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Gene · 128

ADH5: alcohol dehydrogenase 5 (class III), chi polypeptide

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADH5: alcohol dehydrogenase 5 (class III), chi polypeptide. Genes, record 128. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/128

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Gene

Symbol
ADH5
HGNC
Name
alcohol dehydrogenase 5 (class III), chi polypeptide
HGNC
NCBI Gene ID
128
NCBI Gene
HGNC ID
HGNC:253
HGNC
Ensembl
ENSG00000197894
NCBI Gene
Aliases
ADH-3, ADHX, AMEDS, BMFS7, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P11766Alcohol dehydrogenase class-337410Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436971P11766Espacenet
EP 4650780 A22025-11-193716P11766Espacenet
EP 4641201 A22025-10-293300P11766Espacenet
JP 2025517969 A2025-06-123300P11766Espacenet
JP 2025517970 A2025-06-123716P11766Espacenet
JP 2025062604 A2025-04-143797P11766Espacenet
US 11446398 B22022-09-203797P11766Espacenet
JP 2022524081 A2022-04-27106768P11766Espacenet
US 11078247 B22021-08-03278P11766Espacenet
WO 2020043864 A12020-03-0582P11766Espacenet

1 to 10 of 26

See all 26 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CAVOSONSTATCHEMBL3989910Alcohol dehydrogenase class III inhibitorINHIBITORChEMBL
N6022CHEMBL1738699Alcohol dehydrogenase class III inhibitorINHIBITORChEMBL
NITREFAZOLECHEMBL1909285Alcohol dehydrogenase inhibitorINHIBITORChEMBL

Trials8

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04600778CAVOSONSTATPHASE2ClinicalTrials.gov
NCT04129931CAVOSONSTATPHASE2ClinicalTrials.gov
NCT02724527CAVOSONSTATPHASE2ClinicalTrials.gov
NCT02589236CAVOSONSTATPHASE2ClinicalTrials.gov
NCT02275936CAVOSONSTATPHASE1ClinicalTrials.gov
NCT02227888CAVOSONSTATPHASE1ClinicalTrials.gov
NCT01746784N6022PHASE12014-11-24ClinicalTrials.gov
NCT01316315N6022PHASE1/PHASE22014-03-11ClinicalTrials.gov

NIH grants1,060

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADH5 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).182025
P50AA012870Center for the Translational Neuroscience of Alcoholism92025
P30DK026743UCSF Liver Center52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
P30ES013508Center of Excellence in Environmental Toxicology42025
P42ES004705Toxic substances in the environment42025
R01DA0548697/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact42025
R01ES028096Chemical Probes to Study Formaldehyde Biology42025

1 to 10 of 1,060Source NIH's project files

See all 1,060 nih grants

Papers1,451

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Functional and Compositional Shifts in Lung and Gut Microbiota after One Year of Treatment with Highly Effective CFTR Modulators in Cystic Fibrosis.Arch Bronconeumol202642791132PubTator, text miningPubMed
Immunomodulatory and anti-inflammatory potential of S-nitrosoglutathione (GSNO) in multiple sclerosis: a review of mechanisms and therapeutic perspectives.Front Immunol202642688580PubTator, text miningPubMed
Error-calibrated sensing: ratiometric biosensor for carcinogenic formaldehyde in food safety monitoring.Food Chem202642685422PubTator, text miningPubMed
HPCA1 and CaM3 contribute to peroxisomal H2O2-driven activation of salicylic acid responses.Plant Physiol202642612176PubTator, text miningPubMed
Unraveling the association between triclosan and breast cancer: A multidimensional research strategy integrating machine learning, mendelian randomization, and molecular dynamics simulations.Environ Int202642594736PubTator, text miningPubMed
Human Nasal and Bronchial Epithelium in Cystic Fibrosis: Differences in Expression of Airway pH Regulatory Proteins.Pediatr Pulmonol202642591023PubTator, text miningPubMed
Excess folate elevates formaldehyde genotoxicity in cell lines but not in mice or humans.EMBO Mol Med202642587126PubTator, text miningPubMed
Nuclear SOD1 links ATM-CHK2 signaling to ADH5/GSNOR transcription in SHSY-5Y SOD1G93A cellular models of ALS.Nitric Oxide202642586199PubTator, text miningPubMed
GNPs-pIL-4 reprograms macrophage polarization and activates the OSM/GSNOR/ENG axis to improve angiogenesis in ischemic limbs.Sci Adv202642585315PubTator, text miningPubMed
GSNOR reprograms nitrosylation to drive endothelial-to-mesenchymal transition and fibrotic vascular remodeling.Redox Biol202642579926PubTator, text miningPubMed

1 to 10 of 1,451

See all 1,451 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/128

GET https://conductscience.org/api/genes/v1/128/patents?page=2