ConductScience.org, home

Gene · 1398

CRK: CRK proto-oncogene, adaptor protein

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. CRK: CRK proto-oncogene, adaptor protein. Genes, record 1398. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1398

On this page

Gene

Symbol
CRK
HGNC
Name
CRK proto-oncogene, adaptor protein
HGNC
NCBI Gene ID
1398
NCBI Gene
HGNC ID
HGNC:2362
HGNC
Ensembl
ENSG00000167193
NCBI Gene
Aliases
CRKII, p38
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P46108Adapter molecule crk30410Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025539788 A2025-12-093P46108Espacenet
EP 4650780 A22025-11-194009P46108Espacenet
EP 4619546 A12025-09-245P46108Espacenet
KR 1020250105394 A2025-07-083P46108Espacenet
JP 2025517970 A2025-06-124009P46108Espacenet
JP 2024123008 A2024-09-108955P46108Espacenet
KR 1020240072368 A2024-05-243P46108Espacenet
JP 2023123507 A2023-09-05245P46108Espacenet
US 11685954 B22023-06-2781P46108Espacenet
US 11685954 B22023-06-2785P46108Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,895

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCRK papersNewest fiscal year
P30CA016672Cancer Center Support Grant132025
P30CA008748Cancer Center Support Grant122025
P30CA006927Comprehensive Cancer Center Program at Fox Chase92025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant72025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE62025
P30CA015704Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant52025
I01BX003741Optimization of therapeutic mAbs to carbapenem resistant Klebsiella clone ST25842025
P30CA044579University of Virginia Cancer Center Support Grant42025
P50CA126752SPORE in Lymphoma42025

1 to 10 of 1,895Source NIH's project files

See all 1,895 nih grants

Papers2,784

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Crk/Crk-L-mediated Rapgef1 recruitment couples MuSK signaling to AChR anchoring at the neuromuscular junction.Cell Chem Biol202642772281PubTator, text miningPubMed
Toxic mechanisms and biomarkers of Staphylococcus aureus aerosol exposure to human respiratory cells at the air-liquid interface.Environ Pollut202642457013PubTator, text miningPubMed
Systemic Drug Effects in Vortioxetine-Induced Time-Series Datasets.Int J Mol Sci202642450323PubTator, text miningPubMed
ABL kinase-dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains.FEBS Lett202642333007PubTator, text miningPubMed
A gradient of immune complexes induces directional migration and a lupus-associated transcriptional program in Slan+ non-classical monocytes.J Autoimmun202642288023PubTator, text miningPubMed
ABL kinases regulate FGF signaling independent of CRK phosphorylation to prevent Peters anomaly type II.Nat Commun202642129167PubTator, text miningPubMed
Integrin-focal adhesion-cytoskeleton signaling axis variations and genetic susceptibility to SCD-CAD.Forensic Sci Int202642114173PubTator, text miningPubMed
Midazolam and Dexmedetomidine Promoted Migration of Human Lung Adenocarcinoma A549 Cells.J Nippon Med Sch202642091510PubTator, text miningPubMed
An adaptor protein CRK mediates antiviral immunity against white spot syndrome virus via JAK/STAT signaling pathway in Cherax quadricarinatus.Fish Shellfish Immunol202642009210PubTator, text miningPubMed
Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations.FASEB J202641930605PubTator, text miningPubMed

1 to 10 of 2,784

See all 2,784 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1398

GET https://conductscience.org/api/genes/v1/1398/patents?page=2