Gene · 1200
TPP1: tripeptidyl peptidase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TPP1: tripeptidyl peptidase 1. Genes, record 1200. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1200
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14773 | Tripeptidyl-peptidase 1 | 563 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents109
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 302 | O14773 | Espacenet |
| JP 2026021331 A | 2026-02-10 | 8 | O14773 | Espacenet |
| EP 4667578 A2 | 2025-12-24 | 274 | O14773 | Espacenet |
| JP 2025172069 A | 2025-11-20 | 487 | O14773 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3943 | O14773 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3513 | O14773 | Espacenet |
| WO 2025221877 A1 | 2025-10-23 | 1 | O14773 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 13696 | O14773 | Espacenet |
| US 12428653 B2 | 2025-09-30 | 1 | O14773 | Espacenet |
| JP 2025131621 A | 2025-09-09 | 274 | O14773 | Espacenet |
1 to 10 of 109
See all 109 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,543
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TPP1 papers | Newest fiscal year |
|---|---|---|---|
| R01AG016642 | Mechanism of the telomeric proliferation limit | 20 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 12 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 11 | 2025 |
| R35CA210036 | Genome instability in cancer: telomeres and DNA repair | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| R01CA207342 | Roles of Telomeric Oxidative DNA Lesions in Telomere Length Regulation | 7 | 2025 |
| T32AG000114 | Career Training in the Biology of Aging | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 6 | 2025 |
| R01DK067859 | Development of Assays for Newborn Screening and for Post-Screening Evaluation of Disease Severity | 6 | 2025 |
1 to 10 of 1,543Source NIH's project files
See all 1,543 nih grantsPapers2,632
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Fission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination. | PLoS Genet | 2026 | 42709834 | PubTator, text mining | PubMed |
| Phenotypic and Genetic Characterization of 64 Egyptian Children With Neuronal Ceroid Lipofuscinosis. | Pediatr Neurol | 2026 | 42551284 | PubTator, text mining | PubMed |
| Fission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination. | bioRxiv | 2026 | 42539071 | PubTator, text mining | PubMed |
| Expanding the genotypic landscape of the neuronal ceroid lipofuscinoses: clinical and molecular findings from a tertiary-care center in Argentina. | Seizure | 2026 | 42413193 | PubTator, text mining | PubMed |
| Identification and analysis of endoplasmic reticulum stress-related genes in neuroblastoma and construction of a prognostic gene signature. | Transl Cancer Res | 2026 | 42180899 | PubTator, text mining | PubMed |
| PPARα and RXRα in the regulation of neuronal ceroid lipofuscinosis genes: implications for Batten disease therapy. | NeuroImmune Pharm Ther | 2026 | 42146023 | PubTator, text mining | PubMed |
| Lysosomal storage, mitochondrial pathology, and autophagy in knockout of tripeptidyl peptidase 1 in human neuroblastoma cells in vitro. | Mol Genet Metab | 2026 | 42102651 | PubTator, text mining | PubMed |
| [Clinical features of 13 children with neuronal ceroid lipofuscinosis type 2]. | Zhonghua Yi Xue Za Zhi | 2026 | 41986128 | PubTator, text mining | PubMed |
| Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure. | Cardiovasc Res | 2026 | 41942104 | PubTator, text mining | PubMed |
| Single-Cell and Multi-Omics-Based Characterization of Gastric Cancer Identifies TPP1 as a Potential Target for Gastric Cancer Progression and Treatment. | Oncol Res | 2026 | 41930144 | PubTator, text mining | PubMed |
1 to 10 of 2,632
See all 2,632 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1200
GET https://conductscience.org/api/genes/v1/1200/patents?page=2