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CR1: complement C3b/C4b receptor 1 (Knops blood group)

1 protein, 28 patents, 1 drug, 0 trials, 4,405 NIH grants and 7,844 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCR1HGNC
Namecomplement C3b/C4b receptor 1 (Knops blood group)HGNC
NCBI Gene ID1378NCBI Gene
HGNC IDHGNC:2334HGNC
EnsemblENSG00000203710NCBI Gene
AliasesC3BR, C4BR, CD35, KNNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P17927Complement receptor type 12,0397Ensembl, GeneID, HGNCUniProt

Patents 28

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777528 A12026-07-2225P17927Espacenet
JP 2026053563 A2026-03-258P17927Espacenet
US 12544423 B22026-02-101P17927Espacenet
JP 2026501750 A2026-01-161P17927Espacenet
KR 1020250163297 A2025-11-201P17927Espacenet
JP 2025529142 A2025-09-041109P17927Espacenet
US 12383600 B22025-08-121P17927Espacenet
US 12371689 B22025-07-291109P17927Espacenet
JP 2025062601 A2025-04-149P17927Espacenet
EP 4512822 A22025-02-261P17927Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
MIROCOCEPTCHEMBL2108040Complement receptor type 1 inhibitorINHIBITORChEMBL

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4405

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)1192,025NIH's project files
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions292,025NIH's project files
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study262,025NIH's project files
P30CA008748Cancer Center Support Grant252,025NIH's project files
R01NS017950Precursors of Stroke Incidence and Prognosis162,025NIH's project files
U24AG041689THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE162,025NIH's project files
U24AG056270National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)162,025NIH's project files
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)132,025NIH's project files
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies122,025NIH's project files
P30AG072975Rush Alzheimer's Disease Research Center112,025NIH's project files

Papers 7844

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825454PubTator, text miningPubMed
42812306PubTator, text miningPubMed
42799816PubTator, text miningPubMed
42794823PubTator, text miningPubMed
42783847PubTator, text miningPubMed
42755516PubTator, text miningPubMed
42746023PubTator, text miningPubMed
42700121PubTator, text miningPubMed
42640163PubTator, text miningPubMed
42520338PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license