Gene · 1399
CRKL: CRK like proto-oncogene, adaptor protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CRKL: CRK like proto-oncogene, adaptor protein. Genes, record 1399. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1399
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P46109 | Crk-like protein | 303 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 69613 | P46109 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 69614 | P46109 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7055 | P46109 | Espacenet |
| EP 4589011 A1 | 2025-07-23 | 1 | P46109 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7055 | P46109 | Espacenet |
| JP 2025038035 A | 2025-03-18 | 4490 | P46109 | Espacenet |
| EP 4484957 A1 | 2025-01-01 | 22 | P46109 | Espacenet |
| US 12134655 B2 | 2024-11-05 | 4490 | P46109 | Espacenet |
| WO 2024058178 A | 2024-03-21 | 1 | P46109 | Espacenet |
| WO 2023162878 A | 2023-08-31 | 22 | P46109 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,558
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CRKL papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 27 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 22 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 9 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 8 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 8 | 2025 |
| P50CA217694 | SPORE in Soft Tissue Sarcoma | 7 | 2025 |
| P20GM103449 | Vermont Biomedical Research Network-Vermont INBRE | 6 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 6 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 6 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 5 | 2025 |
1 to 10 of 1,558Source NIH's project files
See all 1,558 nih grantsPapers2,191
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Crk/Crk-L-mediated Rapgef1 recruitment couples MuSK signaling to AChR anchoring at the neuromuscular junction. | Cell Chem Biol | 2026 | 42772281 | PubTator, text mining | PubMed |
| DepPrior: integrating CRISPR dependency predictability with multi-omics reproducibility to prioritize candidate LUAD therapeutic targets. | Front Pharmacol | 2026 | 42761694 | PubTator, text mining | PubMed |
| SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics. | Int J Mol Sci | 2026 | 42589701 | PubTator, text mining | PubMed |
| Expression and prognostic significance of CRKL in clear cell renal cell carcinoma. | Am J Clin Exp Immunol | 2026 | 42487720 | PubTator, text mining | PubMed |
| Multi-layer network biology combined with single-cell evidence reveals core regulatory nodes in atherosclerotic plaques and potential drug-targeting directions. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42410224 | PubTator, text mining | PubMed |
| CRKL amplification synergizes with mechanical stress-induced signaling to dually activate YAP oncogenic pathways, driving plantar melanoma progression. | Apoptosis | 2026 | 42334626 | PubTator, text mining | PubMed |
| ABL kinase-dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains. | FEBS Lett | 2026 | 42333007 | PubTator, text mining | PubMed |
| Effect of food intake on biomarkers measured by the Proseek Multiplex Metabolism panel. | Clin Physiol Funct Imaging | 2026 | 42145186 | PubTator, text mining | PubMed |
| Targeting RANKL-independent osteoclastogenesis overcomes denosumab resistance in models of ER+ breast cancer bone metastasis. | J Clin Invest | 2026 | 42138086 | PubTator, text mining | PubMed |
| ABL kinases regulate FGF signaling independent of CRK phosphorylation to prevent Peters anomaly type II. | Nat Commun | 2026 | 42129167 | PubTator, text mining | PubMed |
1 to 10 of 2,191
See all 2,191 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1399
GET https://conductscience.org/api/genes/v1/1399/patents?page=2