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Gene · 1316

KLF6: KLF transcription factor 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KLF6: KLF transcription factor 6. Genes, record 1316. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1316

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Gene

Symbol
KLF6
HGNC
Name
KLF transcription factor 6
HGNC
NCBI Gene ID
1316
NCBI Gene
HGNC ID
HGNC:2235
HGNC
Ensembl
ENSG00000067082
NCBI Gene
Aliases
BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9, Zf9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99612Krueppel-like factor 62830Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16705Q99612Espacenet
EP 4705462 A22026-03-11131Q99612Espacenet
JP 2026004568 A2026-01-1450975Q99612Espacenet
EP 4650780 A22025-11-1914383Q99612Espacenet
JP 2025147176 A2025-10-0615220Q99612Espacenet
JP 2025517970 A2025-06-1214383Q99612Espacenet
JP 2025028160 A2025-02-2815220Q99612Espacenet
KR 1020250010750 A2025-01-2115220Q99612Espacenet
JP 2024534404 A2024-09-2092Q99612Espacenet
JP 2024109657 A2024-08-1415059Q99612Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,888

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKLF6 papersNewest fiscal year
P30CA016672Cancer Center Support Grant132025
P30CA008748Cancer Center Support Grant62025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)52025
P30CA016042Cancer Center Support Grant42025
P30CA034196Cancer Center Support (CORE) Grant42025
P30CA068485Cancer Center Support Grant42025
P30EY014800University of Utah Core Vision Research Grant42025
P30EY014801Miami Center for Vision Research42025
P50CA097186The Pacific Northwest Prostate Cancer SPORE42025
R01DK052230Regulation of Intestinal Epithelial Cell Proliferation42025

1 to 10 of 1,888Source NIH's project files

See all 1,888 nih grants

Papers2,770

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cysteine supplementation reverses immune dysfunction in cancer patients with severe COVID-19.medRxiv202642818159PubTator, text miningPubMed
Integrated chromatin accessibility and transcriptomic profiling provide insights into inflammation-associated endothelial remodeling in capillary malformations.Cell Signal Inflamm Dis202642788004PubTator, text miningPubMed
Biochanin A promotes KLF6 stabilization to induce ferroptosis and suppress colorectal cancer progression.Cell Signal202642754129PubTator, text miningPubMed
KLF transcription factors in metabolic kidney disease: from podocyte protection to tubulointerstitial fibrosis.Int Urol Nephrol202642753072PubTator, text miningPubMed
Analysis of Allele-Specific Expression Highlights Novel Participants of Empagliflozin-Driven Effects on T2DM-Associated Regulatory Pathways.Int J Mol Sci202642653207PubTator, text miningPubMed
Design, synthesis, and preliminary antiproliferative evaluation of azetidine-functionalized pyrrolo[2,3-d]pyrimidines with integrated computational studies.J Biomol Struct Dyn202642627359PubTator, text miningPubMed
Regulatory roles and translational potential of the Kruppel-like factor family in liver disease.ILIVER202642598083PubTator, text miningPubMed
KLF6-driven macrophage-to-myofibroblast transition promotes PD-L1-mediated immune evasion in bladder cancer.Int Immunopharmacol202642574804PubTator, text miningPubMed
Inhalable Mucoadhesive Redox-Triggered Nanotherapeutics for p53-Mediated Lung Cancer Therapy and Metastasis Suppression.Adv Healthc Mater202642498986PubTator, text miningPubMed
Mesothelial cell senescence induced by high glucose in peritoneal dialysis drives fibroblast activation and peritoneal fibrosis through KLF6-mediated activation of TGF-β pathway.Mol Cell Biochem202642418120PubTator, text miningPubMed

1 to 10 of 2,770

See all 2,770 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1316

GET https://conductscience.org/api/genes/v1/1316/patents?page=2