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LRRK2: leucine rich repeat kinase 2

1 protein, 38 patents, 0 drugs, 0 trials, 3,741 NIH grants and 9,466 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolLRRK2HGNC
Nameleucine rich repeat kinase 2HGNC
NCBI Gene ID120892NCBI Gene
HGNC IDHGNC:18618HGNC
EnsemblENSG00000188906NCBI Gene
AliasesAURA17, DARDARIN, DKFZp434H2111, FLJ45829, PARK8, RIPK7, ROCO2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q5S007Leucine-rich repeat serine/threonine-protein kinase 22,52744Ensembl, GeneID, HGNCUniProt

Patents 38

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4770680 A12026-07-0813Q5S007Espacenet
JP 2026518827 A2026-06-1018Q5S007Espacenet
EP 4716542 A12026-04-0124Q5S007Espacenet
US 12558356 B22026-02-244Q5S007Espacenet
EP 4689118 A12026-02-1118Q5S007Espacenet
JP 2026004568 A2026-01-1451390Q5S007Espacenet
EP 4640849 A22025-10-29506Q5S007Espacenet
EP 4641201 A22025-10-293481Q5S007Espacenet
JP 2025519096 A2025-06-24506Q5S007Espacenet
JP 2025517969 A2025-06-123481Q5S007Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3741

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01NS064934Mechanisms of LRRK2 Mediated Neurotoxicity542,025NIH's project files
ZIAAG000948Leucine rich repeat kinase 2 and dominantly inherited Parkinson disease452,025NIH's project files
ZIAAG000937GTPase function of Leucine rich repeat kinase 2312,025NIH's project files
ZIANS003154Genetic characterization of atypical parkinsonism282,025NIH's project files
ZIAAG000944Striatonigral Microcircuits in Motor Control and Parkinson's Disease192,025NIH's project files
R01ES010563Mechanisms of Manganese Neurotoxicity182,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)182,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital152,025NIH's project files
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations132,025NIH's project files
ZIAAG000928Function and Regulation of ALDH1A1-positive Nigrostriatal Dopaminergic Neurons in Motor Performance and Parkinson's disease122,025NIH's project files

Papers 9466

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825921PubTator, text miningPubMed
42818643PubTator, text miningPubMed
42815215PubTator, text miningPubMed
42811365PubTator, text miningPubMed
42806694PubTator, text miningPubMed
42803978PubTator, text miningPubMed
42801451PubTator, text miningPubMed
42786195PubTator, text miningPubMed
42783617PubTator, text miningPubMed
42774389PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license