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Gene · 1200

TPP1: tripeptidyl peptidase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TPP1: tripeptidyl peptidase 1. Genes, record 1200. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1200

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Gene

Symbol
TPP1
HGNC
Name
tripeptidyl peptidase 1
HGNC
NCBI Gene ID
1200
NCBI Gene
HGNC ID
HGNC:2073
HGNC
Ensembl
ENSG00000166340
NCBI Gene
Aliases
CLN2, GIG1, LPIC, SCAR7, TPP-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14773Tripeptidyl-peptidase 15632Ensembl, GeneID, HGNC

Source UniProt

Patents109

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21302O14773Espacenet
JP 2026021331 A2026-02-108O14773Espacenet
EP 4667578 A22025-12-24274O14773Espacenet
JP 2025172069 A2025-11-20487O14773Espacenet
EP 4650780 A22025-11-193943O14773Espacenet
EP 4641201 A22025-10-293513O14773Espacenet
WO 2025221877 A12025-10-231O14773Espacenet
JP 2025147176 A2025-10-0613696O14773Espacenet
US 12428653 B22025-09-301O14773Espacenet
JP 2025131621 A2025-09-09274O14773Espacenet

1 to 10 of 109

See all 109 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,543

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTPP1 papersNewest fiscal year
R01AG016642Mechanism of the telomeric proliferation limit202025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant122025
P30CA010815Consolidated Basic Cancer Research Program112025
R35CA210036Genome instability in cancer: telomeres and DNA repair92025
P30CA016672Cancer Center Support Grant82025
R01CA207342Roles of Telomeric Oxidative DNA Lesions in Telomere Length Regulation72025
T32AG000114Career Training in the Biology of Aging72025
P30CA008748Cancer Center Support Grant62025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202862025
R01DK067859Development of Assays for Newborn Screening and for Post-Screening Evaluation of Disease Severity62025

1 to 10 of 1,543Source NIH's project files

See all 1,543 nih grants

Papers2,632

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Fission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination.PLoS Genet202642709834PubTator, text miningPubMed
Phenotypic and Genetic Characterization of 64 Egyptian Children With Neuronal Ceroid Lipofuscinosis.Pediatr Neurol202642551284PubTator, text miningPubMed
Fission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination.bioRxiv202642539071PubTator, text miningPubMed
Expanding the genotypic landscape of the neuronal ceroid lipofuscinoses: clinical and molecular findings from a tertiary-care center in Argentina.Seizure202642413193PubTator, text miningPubMed
Identification and analysis of endoplasmic reticulum stress-related genes in neuroblastoma and construction of a prognostic gene signature.Transl Cancer Res202642180899PubTator, text miningPubMed
PPARα and RXRα in the regulation of neuronal ceroid lipofuscinosis genes: implications for Batten disease therapy.NeuroImmune Pharm Ther202642146023PubTator, text miningPubMed
Lysosomal storage, mitochondrial pathology, and autophagy in knockout of tripeptidyl peptidase 1 in human neuroblastoma cells in vitro.Mol Genet Metab202642102651PubTator, text miningPubMed
[Clinical features of 13 children with neuronal ceroid lipofuscinosis type 2].Zhonghua Yi Xue Za Zhi202641986128PubTator, text miningPubMed
Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure.Cardiovasc Res202641942104PubTator, text miningPubMed
Single-Cell and Multi-Omics-Based Characterization of Gastric Cancer Identifies TPP1 as a Potential Target for Gastric Cancer Progression and Treatment.Oncol Res202641930144PubTator, text miningPubMed

1 to 10 of 2,632

See all 2,632 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1200

GET https://conductscience.org/api/genes/v1/1200/patents?page=2