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COMT: catechol-O-methyltransferase

1 protein, 93 patents, 4 drugs, 63 trials, 6,693 NIH grants and 14,671 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCOMTHGNC
Namecatechol-O-methyltransferaseHGNC
NCBI Gene ID1312NCBI Gene
HGNC IDHGNC:2228HGNC
EnsemblENSG00000093010NCBI Gene
AliasesHEL-S-98nNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P21964Catechol O-methyltransferase27112Ensembl, GeneID, HGNCUniProt

Patents 93

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4712986 A12026-03-2548P21964Espacenet
JP 2026004568 A2026-01-1440243P21964Espacenet
JP 2026004568 A2026-01-1440244P21964Espacenet
JP 2026004568 A2026-01-1440245P21964Espacenet
EP 4650780 A22025-11-197877P21964Espacenet
EP 4641201 A22025-10-297978P21964Espacenet
JP 2025529142 A2025-09-041081P21964Espacenet
US 12371689 B22025-07-291081P21964Espacenet
EP 4568684 A12025-06-18453P21964Espacenet
JP 2025517969 A2025-06-127978P21964Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ENTACAPONECHEMBL953Catechol O-methyltransferase inhibitorINHIBITORChEMBL
NEBICAPONECHEMBL160038Catechol O-methyltransferase inhibitorINHIBITORChEMBL
OPICAPONECHEMBL1089318Catechol O-methyltransferase inhibitorINHIBITORChEMBL
TOLCAPONECHEMBL1324Catechol O-methyltransferase inhibitorINHIBITORChEMBL

Trials 63

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07403799OPICAPONEClinicalTrials.gov
NCT07151378ENTACAPONEPHASE3ClinicalTrials.gov
NCT06432309OPICAPONEClinicalTrials.gov
NCT06387771TOLCAPONEPHASE2ClinicalTrials.gov
NCT06236230ENTACAPONEPHASE4ClinicalTrials.gov
NCT05624528TOLCAPONEPHASE2ClinicalTrials.gov
NCT05043103ENTACAPONEClinicalTrials.gov
NCT04990284OPICAPONEPHASE4ClinicalTrials.gov
NCT04986995OPICAPONEPHASE4ClinicalTrials.gov
NCT04986982OPICAPONEPHASE42025-03-28ClinicalTrials.gov

NIH grants 6693

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAAA000301Integrative genetics of behavior with high throughput technologies482,025NIH's project files
P30AG028740University of Florida Older Americans Independence Center (OAIC)242,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology232,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant222,025NIH's project files
P30CA008748Cancer Center Support Grant192,025NIH's project files
T32MH020030ResearchTraining: Psychiatric and Statistical Genetics142,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award142,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)122,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility122,025NIH's project files
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).122,025NIH's project files

Papers 14671

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42801895PubTator, text miningPubMed
42797389PubTator, text miningPubMed
42793386PubTator, text miningPubMed
42792671PubTator, text miningPubMed
42782389PubTator, text miningPubMed
42764871PubTator, text miningPubMed
42748150PubTator, text miningPubMed
42745750PubTator, text miningPubMed
42742115PubTator, text miningPubMed
42730819PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license