Gene · 1215
CMA1: chymase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CMA1: chymase 1. Genes, record 1215. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1215
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P23946 | Chymase | 247 | 42 | Ensembl, GeneID, HGNC |
Source UniProt
Patents66
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 41569 | P23946 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1308 | P23946 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3088 | P23946 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5913 | P23946 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5913 | P23946 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1308 | P23946 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 3088 | P23946 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 3088 | P23946 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 3095 | P23946 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 17173 | P23946 | Espacenet |
1 to 10 of 66
See all 66 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| FULACIMSTAT | CHEMBL4297596 | Chymase inhibitor | INHIBITOR |
Source ChEMBL
Trials2
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03412006 | FULACIMSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT02976467 | FULACIMSTAT | PHASE2 | ClinicalTrials.gov |
NIH grants1,588
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CMA1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 9 | 2025 |
| ZIAAI000249 | The Pathogenesis, Diagnosis, and Treatment of Systemic Mast Cell Disorders | 9 | 2025 |
| R01HL076246 | Chemokines in healing myocardial infarction | 8 | 2025 |
| R01HL085440 | Resolution of inflammation in healing myocardial infarcts | 8 | 2025 |
| U19AI104209 | Integrated Genomic and Functional Studies of Immunotherapy for Multi-Food Allergy | 8 | 2025 |
| T32AI007306 | Immunologic Basis of Resistance and Hypersensitivity | 6 | 2025 |
| U19AI070235 | Epithelial Genes in Allergic Inflammation | 6 | 2025 |
| R01AI136041 | Eicosanoid Networks in Aspirin Hypersensitivity | 5 | 2025 |
| U19AI095219 | Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease | 5 | 2025 |
| ZIAAG000240 | Progression of Arterial Aging: the Local MCP-1/MMP-2/TGF-beta 1 Signaling Loop | 5 | 2025 |
1 to 10 of 1,588Source NIH's project files
See all 1,588 nih grantsPapers3,945
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Statement of Retraction: Aedes albopictus salivary proteins adenosine deaminase and 34k2 interact with human mast cell specific proteases tryptase and chymase. | Bioengineered | 2026 | 42821800 | PubTator, text mining | PubMed |
| Evaluating the Impact of Prior Sponge and Lavage Sampling on Gene Expression of Nasal CMA1 and TSLP Collected With Brush. | Clin Exp Allergy | 2026 | 42805255 | PubTator, text mining | PubMed |
| Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer. | J Immunother Cancer | 2026 | 42686373 | PubTator, text mining | PubMed |
| Mechanisms of Obesity-Related Kidney Disease: From Adipose Depot Biology to the Chymase-Aldosterone and Ghrelin-Leptin Axes. | Biomolecules | 2026 | 42650821 | PubTator, text mining | PubMed |
| Localisation of immune cell populations during human fetal testicular development. | Reprod Fertil | 2026 | 42478769 | PubTator, text mining | PubMed |
| Mast cells: "central regulatory hub" of neuro-endocrine-immune dysregulation in vitiligo. | Front Immunol | 2026 | 42433348 | PubTator, text mining | PubMed |
| Cardiac remodelling and dysfunction in cancer patients receiving cardiotoxic therapies: proteomic and metabolomic profiling. | Eur Heart J | 2026 | 42366805 | PubTator, text mining | PubMed |
| Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches. | Pharmacol Rev | 2026 | 42361439 | PubTator, text mining | PubMed |
| Mast Cells and Cardiovascular Disorders. | Curr Vasc Pharmacol | 2026 | 42316564 | PubTator, text mining | PubMed |
| Engagement of chymase-positive mast cells in myocardial damage associated with COVID-19. | Front Cardiovasc Med | 2026 | 42181638 | PubTator, text mining | PubMed |
1 to 10 of 3,945
See all 3,945 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1215
GET https://conductscience.org/api/genes/v1/1215/patents?page=2