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Gene · 122706

PSMB11: proteasome subunit beta 11

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMB11: proteasome subunit beta 11. Genes, record 122706. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/122706

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Gene

Symbol
PSMB11
HGNC
Name
proteasome subunit beta 11
HGNC
NCBI Gene ID
122706
NCBI Gene
HGNC ID
HGNC:31963
HGNC
Ensembl
ENSG00000222028
NCBI Gene
Aliases
BETA5T, beta5t
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
A5LHX3Proteasome subunit beta type-113000Ensembl, GeneID, HGNC

Source UniProt

Patents6

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459530A5LHX3Espacenet
US 11446398 B22022-09-2067686A5LHX3Espacenet
JP 2022524081 A2022-04-27170657A5LHX3Espacenet
JP 2019054813 A2019-04-11239965A5LHX3Espacenet
JP 2017121241 A2017-07-13239965A5LHX3Espacenet
JP 2015516143 A2015-06-08239965A5LHX3Espacenet

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants132

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMB11 papersNewest fiscal year
ZIABC011806Thymus biology32025
ZIABC009273T Cell Differentiation and Repertoire Selection22025
ZIABC011112Development and function of regulatory T cells22025
P30AR070155RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGY12025
P30CA077598Cancer Center Support Grant12025
P30DK116073University of Colorado Anschutz Medical Campus DRC12025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)12025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors12025
R01AI038903T Cell Homeostasis12025
R01AI114495Role of Tspan5 in MHC I antigen presentation and cancer immune evasion12025

1 to 10 of 132Source NIH's project files

See all 132 nih grants

Papers172

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Thymic APC Networks Orchestrate T-Cell Selection: Mechanisms and Therapeutic Opportunities in Immune Disorders.Immunology202642339513PubTator, text miningPubMed
Thymic cortical epithelial Psmb11-encoded β5t in mouse and human.Int Immunol202642261593PubTator, text miningPubMed
Thymic cyst: A clinicopathological, immunohistochemical, and molecular study of 36 cases focusing on squamous- and ciliated-type epithelium.Hum Pathol202641850630PubTator, text miningPubMed
Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.Front Cell Neurosci202641788195PubTator, text miningPubMed
An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification.Nat Commun202540855082PubTator, text miningPubMed
Consensus prediction of cell type labels in single-cell data with popV.Nat Genet202439567746PubTator, text miningPubMed
Generation and repair of thymic epithelial cells.J Exp Med202438980292PubTator, text miningPubMed
Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases.Biology (Basel)202337759569PubTator, text miningPubMed
Targeted Protein Degradation: Principles and Applications of the Proteasome.Cells202337508510PubTator, text miningPubMed
Cytogenomic Investigation of Syndromic Brazilian Patients with Differences of Sexual Development.Diagnostics (Basel)202337443631PubTator, text miningPubMed

1 to 10 of 172

See all 172 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/122706

GET https://conductscience.org/api/genes/v1/122706/trials?page=2