapeutic target identification and drug discovery with precision and scalability.J Pharm Anal202641732321PubTator, text miningPubMed

1 to 10 of 1,076

See all 1,076 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1181

GET https://conductscience.org/api/genes/v1/1181/patents