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Gene · 1364

CLDN4: claudin 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CLDN4: claudin 4. Genes, record 1364. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1364

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Gene

Symbol
CLDN4
HGNC
Name
claudin 4
HGNC
NCBI Gene ID
1364
NCBI Gene
HGNC ID
HGNC:2046
HGNC
Ensembl
ENSG00000189143
NCBI Gene
Aliases
CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14493Claudin-42098Ensembl, GeneID, HGNC

Source UniProt

Patents170

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026126292 A2026-08-046O14493Espacenet
JP 2026126293 A2026-08-046O14493Espacenet
JP 2026004568 A2026-01-1441659O14493Espacenet
JP 2026004568 A2026-01-1441660O14493Espacenet
JP 2026004568 A2026-01-1441661O14493Espacenet
JP 2025529142 A2025-09-04989O14493Espacenet
US 12403202 B22025-09-026O14493Espacenet
JP 2025527491 A2025-08-2294O14493Espacenet
JP 2025122026 A2025-08-206O14493Espacenet
JP 2025122027 A2025-08-206O14493Espacenet

1 to 10 of 170

See all 170 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,708

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCLDN4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant162025
P30CA008748Cancer Center Support Grant142025
P30CA068485Cancer Center Support Grant122025
P30DK058404Molecular and Cellular Basis for Digestive Diseases122025
R01DK061931Mechanisms and pathophysiologic impact of claudin-2 modulation122025
R01DK068271Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.122025
P30CA046934University of Colorado Cancer Center Support Grant112025
R35GM138368Structure and Assembly of Membrane Proteins at Tight Junctions102025
P30DK034987Center for Gastrointestinal Biology and Disease72025
P50CA058223SPORE in Breast Cancer72025

1 to 10 of 1,708Source NIH's project files

See all 1,708 nih grants

Papers3,919

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Rare Case of Poorly Differentiated Synovial Sarcoma of the Superficial Neck: Diagnostic Approach in a Fine-Needle Aspiration Specimen.Diagn Cytopathol202642808294PubTator, text miningPubMed
Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps Associated with Allergic Sensitization.Int J Mol Sci202642737845PubTator, text miningPubMed
Epithelioid Enigma: Proximal-Type Epithelioid Sarcoma in Cyst Fluid Cytology.Diagn Cytopathol202642713918PubTator, text miningPubMed
Soluble adenylyl cyclase regulates tight junctions of human intestinal epithelial cells via claudin-4.Am J Physiol Gastrointest Liver Physiol202642691479PubTator, text miningPubMed
A clinically derived lipid-endothelial signature links serum multi-omics to immune exclusion and clinical stratification in hepatocellular carcinoma.Ther Adv Med Oncol202642682961PubTator, text miningPubMed
Tight junction-related proteins in the upper reproductive tract luminal and glandular epithelial cells are regionally regulated across the estrous cycle.Front Endocrinol (Lausanne)202642676457PubTator, text miningPubMed
CK8/18 and Claudin Profile of Female Breast Cancers from Botswana.Breast Cancer (Auckl)202642668738PubTator, text miningPubMed
Evaluating the potential of foodborne chemicals to modulate intestinal barrier function: a combined in vitro/in silico toolbox to study the effects on tight junction protein claudin-4.Food Res Int202642637315PubTator, text miningPubMed
Integrative multi-omics analysis identifies an enhancer-driven ELF3-CLDN4 regulatory axis that shapes an immunosuppressive microenvironment and predicts prognosis in high-grade serous ovarian cancer.Gene202642624178PubTator, text miningPubMed
Use of tight junction binders to analyze the barrier function of human placental JEG-3 cells.Placenta202642612291PubTator, text miningPubMed

1 to 10 of 3,919

See all 3,919 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1364

GET https://conductscience.org/api/genes/v1/1364/patents?page=2