ConductScience.org, home

Gene · 1326

MAP3K8: mitogen-activated protein kinase kinase kinase 8

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. MAP3K8: mitogen-activated protein kinase kinase kinase 8. Genes, record 1326. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1326

On this page

Gene

Symbol
MAP3K8
HGNC
Name
mitogen-activated protein kinase kinase kinase 8
HGNC
NCBI Gene ID
1326
NCBI Gene
HGNC ID
HGNC:6860
HGNC
Ensembl
ENSG00000107968
NCBI Gene
Aliases
AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41279Mitogen-activated protein kinase kinase kinase 84673Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453996P41279Espacenet
JP 2026004568 A2026-01-1453997P41279Espacenet
JP 2026004568 A2026-01-1453999P41279Espacenet
JP 2026004568 A2026-01-1454003P41279Espacenet
EP 4650780 A22025-11-192157P41279Espacenet
JP 2025517970 A2025-06-122157P41279Espacenet
US 12173039 B12024-12-2439P41279Espacenet
JP 2024121274 A2024-09-0612P41279Espacenet
WO 2023080157 A2023-05-111P41279Espacenet
US 11446398 B22022-09-2052585P41279Espacenet

1 to 10 of 54

See all 54 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
TILPISERTIBCHEMBL4802154Mitogen-activated protein kinase kinase kinase 8 inhibitorINHIBITOR

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT04130919TILPISERTIBPHASE22022-08-24

NIH grants1,474

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAP3K8 papersNewest fiscal year
P30CA016672Cancer Center Support Grant212025
P30CA008748Cancer Center Support Grant142025
P30CA076292Moffitt Cancer Center Support Grant142025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment122025
UL1TR001863Yale Clinical and Translational Science Award72025
P30CA010815Consolidated Basic Cancer Research Program52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P50CA058223SPORE in Breast Cancer52025
ZIAAR041159Cytokine Signaling, Immunoregulation and Autoimmune and Immunodeficiency Diseases52025
K12CA090625Vanderbilt Clinical Oncology Research Career Development Award42025

1 to 10 of 1,474Source NIH's project files

See all 1,474 nih grants

Papers2,267

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Free energy perturbation and machine learning-assisted identification of potential MAP3K8 hit molecules: a comprehensive structure- and ligand-based studies.Mol Divers202642584524PubTator, text miningPubMed
Single-cell immune landscape of patients with different ovarian reserves during COH.Funct Integr Genomics202642533238PubTator, text miningPubMed
Morphology-associated ocular surface toxicity of micro- and nanoplastics: Fiber embedding contributes to persistent injury.Ecotoxicol Environ Saf202642413336PubTator, text miningPubMed
Clinical, morphological, and genomic features of FGFR fusion Spitz neoplasms.Pathology202642342463PubTator, text miningPubMed
Correction to: ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism.J Immunol202642300803PubTator, text miningPubMed
Excited-state dissociation of (η4-diene)Ru(CO)3 precursors for photo-assisted chemical vapour deposition.Phys Chem Chem Phys202642300187PubTator, text miningPubMed
Say It My Way: Exploring Control in Conversational Visual Question Answering with Blind Users.Proc SIGCHI Conf Hum Factor Comput Syst202642239733PubTator, text miningPubMed
Exploring hypoxia-related genes as prognostic indicators in lung adenocarcinoma.PLoS One202642234659PubTator, text miningPubMed
Gene fusions in melanocytic lesions: an updated comprehensive review.J Pathol Transl Med202642098956PubTator, text miningPubMed
Key Toxic Genes and Mechanisms of Di(2-ethylhexyl) Phthalate-Induced Non-Alcoholic Fatty Liver Disease: A Multi-Omics Study.Curr Med Chem202642051095PubTator, text miningPubMed

1 to 10 of 2,267

See all 2,267 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1326

GET https://conductscience.org/api/genes/v1/1326/patents?page=2