Gene · 1326
MAP3K8: mitogen-activated protein kinase kinase kinase 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MAP3K8: mitogen-activated protein kinase kinase kinase 8. Genes, record 1326. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1326
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P41279 | Mitogen-activated protein kinase kinase kinase 8 | 467 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents54
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 53996 | P41279 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 53997 | P41279 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 53999 | P41279 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 54003 | P41279 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2157 | P41279 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2157 | P41279 | Espacenet |
| US 12173039 B1 | 2024-12-24 | 39 | P41279 | Espacenet |
| JP 2024121274 A | 2024-09-06 | 12 | P41279 | Espacenet |
| WO 2023080157 A | 2023-05-11 | 1 | P41279 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 52585 | P41279 | Espacenet |
1 to 10 of 54
See all 54 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| TILPISERTIB | CHEMBL4802154 | Mitogen-activated protein kinase kinase kinase 8 inhibitor | INHIBITOR |
Source ChEMBL
Trials1
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted |
|---|---|---|---|
| NCT04130919 | TILPISERTIB | PHASE2 | 2022-08-24 |
Source ClinicalTrials.gov
NIH grants1,474
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MAP3K8 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 21 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 14 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 14 | 2025 |
| P01CA163222 | Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment | 12 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 7 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 5 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| P50CA058223 | SPORE in Breast Cancer | 5 | 2025 |
| ZIAAR041159 | Cytokine Signaling, Immunoregulation and Autoimmune and Immunodeficiency Diseases | 5 | 2025 |
| K12CA090625 | Vanderbilt Clinical Oncology Research Career Development Award | 4 | 2025 |
1 to 10 of 1,474Source NIH's project files
See all 1,474 nih grantsPapers2,267
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Free energy perturbation and machine learning-assisted identification of potential MAP3K8 hit molecules: a comprehensive structure- and ligand-based studies. | Mol Divers | 2026 | 42584524 | PubTator, text mining | PubMed |
| Single-cell immune landscape of patients with different ovarian reserves during COH. | Funct Integr Genomics | 2026 | 42533238 | PubTator, text mining | PubMed |
| Morphology-associated ocular surface toxicity of micro- and nanoplastics: Fiber embedding contributes to persistent injury. | Ecotoxicol Environ Saf | 2026 | 42413336 | PubTator, text mining | PubMed |
| Clinical, morphological, and genomic features of FGFR fusion Spitz neoplasms. | Pathology | 2026 | 42342463 | PubTator, text mining | PubMed |
| Correction to: ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism. | J Immunol | 2026 | 42300803 | PubTator, text mining | PubMed |
| Excited-state dissociation of (η4-diene)Ru(CO)3 precursors for photo-assisted chemical vapour deposition. | Phys Chem Chem Phys | 2026 | 42300187 | PubTator, text mining | PubMed |
| Say It My Way: Exploring Control in Conversational Visual Question Answering with Blind Users. | Proc SIGCHI Conf Hum Factor Comput Syst | 2026 | 42239733 | PubTator, text mining | PubMed |
| Exploring hypoxia-related genes as prognostic indicators in lung adenocarcinoma. | PLoS One | 2026 | 42234659 | PubTator, text mining | PubMed |
| Gene fusions in melanocytic lesions: an updated comprehensive review. | J Pathol Transl Med | 2026 | 42098956 | PubTator, text mining | PubMed |
| Key Toxic Genes and Mechanisms of Di(2-ethylhexyl) Phthalate-Induced Non-Alcoholic Fatty Liver Disease: A Multi-Omics Study. | Curr Med Chem | 2026 | 42051095 | PubTator, text mining | PubMed |
1 to 10 of 2,267
See all 2,267 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1326
GET https://conductscience.org/api/genes/v1/1326/patents?page=2