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Gene · 1300

COL10A1: collagen type X alpha 1 chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COL10A1: collagen type X alpha 1 chain. Genes, record 1300. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1300

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Gene

Symbol
COL10A1
HGNC
Name
collagen type X alpha 1 chain
HGNC
NCBI Gene ID
1300
NCBI Gene
HGNC ID
HGNC:2185
HGNC
Ensembl
ENSG00000123500
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q03692Collagen alpha-1(X) chain6801Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191085Q03692Espacenet
EP 4640849 A22025-10-29120Q03692Espacenet
EP 4641201 A22025-10-29762Q03692Espacenet
JP 2025147176 A2025-10-063205Q03692Espacenet
JP 2025147176 A2025-10-063206Q03692Espacenet
JP 2025529142 A2025-09-045932Q03692Espacenet
US 12371689 B22025-07-295932Q03692Espacenet
JP 2025519096 A2025-06-24120Q03692Espacenet
JP 2025517969 A2025-06-12762Q03692Espacenet
JP 2025517970 A2025-06-121085Q03692Espacenet

1 to 10 of 60

See all 60 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants950

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOL10A1 papersNewest fiscal year
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center72025
P30AR074992RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE72025
P41EB021911Center for Modular Manufacturing of Structural Tissues62025
U54GM115677Advance Clinical and Translational Research (Advance-CTR)52025
T90DE021982Doctoral and Post-doctoral Training in Craniofacial Biology42025
ZIADE000380The role of stem cells in skeletal health and disease42025
K12EY016335Harvard-Vision Clinical Scientist Development Program32025
P20GM103434West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)32025
P20GM121322Tumor Microenvironment-TME CoBRE32025
P30AR069619Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)32025

1 to 10 of 950Source NIH's project files

See all 950 nih grants

Papers2,140

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Heart failure may promote breast cancer progression through a Col10a1-associated Tgf-β/Smad-EMT pathway.Biol Direct202642806392PubTator, text miningPubMed
In vitro chondrogenic differentiation is improved by the BMP7-derived peptide p[63-82].Peptides202642778025PubTator, text miningPubMed
Analysis of the clinical diagnostic efficacy of the novel serum markers lipase F, gastrokine 2 and the collagen X-type α1 chain in gastric cancer.J Med Biochem202642769816PubTator, text miningPubMed
Oxygen Consumption Rate-Defined Phases Couple Metabolism to Matrix Dynamics in Chondrocyte-Mesenchymal Stromal Cell Co-Culture.FASEB J202642750492PubTator, text miningPubMed
Composition and Function of Decellularized Human Lung Extracellular Matrix from Congenital Pulmonary Airway Malformation.J Clin Med202642739747PubTator, text miningPubMed
Eugenol preserves chondrocyte extracellular matrix homeostasis by modulating the ALK1/ALK5-associated TGF-β/Smad signaling axis.Front Pharmacol202642723961PubTator, text miningPubMed
In vitro evaluation of hydroxyapatite, β-tricalcium phosphate, graphene oxide and zinc oxide for osteochondral regeneration under inflammatory conditions.Mol Cell Biochem202642709332PubTator, text miningPubMed
A truncated COL10A1 protein causes Schmid metaphyseal chondrodysplasia via protein downregulation and impairing α1 trimer formation and secretion.Funct Integr Genomics202642706449PubTator, text miningPubMed
Expanding the Clinical and Genetic Spectrum of Schmid Metaphyseal Chondrodysplasia: A Seven-Patient Series Including a Rare Homozygous COL10A1 Case.Am J Med Genet A202642678355PubTator, text miningPubMed
Does integrin α10β1 enrichment improve cartilage regeneration? Insights from an in vitro and ex vivo human chondral defect repair model.Knee202642664717PubTator, text miningPubMed

1 to 10 of 2,140

See all 2,140 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1300

GET https://conductscience.org/api/genes/v1/1300/patents?page=2