ConductScience.org, home

Gene · 1213

CLTC: clathrin heavy chain

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. CLTC: clathrin heavy chain. Genes, record 1213. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1213

On this page

Gene

Symbol
CLTC
HGNC
Name
clathrin heavy chain
HGNC
NCBI Gene ID
1213
NCBI Gene
HGNC ID
HGNC:2092
HGNC
Ensembl
ENSG00000141367
NCBI Gene
Aliases
CHC, CHC17, CLH-17, CLTCL2, Hc, MRD56
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q00610Clathrin heavy chain 11,67510Ensembl, GeneID, HGNC

Source UniProt

Patents80

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026094314 A2026-06-0961Q00610Espacenet
JP 2026021360 A2026-02-10152Q00610Espacenet
JP 2026004568 A2026-01-1441629Q00610Espacenet
EP 4650780 A22025-11-192688Q00610Espacenet
EP 4641201 A22025-10-292269Q00610Espacenet
JP 2025517969 A2025-06-122269Q00610Espacenet
JP 2025517970 A2025-06-122688Q00610Espacenet
JP 2025041709 A2025-03-2679Q00610Espacenet
US 12239743 B22025-03-041Q00610Espacenet
US 12239743 B22025-03-046Q00610Espacenet

1 to 10 of 80

See all 80 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,119

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCLTC papersNewest fiscal year
P30CA008748Cancer Center Support Grant252025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis152025
P30CA016672Cancer Center Support Grant112025
ZIAHD001607Protein Trafficking In The Endosomal-Lysosomal System102025
R01DA014204Regulation of Dopamine Transporter by Trafficking92025
P30CA069533OHSU Knight Cancer Institute62025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center62025
ZIAHL006098Architecture and control of exocytosis and endocytosis in excitable cells62025
P30CA016086Cancer Center Support Grant52025
P30CA021765Cancer Center Support Grant (CCSG)52025

1 to 10 of 2,119Source NIH's project files

See all 2,119 nih grants

Papers3,108

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nuclear LC3 Interactome Profiling Identifies Clathrin Heavy Chain as a Mediator of Nuclear LC3 Translocation in Trabecular Meshwork Cells.bioRxiv202642818117PubTator, text miningPubMed
Cognitive Performance Under AI Advice: Development and Initial Validation of a CHC-Informed Assessment for Organizational Decision-Making.J Intell202642783583PubTator, text miningPubMed
Divergent microtubule-organizing center strategies in mammalian gametogenesis.Trends Open202642761981PubTator, text miningPubMed
Exploratory Small RNA Sequencing in Localized Versus Locally Advanced Prostate Cancer: Putative Roles of CLTC and CDK6 as Downstream Targets of Differentially Expressed MicroRNAs.Pharmaceuticals (Basel)202642653639PubTator, text miningPubMed
Ocular Nystagmus as the Initial Presenting Feature in a Patient with Complete CLTC Deletion: Expanding the Genotype-Phenotype Spectrum of CLTC-Related Disorder.Genes (Basel)202642650121PubTator, text miningPubMed
The absorption and endocytosis mechanism of flaxseed cyclic peptide CLQ is mediated by its binding to clathrin.Food Res Int202642632707PubTator, text miningPubMed
Annexin A2 facilitates Japanese encephalitis virus replication by regulating endocytosis and intracellular transport in PK15 cells.Front Microbiol202642630443PubTator, text miningPubMed
COPI Coatomer Regulates Several Steps of HDL Metabolism.Arterioscler Thromb Vasc Biol202642592650PubTator, text miningPubMed
Primary Renal Perivascular Epithelioid Cell Tumor with CLTC::TFE3 Gene Fusion: A Rare Gene Fusion and Masquerading as Renal Cell Carcinoma.Int J Surg Pathol202642523124PubTator, text miningPubMed
Genomic regions exhibiting divergent DNA methylation patterns co-vary with loci associated with sexual signalling traits in a stick insect.Philos Trans R Soc Lond B Biol Sci202642489664PubTator, text miningPubMed

1 to 10 of 3,108

See all 3,108 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1213

GET https://conductscience.org/api/genes/v1/1213/patents?page=2