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Gene · 1311

COMP: cartilage oligomeric matrix protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COMP: cartilage oligomeric matrix protein. Genes, record 1311. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1311

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Gene

Symbol
COMP
HGNC
Name
cartilage oligomeric matrix protein
HGNC
NCBI Gene ID
1311
NCBI Gene
HGNC ID
HGNC:2227
HGNC
Ensembl
ENSG00000105664
NCBI Gene
Aliases
CTS2, EDM1, EPD1, MED, PSACH, THBS5, TSP-5, TSP5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49747Cartilage oligomeric matrix protein7571Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440132P49747Espacenet
JP 2026000906 A2026-01-06291P49747Espacenet
EP 4650780 A22025-11-19547P49747Espacenet
JP 2025147176 A2025-10-063389P49747Espacenet
JP 2025529142 A2025-09-045977P49747Espacenet
JP 2025121919 A2025-08-20163P49747Espacenet
US 12371689 B22025-07-295977P49747Espacenet
JP 2025517970 A2025-06-12547P49747Espacenet
KR 1020250074688 A2025-05-27163P49747Espacenet
JP 2025062604 A2025-04-1412035P49747Espacenet

1 to 10 of 66

See all 66 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants993

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOMP papersNewest fiscal year
P30AG028716Duke Claude D. Pepper Older Americans Independence Center242025
P30CA016672Cancer Center Support Grant62025
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
P30AG024827Pittsburgh Older Americans Independence Center32025
P30AR074992RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE32025
R01NS103931Progranulin: A Novel Gene in Gaucher Diseases32025
UL1TR001998Kentucky Center for Clinical and Translational Science32025
UL1TR002384Clinical and Translational Science Center32025
P30AG021332Wake Forest Claude D. Pepper OAIC - Renewal22025

1 to 10 of 993Source NIH's project files

See all 993 nih grants

Papers2,758

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pre-operative radiological grading and inflammatory mediators as candidate biomarkers of early joint degeneration in patients with femoroacetabular impingement.J Exp Orthop202642788076PubTator, text miningPubMed
Effects of gut microbiota-targeted interventions on pain, physical function, and inflammatory biomarkers in osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Front Cell Infect Microbiol202642761148PubTator, text miningPubMed
The influence of walking speed on the mechanoresponsiveness of biomarkers.Connect Tissue Res202642732455PubTator, text miningPubMed
Systemic and local autoantibody responses to extracellular matrix proteins define inflammatory phenotypes across arthropathies.Rheumatology (Oxford)202642714959PubTator, text miningPubMed
Selenium, Selenoprotein P, and Gut Dysbiosis are Associated with Cartilage Damage in Osteoarthritis Patients.Biol Trace Elem Res202642709376PubTator, text miningPubMed
Oyster hydrolysate attenuates osteoarthritis progression by modulating inflammatory signaling and extracellular matrix homeostasis.Nutr Res Pract202642582610PubTator, text miningPubMed
Cartilage oligomeric matrix protein in pulmonary arterial hypertension associated with lung adenocarcinoma.J Cardiothorac Surg202642469811PubTator, text miningPubMed
Cartilage Oligomeric Matrix Protein (COMP) Correlates with Disease Progression, Selected Immune Checkpoint Molecules and SIGLEC9 in Colorectal Cancer.Int J Mol Sci202642450298PubTator, text miningPubMed
Biological, biomechanical, and pain sensitivity effects of walk-run in people with self-reported knee osteoarthritis.Front Sports Act Living202642367336PubTator, text miningPubMed
Altered post-dance serum cartilage oligomeric matrix protein response in dancers with chronic ankle instability: A pilot study.Medicine (Baltimore)202642299575PubTator, text miningPubMed

1 to 10 of 2,758

See all 2,758 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1311

GET https://conductscience.org/api/genes/v1/1311/patents?page=2