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Gene · 1365

CLDN3: claudin 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CLDN3: claudin 3. Genes, record 1365. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1365

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Gene

Symbol
CLDN3
HGNC
Name
claudin 3
HGNC
NCBI Gene ID
1365
NCBI Gene
HGNC ID
HGNC:2045
HGNC
Ensembl
ENSG00000165215
NCBI Gene
Aliases
C7orf1, CPE-R2, CPETR2, HRVP1, RVP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15551Claudin-32200Ensembl, GeneID, HGNC

Source UniProt

Patents157

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026126292 A2026-08-045O15551Espacenet
JP 2026126293 A2026-08-045O15551Espacenet
JP 2026004568 A2026-01-1441658O15551Espacenet
JP 2025529142 A2025-09-04988O15551Espacenet
US 12403202 B22025-09-025O15551Espacenet
WO 2025177214 A12025-08-2822O15551Espacenet
JP 2025122026 A2025-08-205O15551Espacenet
JP 2025122027 A2025-08-205O15551Espacenet
US 12371689 B22025-07-29988O15551Espacenet
JP 2025521567 A2025-07-104O15551Espacenet

1 to 10 of 157

See all 157 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,332

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCLDN3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30DK058404Molecular and Cellular Basis for Digestive Diseases92025
P50CA058223SPORE in Breast Cancer82025
P30CA068485Cancer Center Support Grant72025
P30CA016359Cancer Center Support Grant62025
R01DK057819Intestinal Mucosal Growth in Health and Surgical Diseases62025
UL1TR001863Yale Clinical and Translational Science Award62025
P30CA046934University of Colorado Cancer Center Support Grant52025
I01BX000332Posttranscriptional Control of Gut Mucosal Defense and Homeostasis42025
P30CA008748Cancer Center Support Grant42025

1 to 10 of 1,332Source NIH's project files

See all 1,332 nih grants

Papers2,896

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TGM2 Activates the ERK Signaling Pathway to Disrupt Intestinal Barrier Function and Aggravate Colitis.Front Biosci (Landmark Ed)202642811980PubTator, text miningPubMed
Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps Associated with Allergic Sensitization.Int J Mol Sci202642737845PubTator, text miningPubMed
Nicastrin Regulates Cutaneous Squamous Cell Carcinoma Progression Through the MAPK/ERK Signalling.Exp Dermatol202642712002PubTator, text miningPubMed
Probiotics and intestinal permeability in adults with metabolic dysfunction-associated steatohepatitis: A secondary analysis of a randomized clinical trial.JPEN J Parenter Enteral Nutr202642701874PubTator, text miningPubMed
Tight junction-related proteins in the upper reproductive tract luminal and glandular epithelial cells are regionally regulated across the estrous cycle.Front Endocrinol (Lausanne)202642676457PubTator, text miningPubMed
CK8/18 and Claudin Profile of Female Breast Cancers from Botswana.Breast Cancer (Auckl)202642668738PubTator, text miningPubMed
Breaking the Barrier: Pro-inflammatory Stool from Infants with CHD Triggers Barrier Dysfunction within Intestinal Organoids.Res Sq202642619927PubTator, text miningPubMed
Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer.bioRxiv202642619739PubTator, text miningPubMed
Single-Cell Profiling Identifies the SPDEF/GAS5 Axis as a Potential Driver of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer.Cureus202642528776PubTator, text miningPubMed
Impact of Deoxynivalenol, Cytokines, and Particulate Matter on Human Trophoblast Cells.Int J Mol Sci202642511775PubTator, text miningPubMed

1 to 10 of 2,896

See all 2,896 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1365

GET https://conductscience.org/api/genes/v1/1365/patents?page=2