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CNR2: cannabinoid receptor 2

1 protein, 42 patents, 8 drugs, 9 trials, 2,901 NIH grants and 7,015 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCNR2HGNC
Namecannabinoid receptor 2HGNC
NCBI Gene ID1269NCBI Gene
HGNC IDHGNC:2160HGNC
EnsemblENSG00000188822NCBI Gene
AliasesCB-2, CB2, CX5NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P34972Cannabinoid receptor 236010Ensembl, GeneID, HGNCUniProt

Patents 42

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439936P34972Espacenet
JP 2026004568 A2026-01-1439937P34972Espacenet
JP 2025529142 A2025-09-041064P34972Espacenet
US 12371689 B22025-07-291064P34972Espacenet
JP 2025062604 A2025-04-1411515P34972Espacenet
US 12161663 B22024-12-105P34972Espacenet
JP 2023153821 A2023-10-1839P34972Espacenet
US 11446398 B22022-09-2011515P34972Espacenet
US 11407837 B22022-08-0939P34972Espacenet
US 11400116 B22022-08-022486P34972Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
GW842166XCHEMBL225411Cannabinoid CB2 receptor agonistAGONISTChEMBL
LY2828360CHEMBL3139186Cannabinoid CB2 receptor agonistAGONISTChEMBL
NONABINECHEMBL2106841Cannabinoid CB2 receptor agonistAGONISTChEMBL
OLORINABCHEMBL4175981Cannabinoid CB2 receptor agonistAGONISTChEMBL
PRS-211375CHEMBL3234035Cannabinoid CB2 receptor agonistAGONISTChEMBL
S-777469CHEMBL2019090Cannabinoid CB2 receptor agonistAGONISTChEMBL
SAD448CHEMBL2397751Cannabinoid CB2 receptor agonistAGONISTChEMBL
TEDALINABCHEMBL3234681Cannabinoid CB2 receptor agonistAGONISTChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04655599OLORINABPHASE1ClinicalTrials.gov
NCT04043455OLORINABPHASE22022-10-12ClinicalTrials.gov
NCT03155945OLORINABPHASE22021-11-02ClinicalTrials.gov
NCT00703573S-777469PHASE2ClinicalTrials.gov
NCT00697710S-777469PHASE1/PHASE2ClinicalTrials.gov
NCT00503360SAD448PHASE1ClinicalTrials.gov
NCT00479427GW842166XPHASE2ClinicalTrials.gov
NCT00447486GW842166XPHASE2ClinicalTrials.gov
NCT00444769GW842166XPHASE2ClinicalTrials.gov

NIH grants 2901

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01DA009158Endocannabinoid Active Sites as Therapeutic Targets782,025NIH's project files
ZIAAA000375Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injury202,025NIH's project files
R01DA040460Investigation of Synthetic Cannabinoid Exposures and Pharmacological Consequences162,025NIH's project files
P30CA016672Cancer Center Support Grant122,025NIH's project files
T32DA007027Training in the pharmacology of abused drugs112,025NIH's project files
T32DA007237Neurobiology of Addiction Training Program112,025NIH's project files
ZIAAA000350Endocannabinoids And Energy Homeostasis112,025NIH's project files
P30MH062512HIV Neurobehavioral Research Center92,025NIH's project files
P30EY001319Core grant for vision research72,025NIH's project files
T32ES011564UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAM72,025NIH's project files

Papers 7015

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818206PubTator, text miningPubMed
42797451PubTator, text miningPubMed
42783432PubTator, text miningPubMed
42777800PubTator, text miningPubMed
42763829PubTator, text miningPubMed
42745361PubTator, text miningPubMed
42734521PubTator, text miningPubMed
42722230PubTator, text miningPubMed
42658346PubTator, text miningPubMed
42653723PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license