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Gene · 1406

CRX: cone-rod homeobox

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CRX: cone-rod homeobox. Genes, record 1406. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1406

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Gene

Symbol
CRX
HGNC
Name
cone-rod homeobox
HGNC
NCBI Gene ID
1406
NCBI Gene
HGNC ID
HGNC:2383
HGNC
Ensembl
ENSG00000105392
NCBI Gene
Aliases
CORD2, CRD, LCA7, OTX3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43186Cone-rod homeobox protein2991Ensembl, GeneID, HGNC

Source UniProt

Patents65

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19273O43186Espacenet
JP 2026004568 A2026-01-1442170O43186Espacenet
JP 2026004568 A2026-01-1442172O43186Espacenet
JP 2026004568 A2026-01-1442173O43186Espacenet
JP 2026004568 A2026-01-1442174O43186Espacenet
EP 4667578 A22025-12-2455O43186Espacenet
EP 4640849 A22025-10-2962O43186Espacenet
EP 4641201 A22025-10-29378O43186Espacenet
JP 2025147176 A2025-10-0614852O43186Espacenet
JP 2025131621 A2025-09-0955O43186Espacenet

1 to 10 of 65

See all 65 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,250

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCRX papersNewest fiscal year
R01EY012543Vulnerable and Resilient Cells in Retinal Degeneration452025
ZIAEY000450Genetic and epigenetic regulation of retinal development, aging and evolution212025
R01EY018213Defining Barriers to Gene Therapy122025
T32EY013360Interdisciplinary Training in Vision Science122025
P30EY022589NEI Center Core Grant for Vision Research112025
R01EY032136Understanding and treating CRX-linked retinopathies112025
P30EY001730Vision Research Core102025
ZIAEY000546Mechanisms, modeling and therapies of retinal and macular neurodegeneration102025
R01EY018571Genetics of early onset retinal diseases92025
R01GM092910Analysis of combinatorial cis-regulation in synthetic and genomic promoters92025

1 to 10 of 1,250Source NIH's project files

See all 1,250 nih grants

Papers1,885

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Evolution of MAF and OTX families during the emergence and stabilization of rod photoreceptors across Metazoans.Res Sq202642818957PubTator, text miningPubMed
Reporter-guided photoreceptor differentiation in 2D culture using PGP1-hIPSCs: A comparable alternative to 3D organoid systems?Mol Vis202642774032PubTator, text miningPubMed
Sporadic Retinal Astrocytic Hamartoma Mimicking Retinoblastoma in a Child: A Case Report and Literature Review.Clin Case Rep202642701388PubTator, text miningPubMed
Intrafamilial phenotypic variability in CRX-associated retinopathy due to a frameshift variant (c.661del).Ophthalmic Genet202642675935PubTator, text miningPubMed
Dissecting Missing Heritability in Rare Inherited Macular Dystrophies.Genes (Basel)202642650171PubTator, text miningPubMed
Structure and Quantitative-Structure-Function Relationships of Wheat High-Molecular-Weight Glutenin Subunits: From Allelic Polymorphism to Dough Rheology.Compr Rev Food Sci Food Saf202642548237PubTator, text miningPubMed
EXCAVATE-HT: A Bioinformatic Pipeline to Identify Targetable Genomic Variants for Allele-Specific Editing.bioRxiv202642539204PubTator, text miningPubMed
Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses.EBioMedicine202642481375PubTator, text miningPubMed
A CRX-positive RB1-deficient bone tumour with a retinoblastoma-like DNA methylation profile.Histopathology202642365976PubTator, text miningPubMed
Blue cone monochromacy with parafoveal hyperautofluorescent ring caused by a novel OPN1LW p.Ile109Asn variant.Doc Ophthalmol202642274835PubTator, text miningPubMed

1 to 10 of 1,885

See all 1,885 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1406

GET https://conductscience.org/api/genes/v1/1406/patents?page=2