ConductScience.org, home

Gene · 1314

COPA: coat protein complex I subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. COPA: coat protein complex I subunit alpha. Genes, record 1314. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1314

On this page

Gene

Symbol
COPA
HGNC
Name
coat protein complex I subunit alpha
HGNC
NCBI Gene ID
1314
NCBI Gene
HGNC ID
HGNC:2230
HGNC
Ensembl
ENSG00000122218
NCBI Gene
Aliases
AIAISD, AIAISD1, AILJK, HEP-COP, alpha-COP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P53621Coatomer subunit alpha1,2243Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441715P53621Espacenet
EP 4650780 A22025-11-191048P53621Espacenet
EP 4641201 A22025-10-29735P53621Espacenet
JP 2025517969 A2025-06-12735P53621Espacenet
JP 2025517970 A2025-06-121048P53621Espacenet
US 12239743 B22025-03-0415P53621Espacenet
US 12239743 B22025-03-0416P53621Espacenet
US 11446398 B22022-09-2017913P53621Espacenet
JP 2022524081 A2022-04-27120884P53621Espacenet
US 11235062 B22022-02-015P53621Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants938

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOPA papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
R01DK071865Molecular Mechanisms of Active Copper Transport52025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control42025
P30CA008748Cancer Center Support Grant32025
P30CA016086Cancer Center Support Grant32025
P30DK020579Diabetes Research Center32025
P30DK056341Washington University Nutrition Obesity Research Center32025
R01AI073843Pathobiology of heme inducible transporters in Gram positive pathogens32025
R35GM128704Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteins32025
R37GM058615Mechanisms and Physiology of COPI Transport32025

1 to 10 of 938Source NIH's project files

See all 938 nih grants

Papers1,296

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Serum COPA for the diagnosis and immunotherapeutic monitoring of hepatocellular carcinoma: a retrospective study.Front Pharmacol202642699457PubTator, text miningPubMed
A Rare Case of COPA Syndrome: Multisystem Relapse and Fatal Septic Complication.Respirol Case Rep202642698744PubTator, text miningPubMed
The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion.Atherosclerosis202642667864PubTator, text miningPubMed
Bile extracellular vesicles for early cholangiocarcinoma detection in primary sclerosing cholangitis.JHEP Rep202642628796PubTator, text miningPubMed
Evaluation of CPP and LDH nanocarriers for dsRNA efficiency in Brassicogethes aeneus.Front Insect Sci202642614463PubTator, text miningPubMed
Type I Interferonopathies in the Differential Diagnosis of Vasculitis: A Comprehensive Review.J Vis Exp202642611810PubTator, text miningPubMed
Interstitial Lung Disease in Children: Rare Genetic Variants Beyond Surfactant Dysfunction.Pediatr Pulmonol202642598967PubTator, text miningPubMed
COPI Coatomer Regulates Several Steps of HDL Metabolism.Arterioscler Thromb Vasc Biol202642592650PubTator, text miningPubMed
Distinct roles of COPI proteins attenuated in cell senescence.Sci Adv202642490423PubTator, text miningPubMed
Baricitinib in two paediatric patients with coatomer subunit alpha (COPA) syndrome: A case series and literature review.Mod Rheumatol Case Rep202642340344PubTator, text miningPubMed

1 to 10 of 1,296

See all 1,296 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1314

GET https://conductscience.org/api/genes/v1/1314/patents?page=2