Gene · 122706
PSMB11: proteasome subunit beta 11
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PSMB11: proteasome subunit beta 11. Genes, record 122706. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/122706
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| A5LHX3 | Proteasome subunit beta type-11 | 300 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents6
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59530 | A5LHX3 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 67686 | A5LHX3 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 170657 | A5LHX3 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 239965 | A5LHX3 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 239965 | A5LHX3 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 239965 | A5LHX3 | Espacenet |
Drugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| BORTEZOMIB | CHEMBL325041 | 26S proteasome inhibitor | INHIBITOR | ChEMBL |
| BORTEZOMIB D-MANNITOL | CHEMBL5315122 | 26S proteasome inhibitor | INHIBITOR | ChEMBL |
| CARFILZOMIB | CHEMBL451887 | 26S proteasome inhibitor | INHIBITOR | ChEMBL |
| IXAZOMIB | CHEMBL2141296 | 26S proteasome inhibitor | INHIBITOR | ChEMBL |
| IXAZOMIB CITRATE | CHEMBL3545432 | 26S proteasome inhibitor | INHIBITOR | ChEMBL |
| MARIZOMIB | CHEMBL371405 | 20S proteasome inhibitor | INHIBITOR | ChEMBL |
| OPROZOMIB | CHEMBL2103884 | 26S proteasome inhibitor | INHIBITOR | ChEMBL |
Trials1,241
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07605416 | CARFILZOMIB | PHASE2 | ClinicalTrials.gov | |
| NCT07601100 | BORTEZOMIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07600151 | BORTEZOMIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07513129 | BORTEZOMIB | PHASE1 | ClinicalTrials.gov | |
| NCT07479979 | CARFILZOMIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07464210 | BORTEZOMIB | PHASE2 | ClinicalTrials.gov | |
| NCT07463807 | CARFILZOMIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07428369 | BORTEZOMIB | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07391657 | BORTEZOMIB | PHASE3 | ClinicalTrials.gov | |
| NCT07391657 | CARFILZOMIB | PHASE3 | ClinicalTrials.gov |
1 to 10 of 1,241
See all 1,241 trialsNIH grants132
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PSMB11 papers | Newest fiscal year |
|---|---|---|---|
| ZIABC011806 | Thymus biology | 3 | 2025 |
| ZIABC009273 | T Cell Differentiation and Repertoire Selection | 2 | 2025 |
| ZIABC011112 | Development and function of regulatory T cells | 2 | 2025 |
| P30AR070155 | RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGY | 1 | 2025 |
| P30CA077598 | Cancer Center Support Grant | 1 | 2025 |
| P30DK116073 | University of Colorado Anschutz Medical Campus DRC | 1 | 2025 |
| P30ES017885 | Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) | 1 | 2025 |
| P50AA022537 | Cross-species investigation of gene networks for ethanol-related behaviors | 1 | 2025 |
| R01AI038903 | T Cell Homeostasis | 1 | 2025 |
| R01AI114495 | Role of Tspan5 in MHC I antigen presentation and cancer immune evasion | 1 | 2025 |
1 to 10 of 132Source NIH's project files
See all 132 nih grantsPapers172
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Thymic APC Networks Orchestrate T-Cell Selection: Mechanisms and Therapeutic Opportunities in Immune Disorders. | Immunology | 2026 | 42339513 | PubTator, text mining | PubMed |
| Thymic cortical epithelial Psmb11-encoded β5t in mouse and human. | Int Immunol | 2026 | 42261593 | PubTator, text mining | PubMed |
| Thymic cyst: A clinicopathological, immunohistochemical, and molecular study of 36 cases focusing on squamous- and ciliated-type epithelium. | Hum Pathol | 2026 | 41850630 | PubTator, text mining | PubMed |
| Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies. | Front Cell Neurosci | 2026 | 41788195 | PubTator, text mining | PubMed |
| An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification. | Nat Commun | 2025 | 40855082 | PubTator, text mining | PubMed |
| Consensus prediction of cell type labels in single-cell data with popV. | Nat Genet | 2024 | 39567746 | PubTator, text mining | PubMed |
| Generation and repair of thymic epithelial cells. | J Exp Med | 2024 | 38980292 | PubTator, text mining | PubMed |
| Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases. | Biology (Basel) | 2023 | 37759569 | PubTator, text mining | PubMed |
| Targeted Protein Degradation: Principles and Applications of the Proteasome. | Cells | 2023 | 37508510 | PubTator, text mining | PubMed |
| Cytogenomic Investigation of Syndromic Brazilian Patients with Differences of Sexual Development. | Diagnostics (Basel) | 2023 | 37443631 | PubTator, text mining | PubMed |
1 to 10 of 172
See all 172 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/122706
GET https://conductscience.org/api/genes/v1/122706/trials?page=2