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CCR5: C-C motif chemokine receptor 5

1 protein, 256 patents, 14 drugs, 114 trials, 13,580 NIH grants and 27,422 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCCR5HGNC
NameC-C motif chemokine receptor 5HGNC
NCBI Gene ID1234NCBI Gene
HGNC IDHGNC:1606HGNC
EnsemblENSG00000160791NCBI Gene
AliasesCC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P51681C-C chemokine receptor type 535226Ensembl, GeneID, HGNCUniProt

Patents 256

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026170016 A12026-08-1312P51681Espacenet
JP 2026062654 A2026-04-1026P51681Espacenet
EP 4705273 A22026-03-11448P51681Espacenet
JP 2026004568 A2026-01-1441052P51681Espacenet
JP 2026004568 A2026-01-1441053P51681Espacenet
JP 2026004568 A2026-01-1441055P51681Espacenet
EP 4667578 A22025-12-24223P51681Espacenet
WO 2025259871 A12025-12-1822P51681Espacenet
EP 4641201 A22025-10-293080P51681Espacenet
JP 2025535503 A2025-10-2448P51681Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APLAVIROCCHEMBL1255794C-C chemokine receptor type 5 antagonistANTAGONISTChEMBL
APLAVIROC HYDROCHLORIDECHEMBL1668019C-C chemokine receptor type 5 antagonistANTAGONISTChEMBL
AZD5672CHEMBL1951914C-C chemokine receptor type 5 antagonistANTAGONISTChEMBL
BMS-813160CHEMBL4594419C-C chemokine receptor type 5 antagonistANTAGONISTChEMBL
CCR5MAB004CHEMBL2109341C-C chemokine receptor type 5 inhibitorINHIBITORChEMBL
CENICRIVIROCCHEMBL2110727C-C chemokine receptor type 5 antagonistANTAGONISTChEMBL
HGS-1025CHEMBL2109342C-C chemokine receptor type 5 inhibitorINHIBITORChEMBL
INCB-9471CHEMBL1688243C-C chemokine receptor type 5 antagonistANTAGONISTChEMBL
LERONLIMABCHEMBL2109343C-C chemokine receptor type 5 antagonistANTAGONISTChEMBL
MARAVIROCCHEMBL256907C-C chemokine receptor type 5 antagonistANTAGONISTChEMBL

Trials 114

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07553338LERONLIMABPHASE2ClinicalTrials.gov
NCT07536815LERONLIMABClinicalTrials.gov
NCT07080567MARAVIROCPHASE2ClinicalTrials.gov
NCT06974084MARAVIROCPHASE2/PHASE3ClinicalTrials.gov
NCT06805656MARAVIROCPHASE2ClinicalTrials.gov
NCT06699836LERONLIMABPHASE2ClinicalTrials.gov
NCT05730673LERONLIMABPHASE2ClinicalTrials.gov
NCT05470491MARAVIROCPHASE1/PHASE2ClinicalTrials.gov
NCT05271370LERONLIMABPHASE2/PHASE32025-10-30ClinicalTrials.gov
NCT04966429MARAVIROCPHASE2ClinicalTrials.gov

NIH grants 13580

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30AI050410The University of North Carolina Center for AIDS Research1332,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research1292,025NIH's project files
P30AI060354Harvard University Center for AIDS Research1282,025NIH's project files
P30AI027757University of Washington/Fred Hutch Center for AIDS Research982,025NIH's project files
P30AI050409Center for AIDS Research at Emory University962,025NIH's project files
P51OD011132Emory National Primate Research Center942,025NIH's project files
P51OD011104Tulane National Primate Research Center902,025NIH's project files
P30AI045008Penn Center for AIDS Research882,025NIH's project files
P30AI036214San Diego Center for AIDS Research (SD CFAR)852,025NIH's project files
P30AI027767UAB Center for AIDS Research (CFAR)762,025NIH's project files

Papers 27422

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823508PubTator, text miningPubMed
42822323PubTator, text miningPubMed
42812567PubTator, text miningPubMed
42797803PubTator, text miningPubMed
42797766PubTator, text miningPubMed
42794723PubTator, text miningPubMed
42789690PubTator, text miningPubMed
42781660PubTator, text miningPubMed
42773463PubTator, text miningPubMed
42769001PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license