Gene · 1314
COPA: coat protein complex I subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. COPA: coat protein complex I subunit alpha. Genes, record 1314. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1314
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P53621 | Coatomer subunit alpha | 1,224 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 41715 | P53621 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1048 | P53621 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 735 | P53621 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 735 | P53621 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1048 | P53621 | Espacenet |
| US 12239743 B2 | 2025-03-04 | 15 | P53621 | Espacenet |
| US 12239743 B2 | 2025-03-04 | 16 | P53621 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 17913 | P53621 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 120884 | P53621 | Espacenet |
| US 11235062 B2 | 2022-02-01 | 5 | P53621 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants938
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | COPA papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| R01DK071865 | Molecular Mechanisms of Active Copper Transport | 5 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020579 | Diabetes Research Center | 3 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 3 | 2025 |
| R01AI073843 | Pathobiology of heme inducible transporters in Gram positive pathogens | 3 | 2025 |
| R35GM128704 | Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteins | 3 | 2025 |
| R37GM058615 | Mechanisms and Physiology of COPI Transport | 3 | 2025 |
1 to 10 of 938Source NIH's project files
See all 938 nih grantsPapers1,296
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Serum COPA for the diagnosis and immunotherapeutic monitoring of hepatocellular carcinoma: a retrospective study. | Front Pharmacol | 2026 | 42699457 | PubTator, text mining | PubMed |
| A Rare Case of COPA Syndrome: Multisystem Relapse and Fatal Septic Complication. | Respirol Case Rep | 2026 | 42698744 | PubTator, text mining | PubMed |
| The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion. | Atherosclerosis | 2026 | 42667864 | PubTator, text mining | PubMed |
| Bile extracellular vesicles for early cholangiocarcinoma detection in primary sclerosing cholangitis. | JHEP Rep | 2026 | 42628796 | PubTator, text mining | PubMed |
| Evaluation of CPP and LDH nanocarriers for dsRNA efficiency in Brassicogethes aeneus. | Front Insect Sci | 2026 | 42614463 | PubTator, text mining | PubMed |
| Type I Interferonopathies in the Differential Diagnosis of Vasculitis: A Comprehensive Review. | J Vis Exp | 2026 | 42611810 | PubTator, text mining | PubMed |
| Interstitial Lung Disease in Children: Rare Genetic Variants Beyond Surfactant Dysfunction. | Pediatr Pulmonol | 2026 | 42598967 | PubTator, text mining | PubMed |
| COPI Coatomer Regulates Several Steps of HDL Metabolism. | Arterioscler Thromb Vasc Biol | 2026 | 42592650 | PubTator, text mining | PubMed |
| Distinct roles of COPI proteins attenuated in cell senescence. | Sci Adv | 2026 | 42490423 | PubTator, text mining | PubMed |
| Baricitinib in two paediatric patients with coatomer subunit alpha (COPA) syndrome: A case series and literature review. | Mod Rheumatol Case Rep | 2026 | 42340344 | PubTator, text mining | PubMed |
1 to 10 of 1,296
See all 1,296 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1314
GET https://conductscience.org/api/genes/v1/1314/patents?page=2