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Gene · 1215

CMA1: chymase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CMA1: chymase 1. Genes, record 1215. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1215

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Gene

Symbol
CMA1
HGNC
Name
chymase 1
HGNC
NCBI Gene ID
1215
NCBI Gene
HGNC ID
HGNC:2097
HGNC
Ensembl
ENSG00000092009
NCBI Gene
Aliases
CYH, MCT1, chymase
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23946Chymase24742Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441569P23946Espacenet
EP 4650780 A22025-11-191308P23946Espacenet
JP 2025147176 A2025-10-063088P23946Espacenet
JP 2025529142 A2025-09-045913P23946Espacenet
US 12371689 B22025-07-295913P23946Espacenet
JP 2025517970 A2025-06-121308P23946Espacenet
JP 2025028160 A2025-02-283088P23946Espacenet
KR 1020250010750 A2025-01-213088P23946Espacenet
JP 2024109657 A2024-08-143095P23946Espacenet
US 11446398 B22022-09-2017173P23946Espacenet

1 to 10 of 66

See all 66 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
FULACIMSTATCHEMBL4297596Chymase inhibitorINHIBITOR

Source ChEMBL

Trials2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03412006FULACIMSTATPHASE2ClinicalTrials.gov
NCT02976467FULACIMSTATPHASE2ClinicalTrials.gov

NIH grants1,588

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCMA1 papersNewest fiscal year
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease92025
ZIAAI000249The Pathogenesis, Diagnosis, and Treatment of Systemic Mast Cell Disorders92025
R01HL076246Chemokines in healing myocardial infarction82025
R01HL085440Resolution of inflammation in healing myocardial infarcts82025
U19AI104209Integrated Genomic and Functional Studies of Immunotherapy for Multi-Food Allergy82025
T32AI007306Immunologic Basis of Resistance and Hypersensitivity62025
U19AI070235Epithelial Genes in Allergic Inflammation62025
R01AI136041Eicosanoid Networks in Aspirin Hypersensitivity52025
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease52025
ZIAAG000240Progression of Arterial Aging: the Local MCP-1/MMP-2/TGF-beta 1 Signaling Loop52025

1 to 10 of 1,588Source NIH's project files

See all 1,588 nih grants

Papers3,945

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of Retraction: Aedes albopictus salivary proteins adenosine deaminase and 34k2 interact with human mast cell specific proteases tryptase and chymase.Bioengineered202642821800PubTator, text miningPubMed
Evaluating the Impact of Prior Sponge and Lavage Sampling on Gene Expression of Nasal CMA1 and TSLP Collected With Brush.Clin Exp Allergy202642805255PubTator, text miningPubMed
Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer.J Immunother Cancer202642686373PubTator, text miningPubMed
Mechanisms of Obesity-Related Kidney Disease: From Adipose Depot Biology to the Chymase-Aldosterone and Ghrelin-Leptin Axes.Biomolecules202642650821PubTator, text miningPubMed
Localisation of immune cell populations during human fetal testicular development.Reprod Fertil202642478769PubTator, text miningPubMed
Mast cells: "central regulatory hub" of neuro-endocrine-immune dysregulation in vitiligo.Front Immunol202642433348PubTator, text miningPubMed
Cardiac remodelling and dysfunction in cancer patients receiving cardiotoxic therapies: proteomic and metabolomic profiling.Eur Heart J202642366805PubTator, text miningPubMed
Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches.Pharmacol Rev202642361439PubTator, text miningPubMed
Mast Cells and Cardiovascular Disorders.Curr Vasc Pharmacol202642316564PubTator, text miningPubMed
Engagement of chymase-positive mast cells in myocardial damage associated with COVID-19.Front Cardiovasc Med202642181638PubTator, text miningPubMed

1 to 10 of 3,945

See all 3,945 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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