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Gene · 1394

CRHR1: corticotropin releasing hormone receptor 1

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. CRHR1: corticotropin releasing hormone receptor 1. Genes, record 1394. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/1394

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
CRHR1
HGNC
Name
corticotropin releasing hormone receptor 1
HGNC
NCBI Gene ID
1394
NCBI Gene
HGNC ID
HGNC:2357
HGNC
Ensembl
ENSG00000120088
NCBI Gene
Aliases
CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P34998Corticotropin-releasing hormone receptor 141511Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442297P34998Espacenet
EP 4650780 A22025-11-195643P34998Espacenet
JP 2025147176 A2025-10-063508P34998Espacenet
JP 2025517970 A2025-06-125643P34998Espacenet
JP 2025028160 A2025-02-283508P34998Espacenet
KR 1020250010750 A2025-01-213508P34998Espacenet
JP 2024109657 A2024-08-143515P34998Espacenet
US 11446398 B22022-09-2020046P34998Espacenet
US 11446398 B22022-09-2020055P34998Espacenet
US 11446398 B22022-09-2020064P34998Espacenet

1 to 10 of 53

See all 53 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CRINECERFONTCHEMBL291657Corticotropin releasing factor receptor 1 antagonistANTAGONISTChEMBL
EMICERFONTCHEMBL514270Corticotropin releasing factor receptor 1 antagonistANTAGONISTChEMBL
ONO-2333MSCHEMBL1819077Corticotropin releasing factor receptor 1 antagonistANTAGONISTChEMBL
PEXACERFONTCHEMBL482950Corticotropin releasing factor receptor 1 antagonistANTAGONISTChEMBL
VERUCERFONTCHEMBL1287935Corticotropin releasing factor receptor 1 antagonistANTAGONISTChEMBL

Trials20

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07536269CRINECERFONTPHASE2ClinicalTrials.gov
NCT07187375CRINECERFONTPHASE2ClinicalTrials.gov
NCT04806451CRINECERFONTPHASE32025-02-05ClinicalTrials.gov
NCT04490915CRINECERFONTPHASE32025-02-05ClinicalTrials.gov
NCT04045145CRINECERFONTPHASE22024-07-18ClinicalTrials.gov
NCT03525886CRINECERFONTPHASE22022-05-03ClinicalTrials.gov
NCT02349503VERUCERFONTPHASE1ClinicalTrials.gov
NCT01814332VERUCERFONTPHASE22016-04-25ClinicalTrials.gov
NCT01227980PEXACERFONTPHASE22015-12-10ClinicalTrials.gov
NCT01187511VERUCERFONTPHASE22016-11-07ClinicalTrials.gov

1 to 10 of 20

See all 20 trials

NIH grants3,689

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology462025
U01AA0134989/10 Electrophysiology of Alcohol in Extended Amygdala172025
R37AA017447Gene-environment interaction: the brain CRF system in alcohol preferring msP rats162025
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders152025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).142025
ZIAAA000301Integrative genetics of behavior with high throughput technologies142025
P60AA010760Behavioral Genomics of Alcohol Neuroadaptation132025
T32AA007456NEUROPSYCHOPHARMACOLOGY: MULTIDISCIPLINARY TRAINING132025
P51OD011092Support for National Primate Research Center92025
T32AA007573Molecular and Cellular Alcohol Research Training92025

1 to 10 of 3,689Source NIH's project files

See all 3,689 nih grants

Papers4,392

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42808100PubTator, text miningPubMed
42716024PubTator, text miningPubMed
42665478PubTator, text miningPubMed
42639844PubTator, text miningPubMed
42602249PubTator, text miningPubMed
42582797PubTator, text miningPubMed
42550679PubTator, text miningPubMed
42471538PubTator, text miningPubMed
42460153PubTator, text miningPubMed
42395519PubTator, text miningPubMed

1 to 10 of 4,392

See all 4,392 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1394

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