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CNR1: cannabinoid receptor 1

1 protein, 113 patents, 13 drugs, 604 trials, 5,238 NIH grants and 11,993 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCNR1HGNC
Namecannabinoid receptor 1HGNC
NCBI Gene ID1268NCBI Gene
HGNC IDHGNC:2159HGNC
EnsemblENSG00000118432NCBI Gene
AliasesCANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNRNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P21554Cannabinoid receptor 147234Ensembl, GeneID, HGNCUniProt

Patents 113

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026076162 A2026-05-111P21554Espacenet
JP 2026004568 A2026-01-1439927P21554Espacenet
JP 2026004568 A2026-01-1439928P21554Espacenet
JP 2026004568 A2026-01-1439929P21554Espacenet
JP 2026004568 A2026-01-1439931P21554Espacenet
JP 2026004568 A2026-01-1439932P21554Espacenet
JP 2026004568 A2026-01-1439934P21554Espacenet
EP 4650780 A22025-11-198632P21554Espacenet
EP 4641201 A22025-10-298800P21554Espacenet
JP 2025163008 A2025-10-281P21554Espacenet

Drugs 13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD2207CHEMBL3545289Cannabinoid CB1 receptor antagonistANTAGONISTChEMBL
CANNABIDIOLCHEMBL190461Cannabinoid CB1 receptor negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
DRINABANTCHEMBL3545166Cannabinoid CB1 receptor antagonistANTAGONISTChEMBL
DRONABINOLCHEMBL465Cannabinoid CB1 receptor agonistAGONISTChEMBL
IBIPINABANTCHEMBL412262Cannabinoid CB1 receptor antagonistANTAGONISTChEMBL
NABILONECHEMBL2218896Cannabinoid CB1 receptor agonistAGONISTChEMBL
NIMACIMABCHEMBL4298095Cannabinoid CB1 receptor negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
NONABINECHEMBL2106841Cannabinoid CB1 receptor agonistAGONISTChEMBL
OTENABANTCHEMBL562668Cannabinoid CB1 receptor antagonistANTAGONISTChEMBL
RIMONABANTCHEMBL111Cannabinoid CB1 receptor antagonistANTAGONISTChEMBL

Trials 604

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07592390CANNABIDIOLPHASE1/PHASE2ClinicalTrials.gov
NCT07592390DRONABINOLPHASE1/PHASE2ClinicalTrials.gov
NCT07570953DRONABINOLPHASE2/PHASE3ClinicalTrials.gov
NCT07570472CANNABIDIOLPHASE2ClinicalTrials.gov
NCT07565974DRONABINOLPHASE2ClinicalTrials.gov
NCT07564245CANNABIDIOLPHASE2ClinicalTrials.gov
NCT07552974CANNABIDIOLPHASE2/PHASE3ClinicalTrials.gov
NCT07498023CANNABIDIOLPHASE1/PHASE2ClinicalTrials.gov
NCT07498023DRONABINOLPHASE1/PHASE2ClinicalTrials.gov
NCT07445568CANNABIDIOLClinicalTrials.gov

NIH grants 5238

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01DA009158Endocannabinoid Active Sites as Therapeutic Targets1202,025NIH's project files
ZIAAA000350Endocannabinoids And Energy Homeostasis342,025NIH's project files
ZIAAA000375Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injury332,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award242,025NIH's project files
ZIAMH002793PET Radiopharmaceutical Sciences232,025NIH's project files
R01DA040460Investigation of Synthetic Cannabinoid Exposures and Pharmacological Consequences222,025NIH's project files
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS202,025NIH's project files
T32DA007027Training in the pharmacology of abused drugs192,025NIH's project files
R01DA008863Regulation Of Opioid Receptor Signaling by Endogenous Peptides162,025NIH's project files
ZIAAA000351Endocannabinoids and the Control Of Behavior and Cardiovascular Function152,025NIH's project files

Papers 11993

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825590PubTator, text miningPubMed
42818206PubTator, text miningPubMed
42808403PubTator, text miningPubMed
42805116PubTator, text miningPubMed
42791631PubTator, text miningPubMed
42777800PubTator, text miningPubMed
42773392PubTator, text miningPubMed
42753683PubTator, text miningPubMed
42753475PubTator, text miningPubMed
42745361PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license