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Gene · 1390

CREM: cAMP responsive element modulator

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CREM: cAMP responsive element modulator. Genes, record 1390. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1390

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Gene

Symbol
CREM
HGNC
Name
cAMP responsive element modulator
HGNC
NCBI Gene ID
1390
NCBI Gene
HGNC ID
HGNC:2352
HGNC
Ensembl
ENSG00000095794
NCBI Gene
Aliases
CREM-2, ICER, hCREM-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q03060cAMP-responsive element modulator3450Ensembl, GeneID, HGNC

Source UniProt

Patents7

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439872Q03060Espacenet
JP 2025062604 A2025-04-1411361Q03060Espacenet
US 11446398 B22022-09-2011361Q03060Espacenet
JP 2022524081 A2022-04-27114332Q03060Espacenet
JP 2019054813 A2019-04-11220307Q03060Espacenet
JP 2017121241 A2017-07-13220307Q03060Espacenet
JP 2015516143 A2015-06-08220307Q03060Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,201

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCREM papersNewest fiscal year
R01AI049954Gene Transcription in SLE242025
P30CA008748Cancer Center Support Grant102025
R01AI085567Expanded Double Negative T cells in SLE.102025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital72025
P50CA217694SPORE in Soft Tissue Sarcoma52025
P30AR070549Cincinnati Rheumatic Diseases Resource Center42025
P30CA016672Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P51OD011092Support for National Primate Research Center32025
R01AR063759Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state32025

1 to 10 of 1,201Source NIH's project files

See all 1,201 nih grants

Papers1,658

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Gene-Based Rare Variant Burden Analyses Across Biobanks Identify Novel High-Risk Genes for Thoracic Aortic Disease.medRxiv202642818172PubTator, text miningPubMed
A comprehensive full-length transcriptome landscape of cigarette smoke-exposed HASMCs reveals extensive remodeling of mRNA isoforms and regulatory networks.PLoS One202642766668PubTator, text miningPubMed
Aging microenvironment induces CD8+ T cell exhaustion by suppressing hepatic β-hydroxybutyrylate synthesis.Cell Metab202642692017PubTator, text miningPubMed
CREM Marks TCR-Driven T-Cell Activation and Associates with Favorable Prognosis in Papillary Thyroid Carcinoma: A Single-Cell and Bulk Transcriptomic Study.Int J Mol Sci202642653390PubTator, text miningPubMed
CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across diverse cell types.bioRxiv202642619677PubTator, text miningPubMed
PGE2-mediated NK cell reprogramming drives acquired immunotherapy resistance in lung adenocarcinoma.J Immunother Cancer202642586608PubTator, text miningPubMed
Immune cells harbor their own microbiome-derived metabolome: a new layer of immunometabolic regulation.Front Immunol202642582102PubTator, text miningPubMed
The CREM-IL-15 axis: decoding the persistence-exhaustion paradox in NK cell immunotherapy.Cancer Immunol Immunother202642550263PubTator, text miningPubMed
Clinicopathologic characteristics of uterine malignant epithelioid neoplasms with EWSR1::CREM fusion: Report of 2 cases at a novel site with literature review.Virchows Arch202642360471PubTator, text miningPubMed
[Cutaneous clear cell sarcoma].Pathologie (Heidelb)202642307723PubTator, text miningPubMed

1 to 10 of 1,658

See all 1,658 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1390

GET https://conductscience.org/api/genes/v1/1390/grants?page=2