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Gene · 1373

CPS1: carbamoyl-phosphate synthase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CPS1: carbamoyl-phosphate synthase 1. Genes, record 1373. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1373

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Gene

Symbol
CPS1
HGNC
Name
carbamoyl-phosphate synthase 1
HGNC
NCBI Gene ID
1373
NCBI Gene
HGNC ID
HGNC:2323
HGNC
Ensembl
ENSG00000021826
NCBI Gene
Aliases
CPS1D, CPSASE1, GATD6, PHN
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P31327Carbamoyl-phosphate synthase [ammonia], mitochondrial1,50014Ensembl, GeneID, HGNC

Source UniProt

Patents75

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-2162P31327Espacenet
EP 4650780 A22025-11-19839P31327Espacenet
JP 2025169942 A2025-11-14878P31327Espacenet
EP 4640849 A22025-10-2997P31327Espacenet
EP 4641201 A22025-10-29590P31327Espacenet
JP 2025519096 A2025-06-2497P31327Espacenet
JP 2025517969 A2025-06-12590P31327Espacenet
JP 2025517970 A2025-06-12839P31327Espacenet
US 12281323 B22025-04-221P31327Espacenet
JP 2025062604 A2025-04-1411642P31327Espacenet

1 to 10 of 75

See all 75 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
CARGLUMIC ACIDCHEMBL1201780Carbamoyl-phosphate synthase [ammonia], mitochondrial positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATOR

Source ChEMBL

Trials8

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05040178CARGLUMIC ACIDClinicalTrials.gov
NCT04284917CARGLUMIC ACIDClinicalTrials.gov
NCT04176523CARGLUMIC ACIDClinicalTrials.gov
NCT02426775CARGLUMIC ACIDPHASE3ClinicalTrials.gov
NCT01599286CARGLUMIC ACIDPHASE22021-02-15ClinicalTrials.gov
NCT01597440CARGLUMIC ACIDPHASE22017-04-26ClinicalTrials.gov
NCT01341379CARGLUMIC ACIDPHASE2ClinicalTrials.gov
NCT00843921CARGLUMIC ACIDPHASE2/PHASE3ClinicalTrials.gov

NIH grants1,662

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCPS1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30DK020572Michigan Diabetes Research Center (MDRC)72025
P30DK063491Diabetes Research Center (DRC)72025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal62025
P30CA016672Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant42025
P30DK116074Stanford Diabetes Research Center42025
ZIAHL006170Cardiovascular Genomics and Bioinformatics projects42025
P30DK026743UCSF Liver Center32025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital32025

1 to 10 of 1,662Source NIH's project files

See all 1,662 nih grants

Papers2,057

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multiple Phosphonate Degradation Pathways in Amphidinium carterae-Associated Bacteria Potentially Contribute to Host Adaptation to Phosphorus Limitation.Microorganisms202642795609PubTator, text miningPubMed
Clinical, Biochemical, and Molecular Analyses of Three Patients with Urea Cycle Disorders in China.Ann Clin Lab Sci202642790946PubTator, text miningPubMed
Genipin induces liver injury by disrupting the CPS1-regulated urea cycle and redox homeostasis.J Pharm Anal202642787309PubTator, text miningPubMed
Fate of long-term culture on hepatocyte-like cells generated from human adipose-derived mesenchymal stem cells.Stem Cells Transl Med202642759067PubTator, text miningPubMed
Machine learning-based identification of core regulatory targets in 1-nitropyrene-induced placental trophoblast dysfunction and FGR.Ecotoxicol Environ Saf202642735479PubTator, text miningPubMed
A de novo 1.62 Mb deletion at 2q34 with nonpenetrant neurodevelopmental phenotype at 12 months.Psychiatr Genet202642704312PubTator, text miningPubMed
Integrated multi-omics analysis of metabolomics and proteomics uncovers dysregulated amino acid metabolism in HCC metastasis.Front Immunol202642688489PubTator, text miningPubMed
CPS1 promotes colorectal cancer progression by inducing EMT and activating TGF-β/Smad signaling pathway.iScience202642621110PubTator, text miningPubMed
Three-dimensional organoid culture enhances functional maturation of human pluripotent stem cell-derived hepatocytes.Mol Biol Rep202642525161PubTator, text miningPubMed
A deep intronic CPS1 variant causing pseudo-exon activation identified in an adult with molecularly unconfirmed urea cycle disorder.Biochem Biophys Res Commun202642485798PubTator, text miningPubMed

1 to 10 of 2,057

See all 2,057 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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