Gene · 1398
CRK: CRK proto-oncogene, adaptor protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CRK: CRK proto-oncogene, adaptor protein. Genes, record 1398. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1398
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P46108 | Adapter molecule crk | 304 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025539788 A | 2025-12-09 | 3 | P46108 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4009 | P46108 | Espacenet |
| EP 4619546 A1 | 2025-09-24 | 5 | P46108 | Espacenet |
| KR 1020250105394 A | 2025-07-08 | 3 | P46108 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4009 | P46108 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8955 | P46108 | Espacenet |
| KR 1020240072368 A | 2024-05-24 | 3 | P46108 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 245 | P46108 | Espacenet |
| US 11685954 B2 | 2023-06-27 | 81 | P46108 | Espacenet |
| US 11685954 B2 | 2023-06-27 | 85 | P46108 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,895
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CRK papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 9 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 7 | 2025 |
| P20GM103449 | Vermont Biomedical Research Network-Vermont INBRE | 6 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| I01BX003741 | Optimization of therapeutic mAbs to carbapenem resistant Klebsiella clone ST258 | 4 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 4 | 2025 |
| P50CA126752 | SPORE in Lymphoma | 4 | 2025 |
1 to 10 of 1,895Source NIH's project files
See all 1,895 nih grantsPapers2,784
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Crk/Crk-L-mediated Rapgef1 recruitment couples MuSK signaling to AChR anchoring at the neuromuscular junction. | Cell Chem Biol | 2026 | 42772281 | PubTator, text mining | PubMed |
| Toxic mechanisms and biomarkers of Staphylococcus aureus aerosol exposure to human respiratory cells at the air-liquid interface. | Environ Pollut | 2026 | 42457013 | PubTator, text mining | PubMed |
| Systemic Drug Effects in Vortioxetine-Induced Time-Series Datasets. | Int J Mol Sci | 2026 | 42450323 | PubTator, text mining | PubMed |
| ABL kinase-dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains. | FEBS Lett | 2026 | 42333007 | PubTator, text mining | PubMed |
| A gradient of immune complexes induces directional migration and a lupus-associated transcriptional program in Slan+ non-classical monocytes. | J Autoimmun | 2026 | 42288023 | PubTator, text mining | PubMed |
| ABL kinases regulate FGF signaling independent of CRK phosphorylation to prevent Peters anomaly type II. | Nat Commun | 2026 | 42129167 | PubTator, text mining | PubMed |
| Integrin-focal adhesion-cytoskeleton signaling axis variations and genetic susceptibility to SCD-CAD. | Forensic Sci Int | 2026 | 42114173 | PubTator, text mining | PubMed |
| Midazolam and Dexmedetomidine Promoted Migration of Human Lung Adenocarcinoma A549 Cells. | J Nippon Med Sch | 2026 | 42091510 | PubTator, text mining | PubMed |
| An adaptor protein CRK mediates antiviral immunity against white spot syndrome virus via JAK/STAT signaling pathway in Cherax quadricarinatus. | Fish Shellfish Immunol | 2026 | 42009210 | PubTator, text mining | PubMed |
| Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations. | FASEB J | 2026 | 41930605 | PubTator, text mining | PubMed |
1 to 10 of 2,784
See all 2,784 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1398
GET https://conductscience.org/api/genes/v1/1398/patents?page=2