Gene · 1390
CREM: cAMP responsive element modulator
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CREM: cAMP responsive element modulator. Genes, record 1390. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1390
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q03060 | cAMP-responsive element modulator | 345 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents7
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 39872 | Q03060 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 11361 | Q03060 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 11361 | Q03060 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 114332 | Q03060 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 220307 | Q03060 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 220307 | Q03060 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 220307 | Q03060 | Espacenet |
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,201
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CREM papers | Newest fiscal year |
|---|---|---|---|
| R01AI049954 | Gene Transcription in SLE | 24 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| R01AI085567 | Expanded Double Negative T cells in SLE. | 10 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 7 | 2025 |
| P50CA217694 | SPORE in Soft Tissue Sarcoma | 5 | 2025 |
| P30AR070549 | Cincinnati Rheumatic Diseases Resource Center | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| P51OD011092 | Support for National Primate Research Center | 3 | 2025 |
| R01AR063759 | Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state | 3 | 2025 |
1 to 10 of 1,201Source NIH's project files
See all 1,201 nih grantsPapers1,658
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Gene-Based Rare Variant Burden Analyses Across Biobanks Identify Novel High-Risk Genes for Thoracic Aortic Disease. | medRxiv | 2026 | 42818172 | PubTator, text mining | PubMed |
| A comprehensive full-length transcriptome landscape of cigarette smoke-exposed HASMCs reveals extensive remodeling of mRNA isoforms and regulatory networks. | PLoS One | 2026 | 42766668 | PubTator, text mining | PubMed |
| Aging microenvironment induces CD8+ T cell exhaustion by suppressing hepatic β-hydroxybutyrylate synthesis. | Cell Metab | 2026 | 42692017 | PubTator, text mining | PubMed |
| CREM Marks TCR-Driven T-Cell Activation and Associates with Favorable Prognosis in Papillary Thyroid Carcinoma: A Single-Cell and Bulk Transcriptomic Study. | Int J Mol Sci | 2026 | 42653390 | PubTator, text mining | PubMed |
| CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across diverse cell types. | bioRxiv | 2026 | 42619677 | PubTator, text mining | PubMed |
| PGE2-mediated NK cell reprogramming drives acquired immunotherapy resistance in lung adenocarcinoma. | J Immunother Cancer | 2026 | 42586608 | PubTator, text mining | PubMed |
| Immune cells harbor their own microbiome-derived metabolome: a new layer of immunometabolic regulation. | Front Immunol | 2026 | 42582102 | PubTator, text mining | PubMed |
| The CREM-IL-15 axis: decoding the persistence-exhaustion paradox in NK cell immunotherapy. | Cancer Immunol Immunother | 2026 | 42550263 | PubTator, text mining | PubMed |
| Clinicopathologic characteristics of uterine malignant epithelioid neoplasms with EWSR1::CREM fusion: Report of 2 cases at a novel site with literature review. | Virchows Arch | 2026 | 42360471 | PubTator, text mining | PubMed |
| [Cutaneous clear cell sarcoma]. | Pathologie (Heidelb) | 2026 | 42307723 | PubTator, text mining | PubMed |
1 to 10 of 1,658
See all 1,658 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1390
GET https://conductscience.org/api/genes/v1/1390/grants?page=2