Gene · 1263
PLK3: polo like kinase 3
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. PLK3: polo like kinase 3. Genes, record 1263. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1263
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H4B4 | Serine/threonine-protein kinase PLK3 | 646 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 9070 | Q9H4B4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9344 | Q9H4B4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 9344 | Q9H4B4 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9070 | Q9H4B4 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7746 | Q9H4B4 | Espacenet |
| JP 2024525977 A | 2024-07-12 | 1 | Q9H4B4 | Espacenet |
| US 11892452 B2 | 2024-02-06 | 3 | Q9H4B4 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1373 | Q9H4B4 | Espacenet |
| KR 1020230171856 A | 2023-12-21 | 1 | Q9H4B4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 64477 | Q9H4B4 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants937
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PLK3 papers | Newest fiscal year |
|---|---|---|---|
| ZIABC010681 | Development of inhibitors targeting Plk1 polo-box domain | 13 | 2025 |
| ZIABC006198 | Inhibitors of Tyrosine Kinase-Dependent Signaling as Anti-Cancer Agents | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P20GM109036 | Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
| U19AG055373 | Trans-omics Integration of Multi-omics Studies for Osteoporosis | 5 | 2025 |
| R01AI099222 | Regulation of host innate and adaptive immunity by bacterial type III effectors | 4 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 937Source NIH's project files
See all 937 nih grantsPapers1,568
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Induced ocular higher-order aberrations after PRK vs LASIK for myopia: systematic review and meta-analysis. | J Cataract Refract Surg | 2027 | 42622059 | PubTator, text mining | PubMed |
| Iron-enhanced rTCA cycle drives synergistic enhancement of inorganic carbon fixation and denitrification. | Water Res | 2026 | 42767070 | PubTator, text mining | PubMed |
| Analysis of hypoxia-inducible factors in the deep-sea fish reveals genetic adaptation to hypoxic environments. | Zool Res | 2026 | 42706785 | PubTator, text mining | PubMed |
| Early Visual, Refractive, and Astigmatism Vector Outcomes of StreamLight Trans-PRK for High Astigmatism (≥ 2.00 D). | Rom J Ophthalmol | 2026 | 42572681 | PubTator, text mining | PubMed |
| Cell-cycle-dependent regulation of DNA end resection by PLK1 and PLK3 without CtIP level modulation. | iScience | 2026 | 42436985 | PubTator, text mining | PubMed |
| Inflammatory and Anti-Inflammatory Response of the Ocular Surface After Excimer Laser Treatment. | Biomedicines | 2026 | 42351765 | PubTator, text mining | PubMed |
| Laser vision correction (LASIK, PRK, SMILE) with simultaneous accelerated corneal crosslinking. | Curr Opin Ophthalmol | 2026 | 42348672 | PubTator, text mining | PubMed |
| Structure-Guided Discovery of Selective Polo-Like Kinase 3 Inhibitors. | ACS Med Chem Lett | 2026 | 42305216 | PubTator, text mining | PubMed |
| Ventilation-Associated Differences in Lower Airway Microbial Signatures and Peripheral Blood Transcriptome Among Critically Ill COVID-19 Patients. | Infect Drug Resist | 2026 | 42293984 | PubTator, text mining | PubMed |
| Retreatment using LASIK, PRK, or ICL for myopic regression after corneal laser refractive surgery. | BMC Ophthalmol | 2026 | 42260445 | PubTator, text mining | PubMed |
1 to 10 of 1,568
See all 1,568 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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