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Gene · 139341

FUNDC1: FUN14 domain containing 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FUNDC1: FUN14 domain containing 1. Genes, record 139341. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/139341

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Gene

Symbol
FUNDC1
HGNC
Name
FUN14 domain containing 1
HGNC
NCBI Gene ID
139341
NCBI Gene
HGNC ID
HGNC:28746
HGNC
Ensembl
ENSG00000069509
NCBI Gene
Aliases
MGC51029
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IVP5FUN14 domain-containing protein 11552Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025024198 A2025-02-1912691Q8IVP5Espacenet
US 11446398 B22022-09-2033075Q8IVP5Espacenet
JP 2022524081 A2022-04-27136046Q8IVP5Espacenet
US 11078247 B22021-08-034223Q8IVP5Espacenet
JP 2021018154 A2021-02-15652Q8IVP5Espacenet
WO 2020043864 A12020-03-05937Q8IVP5Espacenet
US 9827332 B22017-11-2812691Q8IVP5Espacenet
JP 2017121243 A2017-07-1356659Q8IVP5Espacenet
US 9254311 B22016-02-0912691Q8IVP5Espacenet
JP 2015513912 A2015-05-1856659Q8IVP5Espacenet

1 to 10 of 14

See all 14 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants580

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFUNDC1 papersNewest fiscal year
P30AG028740University of Florida Older Americans Independence Center (OAIC)32025
P30DK020579Diabetes Research Center32025
R01CA142746Subcellular enzyme-instructed self-assembly for molecular anticancer nanomedicines32025
R01CA200310BNIP3 and BNIP3L (NIX) in lipid homeostasis and growth control in the liver32025
R01DE016572Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy32025
R01DK079879Autophagy in liver injury32025
R01HL091469Cysteine oxidation in the heart32025
R01NS101628Dendrite regulation by the mitochondrial kinase PINK1: Implications for PD/LBD32025
R35GM131919The mechanism and regulation of autophagy32025
T32CA009594Multi-Disciplinary Training Grant in Cancer Research32025

1 to 10 of 580Source NIH's project files

See all 580 nih grants

Papers1,296

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Bibliometric Review of Research Trends and Therapeutic Potential Reveals Natural Products as Major Regulators of Mitophagy in Kidney Disease.Mini Rev Med Chem202642817106PubTator, text miningPubMed
SRC Promotes High Glucose-Induced Retinal Endothelial Dysfunction by Suppressing FUNDC1-Mediated Mitophagy in Diabetic Retinopathy.Curr Eye Res202642806608PubTator, text miningPubMed
Transcriptional Regulation of Receptor-Mediated Mitophagy in Sunitinib-Resistant Renal Cancer Cells: Response to Succinic Acid.Pharmaceuticals (Basel)202642797377PubTator, text miningPubMed
FUNDC1 Attenuates UVA-Induced Skin Photoaging by Regulating Mitophagy and P53 Stability.Antioxidants (Basel)202642792104PubTator, text miningPubMed
Mitophagy in idiopathic pulmonary fibrosis: from molecular mechanisms to therapeutic opportunities.Front Cell Dev Biol202642769024PubTator, text miningPubMed
Mitophagy as an active regulator of cardiac metabolic reprogramming.Front Cardiovasc Med202642746169PubTator, text miningPubMed
Piezo1 as a Key Mechanosensitive Ion Channel Linking Mechanical Overload to Mitochondrial Dysfunction, Mitophagy, and Immunometabolic Dysregulation in Osteoarthritis.Cells202642738805PubTator, text miningPubMed
Targeting FUNDC1 Enhances Radiosensitivity of Esophageal Squamous Cell Carcinoma by Suppressing Mitochondrial Function.Curr Gene Ther202642634168PubTator, text miningPubMed
Transcriptomic and genetic evidence highlights EHHADH in a FUNDC1-associated mitochondrial network in diabetic nephropathy.Metabol Open202642633340PubTator, text miningPubMed
Upregulation of serum circular RNA FUNDC1 and TNF-α in Behçet's disease: potential diagnostic biomarkers.Sci Rep202642632834PubTator, text miningPubMed

1 to 10 of 1,296

See all 1,296 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/139341

GET https://conductscience.org/api/genes/v1/139341/patents