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COL2A1: collagen type II alpha 1 chain

1 protein, 100 patents, 2 drugs, 66 trials, 2,248 NIH grants and 6,505 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCOL2A1HGNC
Namecollagen type II alpha 1 chainHGNC
NCBI Gene ID1280NCBI Gene
HGNC IDHGNC:2200HGNC
EnsemblENSG00000139219NCBI Gene
AliasesACG2, ANFH, ANFH1, AOM, COL11A3, EDMMD, LCPD, OSCDP, PLSDT, SEDC, SEDSTN, SEMDSTWK, SMDALG, STL1, VPEDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P02458Collagen alpha-1(II) chain1,48710Ensembl, GeneID, HGNCUniProt

Patents 100

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026190225 A12026-09-1762P02458Espacenet
JP 2026515744 A2026-05-19212P02458Espacenet
US 12560619 B22026-02-24102P02458Espacenet
EP 4694927 A12026-02-1824P02458Espacenet
WO 2025262215 A12025-12-263P02458Espacenet
EP 4667490 A12025-12-243P02458Espacenet
EP 4650780 A22025-11-1910323P02458Espacenet
EP 4641201 A22025-10-2910637P02458Espacenet
JP 2025147176 A2025-10-063285P02458Espacenet
JP 2025529142 A2025-09-045950P02458Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials 66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

NIH grants 2248

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30AR074992RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE142,025NIH's project files
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center122,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
P30AR069619Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)102,025NIH's project files
P30CA016672Cancer Center Support Grant92,025NIH's project files
T32AR060719Skeletal Disorders Training Program92,025NIH's project files
P30AG028716Duke Claude D. Pepper Older Americans Independence Center82,025NIH's project files
P20GM103434West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)72,025NIH's project files
P41EB021911Center for Modular Manufacturing of Structural Tissues72,025NIH's project files
R24HD000836Laboratory of Developmental Biology72,025NIH's project files

Papers 6505

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822803PubTator, text miningPubMed
42820640PubTator, text miningPubMed
42812603PubTator, text miningPubMed
42809989PubTator, text miningPubMed
42806071PubTator, text miningPubMed
42801603PubTator, text miningPubMed
42800420PubTator, text miningPubMed
42792769PubTator, text miningPubMed
42791837PubTator, text miningPubMed
42789005PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license