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Gene · 1399

CRKL: CRK like proto-oncogene, adaptor protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CRKL: CRK like proto-oncogene, adaptor protein. Genes, record 1399. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1399

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Gene

Symbol
CRKL
HGNC
Name
CRK like proto-oncogene, adaptor protein
HGNC
NCBI Gene ID
1399
NCBI Gene
HGNC ID
HGNC:2363
HGNC
Ensembl
ENSG00000099942
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P46109Crk-like protein3036Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469613P46109Espacenet
JP 2026004568 A2026-01-1469614P46109Espacenet
EP 4650780 A22025-11-197055P46109Espacenet
EP 4589011 A12025-07-231P46109Espacenet
JP 2025517970 A2025-06-127055P46109Espacenet
JP 2025038035 A2025-03-184490P46109Espacenet
EP 4484957 A12025-01-0122P46109Espacenet
US 12134655 B22024-11-054490P46109Espacenet
WO 2024058178 A2024-03-211P46109Espacenet
WO 2023162878 A2023-08-3122P46109Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,558

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCRKL papersNewest fiscal year
P30CA016672Cancer Center Support Grant272025
P30CA008748Cancer Center Support Grant222025
P30CA042014Cancer Center Support Grant92025
P30CA021765Cancer Center Support Grant (CCSG)82025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant82025
P50CA217694SPORE in Soft Tissue Sarcoma72025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE62025
P30CA015704Cancer Center Support Grant62025
P30CA046934University of Colorado Cancer Center Support Grant62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025

1 to 10 of 1,558Source NIH's project files

See all 1,558 nih grants

Papers2,191

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Crk/Crk-L-mediated Rapgef1 recruitment couples MuSK signaling to AChR anchoring at the neuromuscular junction.Cell Chem Biol202642772281PubTator, text miningPubMed
DepPrior: integrating CRISPR dependency predictability with multi-omics reproducibility to prioritize candidate LUAD therapeutic targets.Front Pharmacol202642761694PubTator, text miningPubMed
SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics.Int J Mol Sci202642589701PubTator, text miningPubMed
Expression and prognostic significance of CRKL in clear cell renal cell carcinoma.Am J Clin Exp Immunol202642487720PubTator, text miningPubMed
Multi-layer network biology combined with single-cell evidence reveals core regulatory nodes in atherosclerotic plaques and potential drug-targeting directions.Naunyn Schmiedebergs Arch Pharmacol202642410224PubTator, text miningPubMed
CRKL amplification synergizes with mechanical stress-induced signaling to dually activate YAP oncogenic pathways, driving plantar melanoma progression.Apoptosis202642334626PubTator, text miningPubMed
ABL kinase-dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains.FEBS Lett202642333007PubTator, text miningPubMed
Effect of food intake on biomarkers measured by the Proseek Multiplex Metabolism panel.Clin Physiol Funct Imaging202642145186PubTator, text miningPubMed
Targeting RANKL-independent osteoclastogenesis overcomes denosumab resistance in models of ER+ breast cancer bone metastasis.J Clin Invest202642138086PubTator, text miningPubMed
ABL kinases regulate FGF signaling independent of CRK phosphorylation to prevent Peters anomaly type II.Nat Commun202642129167PubTator, text miningPubMed

1 to 10 of 2,191

See all 2,191 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1399

GET https://conductscience.org/api/genes/v1/1399/patents?page=2