Gene · 1373
CPS1: carbamoyl-phosphate synthase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CPS1: carbamoyl-phosphate synthase 1. Genes, record 1373. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1373
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P31327 | Carbamoyl-phosphate synthase [ammonia], mitochondrial | 1,500 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents75
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 62 | P31327 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 839 | P31327 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 878 | P31327 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 97 | P31327 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 590 | P31327 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 97 | P31327 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 590 | P31327 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 839 | P31327 | Espacenet |
| US 12281323 B2 | 2025-04-22 | 1 | P31327 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 11642 | P31327 | Espacenet |
1 to 10 of 75
See all 75 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| CARGLUMIC ACID | CHEMBL1201780 | Carbamoyl-phosphate synthase [ammonia], mitochondrial positive allosteric modulator | POSITIVE ALLOSTERIC MODULATOR |
Source ChEMBL
Trials8
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05040178 | CARGLUMIC ACID | ClinicalTrials.gov | ||
| NCT04284917 | CARGLUMIC ACID | ClinicalTrials.gov | ||
| NCT04176523 | CARGLUMIC ACID | ClinicalTrials.gov | ||
| NCT02426775 | CARGLUMIC ACID | PHASE3 | ClinicalTrials.gov | |
| NCT01599286 | CARGLUMIC ACID | PHASE2 | 2021-02-15 | ClinicalTrials.gov |
| NCT01597440 | CARGLUMIC ACID | PHASE2 | 2017-04-26 | ClinicalTrials.gov |
| NCT01341379 | CARGLUMIC ACID | PHASE2 | ClinicalTrials.gov | |
| NCT00843921 | CARGLUMIC ACID | PHASE2/PHASE3 | ClinicalTrials.gov |
NIH grants1,662
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CPS1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 7 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 7 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P30DK116074 | Stanford Diabetes Research Center | 4 | 2025 |
| ZIAHL006170 | Cardiovascular Genomics and Bioinformatics projects | 4 | 2025 |
| P30DK026743 | UCSF Liver Center | 3 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 3 | 2025 |
1 to 10 of 1,662Source NIH's project files
See all 1,662 nih grantsPapers2,057
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Multiple Phosphonate Degradation Pathways in Amphidinium carterae-Associated Bacteria Potentially Contribute to Host Adaptation to Phosphorus Limitation. | Microorganisms | 2026 | 42795609 | PubTator, text mining | PubMed |
| Clinical, Biochemical, and Molecular Analyses of Three Patients with Urea Cycle Disorders in China. | Ann Clin Lab Sci | 2026 | 42790946 | PubTator, text mining | PubMed |
| Genipin induces liver injury by disrupting the CPS1-regulated urea cycle and redox homeostasis. | J Pharm Anal | 2026 | 42787309 | PubTator, text mining | PubMed |
| Fate of long-term culture on hepatocyte-like cells generated from human adipose-derived mesenchymal stem cells. | Stem Cells Transl Med | 2026 | 42759067 | PubTator, text mining | PubMed |
| Machine learning-based identification of core regulatory targets in 1-nitropyrene-induced placental trophoblast dysfunction and FGR. | Ecotoxicol Environ Saf | 2026 | 42735479 | PubTator, text mining | PubMed |
| A de novo 1.62 Mb deletion at 2q34 with nonpenetrant neurodevelopmental phenotype at 12 months. | Psychiatr Genet | 2026 | 42704312 | PubTator, text mining | PubMed |
| Integrated multi-omics analysis of metabolomics and proteomics uncovers dysregulated amino acid metabolism in HCC metastasis. | Front Immunol | 2026 | 42688489 | PubTator, text mining | PubMed |
| CPS1 promotes colorectal cancer progression by inducing EMT and activating TGF-β/Smad signaling pathway. | iScience | 2026 | 42621110 | PubTator, text mining | PubMed |
| Three-dimensional organoid culture enhances functional maturation of human pluripotent stem cell-derived hepatocytes. | Mol Biol Rep | 2026 | 42525161 | PubTator, text mining | PubMed |
| A deep intronic CPS1 variant causing pseudo-exon activation identified in an adult with molecularly unconfirmed urea cycle disorder. | Biochem Biophys Res Commun | 2026 | 42485798 | PubTator, text mining | PubMed |
1 to 10 of 2,057
See all 2,057 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1373
GET https://conductscience.org/api/genes/v1/1373/patents?page=2