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Gene · 1237

CCR8: C-C motif chemokine receptor 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CCR8: C-C motif chemokine receptor 8. Genes, record 1237. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1237

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Gene

Symbol
CCR8
HGNC
Name
C-C motif chemokine receptor 8
HGNC
NCBI Gene ID
1237
NCBI Gene
HGNC ID
HGNC:1609
HGNC
Ensembl
ENSG00000179934
NCBI Gene
Aliases
CC-CKR-8, CCR-8, CDw198, CKR-L1, CKRL1, CMKBR8, CMKBRL2, CY6, GPR-CY6, GPRCY6, TER1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51685C-C chemokine receptor type 83556Ensembl, GeneID, HGNC

Source UniProt

Patents167

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026170016 A12026-08-131P51685Espacenet
EP 4778939 A12026-07-2281P51685Espacenet
US 12655223 B22026-06-162P51685Espacenet
JP 2026515899 A2026-05-1937P51685Espacenet
WO 2026100725 A2026-05-151P51685Espacenet
EP 4722248 A12026-04-0883P51685Espacenet
EP 4705346 A22026-03-1137P51685Espacenet
JP 2026507758 A2026-03-0612P51685Espacenet
WO 2026019990 A12026-01-2222P51685Espacenet
JP 2026004568 A2026-01-1441060P51685Espacenet

1 to 10 of 167

See all 167 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,226

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCCR8 papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital92025
P30AR069625Human Skin Disease Resource-based Center42025
ZIAAI000615Molecular Analysis Of Leukocyte Activation By Chemoattractants42025
P01CA019014Viral Oncogenesis, Latency, and Replication32025
P30CA016672Cancer Center Support Grant32025
P30CA086862Cancer Center Support Grant32025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease32025
R01AI123349Cellular mechanisms by which exhausted T cell responses are restored32025
T32AI007290Molecular and Cellular Immunobiology32025

1 to 10 of 1,226Source NIH's project files

See all 1,226 nih grants

Papers2,300

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Immunometabolic Profiling of T Cells and Innate Lymphoid Cells Uncovers Therapeutic Targets to Enhance Immunotherapy in Head and Neck Cancer.Cancer Immunol Res202642804348PubTator, text miningPubMed
Spatial Treg niches and the therapeutic reprogramming of tumour tolerance in cancer.Front Cell Dev Biol202642769030PubTator, text miningPubMed
Molecular heterogeneity and clonal origin of CCR8+ effector regulatory T cells in human cancer.Nat Commun202642764351PubTator, text miningPubMed
Semi-Mechanistic Modeling of S-531011, a Humanized Anti-CCR8 Monoclonal Antibody, for Prediction of CCR8 Receptor Occupancy in Human Tumor Tissues.CPT Pharmacometrics Syst Pharmacol202642689490PubTator, text miningPubMed
Nonpathogenic SIV Infection in Sooty Mangabeys Is Characterized by a Lack of Activation and Expansion of Monocytes.J Med Primatol202642596509PubTator, text miningPubMed
Tape-strip transcriptomics identify immune signatures in cutaneous T-cell lymphoma distinct from benign inflammatory skin diseases.J Allergy Clin Immunol202642567485PubTator, text miningPubMed
Leukocyte-Rich Platelet-Rich Plasma (L-PRP) Promotes Rejuvenation of Senescent Fibroblasts and Dermal Remodeling via CCL1-CCR8 Signaling and PKM2 Modulation.Int J Mol Sci202642511624PubTator, text miningPubMed
Next-generation precision oncology in microsatellite stable colorectal cancer: integrated targeting beyond RAS and RAF.ESMO Open202642462280PubTator, text miningPubMed
BLIMP-1 and CD39 expression define human effector memory regulatory T cells in blood and recall responses to viruses.Immunol Cell Biol202642448314PubTator, text miningPubMed
Selective Depletion of Tumor-Infiltrating CD4+CCR8+ Tregs by AZ084, a Novel CCR8 Antagonist.Cancer Sci202642437746PubTator, text miningPubMed

1 to 10 of 2,300

See all 2,300 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1237

GET https://conductscience.org/api/genes/v1/1237/patents?page=2