Gene · 1294
COL7A1: collagen type VII alpha 1 chain
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. COL7A1: collagen type VII alpha 1 chain. Genes, record 1294. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1294
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q02388 | Collagen alpha-1(VII) chain | 2,944 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents147
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 400 | Q02388 | Espacenet |
| EP 4705273 A2 | 2026-03-11 | 490 | Q02388 | Espacenet |
| EP 4705273 A2 | 2026-03-11 | 498 | Q02388 | Espacenet |
| JP 2026042028 A | 2026-03-10 | 20 | Q02388 | Espacenet |
| JP 2026004289 A | 2026-01-14 | 2 | Q02388 | Espacenet |
| JP 2025185268 A | 2025-12-19 | 2 | Q02388 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5963 | Q02388 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 917 | Q02388 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5698 | Q02388 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3347 | Q02388 | Espacenet |
1 to 10 of 147
See all 147 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| BEREMAGENE GEPERPAVEC | CHEMBL4594328 | Collagen alpha-1(VII) chain exogenous gene | EXOGENOUS GENE |
Source ChEMBL
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04917874 | BEREMAGENE GEPERPAVEC | PHASE3 | ClinicalTrials.gov | |
| NCT04491604 | BEREMAGENE GEPERPAVEC | PHASE3 | 2023-02-17 | ClinicalTrials.gov |
| NCT03536143 | BEREMAGENE GEPERPAVEC | PHASE1/PHASE2 | 2023-01-31 | ClinicalTrials.gov |
NIH grants1,032
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | COL7A1 papers | Newest fiscal year |
|---|---|---|---|
| R01AR063070 | Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa | 29 | 2025 |
| P01CA065493 | Off-the-Shelf Immune Effector Cells for Hematological Malignancies | 8 | 2025 |
| R01AR045192 | REGULATORS OF EPIDERMAL GENE EXPRESSION | 7 | 2025 |
| R01EY025794 | ABCB5-positive stem cells for LSCD therapy | 6 | 2025 |
| P30CA077598 | Cancer Center Support Grant | 5 | 2025 |
| R13AR009431 | Montagna Symposium on the Biology of Skin | 5 | 2025 |
| T32AR007465 | Penn Dermatology Research Training Program | 5 | 2025 |
| P30AR069589 | Penn Skin Biology and Diseases Resource-based Center | 4 | 2025 |
| P30EY025585 | NEI Center Core Grant for Vision Research | 4 | 2025 |
| R01AR043799 | Mechanisms of Epidermal Homeostasis and Early Neoplasia | 4 | 2025 |
1 to 10 of 1,032Source NIH's project files
See all 1,032 nih grantsPapers2,575
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Neonatal Skin Blistering and Denudement Caused by Epidermolysis Bullosa. | Cureus | 2026 | 42699182 | PubTator, text mining | PubMed |
| Epidermolysis Bullosa Classification and Current Approach to Diagnosis. | Pediatr Dermatol | 2026 | 42696398 | PubTator, text mining | PubMed |
| Targeting, Mutagenesis, and Functional Testing Strategies for Large Collagens. | Methods Mol Biol | 2026 | 42681148 | PubTator, text mining | PubMed |
| A PepFect14 analog improves non-viral CRISPR delivery in primary human cells to facilitate genome editing and repair. | Bioeng Transl Med | 2026 | 42666741 | PubTator, text mining | PubMed |
| Japanese intractable and rare dermatologic diseases: From the official skin-centered nanbyo core to an illustrative mechanism-based framework. | Intractable Rare Dis Res | 2026 | 42643679 | PubTator, text mining | PubMed |
| A variant of uncertain significance in COL7A1 in Bart syndrome: A case report. | JAAD Case Rep | 2026 | 42603996 | PubTator, text mining | PubMed |
| Molecular basis of collagen triple helix recognition by VWF A-like domain two of collagen VII: Implications for interlaced anchoring fibril formation. | J Biol Chem | 2026 | 42595117 | PubTator, text mining | PubMed |
| Integrative multi-omics analysis identifies SMIM24 as a favorable prognostic biomarker in clear cell renal cell carcinoma. | Funct Integr Genomics | 2026 | 42587209 | PubTator, text mining | PubMed |
Topical gene therapy for severe recessive dystrophic epidermolysis bullosa: clinical outcomes and multidisciplinary management in three patients treated with beremagene geperpavec (B-VEC) in Italy - a case series. | Drugs Context | 2026 | 42578000 | PubTator, text mining | PubMed |
| Gene Therapy for Dystrophic Epidermolysis Bullosa. | Exp Dermatol | 2026 | 42568047 | PubTator, text mining | PubMed |
1 to 10 of 2,575
See all 2,575 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1294
GET https://conductscience.org/api/genes/v1/1294/patents?page=2