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Gene · 1407

CRY1: cryptochrome circadian regulator 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CRY1: cryptochrome circadian regulator 1. Genes, record 1407. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1407

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Gene

Symbol
CRY1
HGNC
Name
cryptochrome circadian regulator 1
HGNC
NCBI Gene ID
1407
NCBI Gene
HGNC ID
HGNC:2384
HGNC
Ensembl
ENSG00000008405
NCBI Gene
Aliases
DSPD, PHLL1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16526Cryptochrome-15860Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1933Q16526Espacenet
EP 4641201 A22025-10-2926Q16526Espacenet
JP 2025517969 A2025-06-1226Q16526Espacenet
JP 2025517970 A2025-06-1233Q16526Espacenet
JP 2025032204 A2025-03-1126830Q16526Espacenet
EP 4461818 A22024-11-1326830Q16526Espacenet
JP 2024123008 A2024-09-105676Q16526Espacenet
JP 2023058610 A2023-04-2526830Q16526Espacenet
US 11446398 B22022-09-2020229Q16526Espacenet
JP 2022524081 A2022-04-27123200Q16526Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,657

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCRY1 papersNewest fiscal year
P30CA014195Cancer Center Support Grant (CCSG)92025
P30ES010126UNC Center for Environmental Health and Susceptibility72025
R01CA211187CIRCADIAN REGULATION OF HIF2alpha IN ccRCC72025
R01DK090625Integration of Feeding Time and Glucose Metabolism by the Circadian Gene Network72025
R35GM118102Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock72025
R01AG039547Circadian Clock and Dietary Restriction52025
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis52025
R35GM127122Molecular mechanisms of mammalian circadian clock function - Renewal - 152025
IK6BX004601BLR&D Research Career Scientist Award42025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 1,657Source NIH's project files

See all 1,657 nih grants

Papers2,635

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diurnal Insulin Clearance and Circadian Metabolic Gene Signatures in MASLD: Integrative Multi-Dataset Physiological and Transcriptomic Analysis.Metabolites202642783754PubTator, text miningPubMed
SETDB1 cooperates with the CRL4B complex to promote colorectal cancer tumorigenesis by disrupting circadian rhythm.Oncogene202642778664PubTator, text miningPubMed
The circadian clock component NPAS2 is modulated by AMPK and regulates substrate utilization and mitochondrial function in human skeletal muscle cells.Mol Metab202642762975PubTator, text miningPubMed
The relationship of peripheral circadian gene mRNAs, antisense lncRNAs, and serum protein levels with chronotype, biological, and social rhythm in euthymic patients with bipolar disorder.Chronobiol Int202642693835PubTator, text miningPubMed
Integrated Clinical-Molecular Risk Stratification in Diffuse Large B-Cell Lymphoma: Machine Learning Survival Analysis.JMIR Med Inform202642627678PubTator, text miningPubMed
Insomnia-Associated Circadian and Thrombotic Alterations Coincide with Morning Cardiac Vulnerability.ACS Pharmacol Transl Sci202642614672PubTator, text miningPubMed
The Human Circadian Clock Protein Cryptochrome-1 Responds to Photochemistry by Conformational Changes.J Am Chem Soc202642584628PubTator, text miningPubMed
Circadian Disruption as a Determinant of the Tumor Temporal State in Colorectal Cancer: A PRISMA-Based Systematic Review Integrating Metabolism, Immunity, and Metastasis.Int J Mol Sci202642511510PubTator, text miningPubMed
Reference Genes for Circadian Profiling of Core Clock Genes in the Blood of Obstructive Sleep Apnea Patients.Biomolecules202642509806PubTator, text miningPubMed
Impact of Core Circadian Gene Variants on Glycemic Parameters and Insulin Resistance in Type 2 Diabetes: A Systematic Review.Cureus202642504374PubTator, text miningPubMed

1 to 10 of 2,635

See all 2,635 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1407

GET https://conductscience.org/api/genes/v1/1407/patents?page=2