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ADORA2A: adenosine A2a receptor

1 protein, 125 patents, 31 drugs, 353 trials, 3,485 NIH grants and 7,223 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolADORA2AHGNC
Nameadenosine A2a receptorHGNC
NCBI Gene ID135NCBI Gene
HGNC IDHGNC:263HGNC
EnsemblENSG00000128271NCBI Gene
AliasesA2aR, ADORA2, RDC8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29274Adenosine receptor A2a412188Ensembl, GeneID, HGNCUniProt

Patents 125

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026053553 A2026-03-25164P29274Espacenet
JP 2026004568 A2026-01-1436617P29274Espacenet
JP 2026004568 A2026-01-1436618P29274Espacenet
JP 2026004568 A2026-01-1436623P29274Espacenet
WO 2025257365 A12025-12-181P29274Espacenet
JP 2025529142 A2025-09-04328P29274Espacenet
US 12371689 B22025-07-29328P29274Espacenet
JP 2025511270 A2025-04-15100P29274Espacenet
JP 2025062604 A2025-04-142674P29274Espacenet
EP 4516806 A22025-03-05164P29274Espacenet

Drugs 31

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADENOSINECHEMBL477Adenosine receptor agonistAGONISTChEMBL
AMINOPHYLLINECHEMBL1370561Adenosine receptor antagonistANTAGONISTChEMBL
AMP579CHEMBL3545163Adenosine A2a receptor agonistAGONISTChEMBL
APADENOSONCHEMBL1950649Adenosine A2a receptor agonistAGONISTChEMBL
BINODENOSONCHEMBL1950554Adenosine A2a receptor agonistAGONISTChEMBL
BVT.115959CHEMBL470888Adenosine A2a receptor agonistAGONISTChEMBL
CAFFEINECHEMBL113Adenosine receptor antagonistANTAGONISTChEMBL
CAFFEINE CITRATECHEMBL1200569Adenosine receptor antagonistANTAGONISTChEMBL
CIFORADENANTCHEMBL4297184Adenosine A2a receptor antagonistANTAGONISTChEMBL
DEFIBROTIDECHEMBL2108396Adenosine A2 receptor agonistAGONISTChEMBL

Trials 353

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07469852CAFFEINEPHASE1/PHASE2ClinicalTrials.gov
NCT07466732CAFFEINEEARLY_PHASE1ClinicalTrials.gov
NCT07456670CAFFEINEPHASE2ClinicalTrials.gov
NCT07349472PENTOXIFYLLINEPHASE2ClinicalTrials.gov
NCT07348510AMINOPHYLLINEClinicalTrials.gov
NCT07315139PENTOXIFYLLINEClinicalTrials.gov
NCT07262060CAFFEINE CITRATEPHASE2ClinicalTrials.gov
NCT07252518PENTOXIFYLLINEClinicalTrials.gov
NCT07216365CAFFEINE CITRATEPHASE2ClinicalTrials.gov
NCT07088328PENTOXIFYLLINEClinicalTrials.gov

NIH grants 3485

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS542,025NIH's project files
ZIADK031117Development of Drugs Acting at Adenosine Receptors262,025NIH's project files
P30CA008748Cancer Center Support Grant162,025NIH's project files
P30CA016672Cancer Center Support Grant112,025NIH's project files
T32HL007849Cardiovascular Surgery Training Program112,025NIH's project files
UL1TR001445Clinical and Translational Science Award102,025NIH's project files
P30CA016087Cancer Center Support Grant92,025NIH's project files
R01MH054137Structure and Function of Dopamine Receptors92,025NIH's project files
ZIADK031115Functionalized Congeners of Bioactive Compounds82,025NIH's project files
P30CA006973Regional Oncology Research Center72,025NIH's project files

Papers 7223

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826708PubTator, text miningPubMed
42800225PubTator, text miningPubMed
42791917PubTator, text miningPubMed
42764871PubTator, text miningPubMed
42728132PubTator, text miningPubMed
42707968PubTator, text miningPubMed
42673863PubTator, text miningPubMed
42666453PubTator, text miningPubMed
42660457PubTator, text miningPubMed
42653309PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license