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CLU: clusterin

1 protein, 221 patents, 2 drugs, 9 trials, 5,591 NIH grants and 9,461 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCLUHGNC
NameclusterinHGNC
NCBI Gene ID1191NCBI Gene
HGNC IDHGNC:2095HGNC
EnsemblENSG00000120885NCBI Gene
AliasesAAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P10909Clusterin4492Ensembl, GeneID, HGNCUniProt

Patents 221

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441683P10909Espacenet
JP 2026004568 A2026-01-1441685P10909Espacenet
JP 2026004568 A2026-01-1441687P10909Espacenet
WO 2025262255 A12025-12-2640P10909Espacenet
EP 4650780 A22025-11-194997P10909Espacenet
EP 4641203 A22025-10-29160P10909Espacenet
JP 2025147176 A2025-10-063073P10909Espacenet
JP 2025147176 A2025-10-063074P10909Espacenet
JP 2025147176 A2025-10-063075P10909Espacenet
JP 2025529142 A2025-09-045911P10909Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CUSTIRSENCHEMBL2108309Clusterin mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
CUSTIRSEN SODIUMCHEMBL2219773Clusterin mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01630733CUSTIRSENPHASE3ClinicalTrials.gov
NCT01578655CUSTIRSENPHASE3ClinicalTrials.gov
NCT01188187CUSTIRSENPHASE3ClinicalTrials.gov
NCT00327340CUSTIRSENPHASE22012-08-29ClinicalTrials.gov
NCT00258388CUSTIRSEN SODIUMPHASE2ClinicalTrials.gov
NCT00258375CUSTIRSEN SODIUMPHASE2ClinicalTrials.gov
NCT00138918CUSTIRSEN SODIUMPHASE2ClinicalTrials.gov
NCT00138658CUSTIRSENPHASE1/PHASE22012-01-10ClinicalTrials.gov
NCT00054106CUSTIRSEN SODIUMPHASE1ClinicalTrials.gov

NIH grants 5591

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)1222,025NIH's project files
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions262,025NIH's project files
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study262,025NIH's project files
P30CA008748Cancer Center Support Grant212,025NIH's project files
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center162,025NIH's project files
P30DK017047Diabetes Research Center162,025NIH's project files
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)162,025NIH's project files
U24AG056270National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)162,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases152,025NIH's project files
R01NS017950Precursors of Stroke Incidence and Prognosis152,025NIH's project files

Papers 9461

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825454PubTator, text miningPubMed
42824315PubTator, text miningPubMed
42818647PubTator, text miningPubMed
42805281PubTator, text miningPubMed
42795286PubTator, text miningPubMed
42793402PubTator, text miningPubMed
42783847PubTator, text miningPubMed
42778607PubTator, text miningPubMed
42762600PubTator, text miningPubMed
42744164PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license