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Gene · 1195

CLK1: CDC like kinase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CLK1: CDC like kinase 1. Genes, record 1195. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1195

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Gene

Symbol
CLK1
HGNC
Name
CDC like kinase 1
HGNC
NCBI Gene ID
1195
NCBI Gene
HGNC ID
HGNC:2068
HGNC
Ensembl
ENSG00000013441
NCBI Gene
Aliases
CLK, CLK/STY, STY
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49759Dual specificity protein kinase CLK148438Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440724P49759Espacenet
EP 4650780 A22025-11-195690P49759Espacenet
EP 4641201 A22025-10-295347P49759Espacenet
JP 2025529142 A2025-09-041019P49759Espacenet
US 12371689 B22025-07-291019P49759Espacenet
JP 2025517969 A2025-06-125347P49759Espacenet
JP 2025517970 A2025-06-125690P49759Espacenet
JP 2025032204 A2025-03-1126474P49759Espacenet
EP 4461818 A22024-11-1326474P49759Espacenet
JP 2023058610 A2023-04-2526474P49759Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,222

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCLK1 papersNewest fiscal year
P40OD010440Caenorhabditis Genetics Center72025
P30CA008748Cancer Center Support Grant62025
R01HL128239Genetic and molecular basis for SRSF2 mutations in myelodysplasia62025
P30CA014051Cancer Center Support (Core) Grant42025
P30CA016672Cancer Center Support Grant42025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)42025
P01CA013106Targeting Transcription and Splicing in Cancer32025
P30CA015704Cancer Center Support Grant32025
P30CA034196Cancer Center Support (CORE) Grant32025
P30DK020593Vanderbilt Diabetes Research Center32025

1 to 10 of 1,222Source NIH's project files

See all 1,222 nih grants

Papers1,704

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mesoscale proximity labeling at chromatin leads to identification of small molecule mechanism of action.Nat Commun202642773171PubTator, text miningPubMed
Decoding the off-target potency of DB18: A comparative structural study of CLK1 and TRK kinases.Comput Biol Chem202642748630PubTator, text miningPubMed
A recurrently perturbed 12-gene program marks drug-tolerant persister states across cancer types.Front Bioinform202642682804PubTator, text miningPubMed
Thermo-sensing mechanisms of splicing control by nuclear stress bodies.Mol Cell202642462707PubTator, text miningPubMed
PERK orchestrates an endoplasmic reticulum stress alternative splicing program via CLK1/SRSF1.Nat Commun202642321166PubTator, text miningPubMed
Comprehensive proteogenomic characterization reveals clinically relevant molecular subtypes associated with medulloblastoma progression.Exp Mol Med202642249086PubTator, text miningPubMed
Differential Host Gene Expression Associated with Non-Lactobacillus-dominant Vaginal Microbiomes During Pregnancy.Res Sq202642245806PubTator, text miningPubMed
Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.Eur J Med Chem202642176653PubTator, text miningPubMed
Phase I Study of Rogocekib in Patients with Advanced, Relapsed, or Refractory Malignant Solid Tumors.Clin Cancer Res202642148878PubTator, text miningPubMed
Phosphoproteomic and kinase networks reveal partial EMT and stress-adaptive growth programs in pediatric Peutz-Jeghers polyps.Pediatr Res202642082734PubTator, text miningPubMed

1 to 10 of 1,704

See all 1,704 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1195

GET https://conductscience.org/api/genes/v1/1195/patents?page=2