Gene · 1408
CRY2: cryptochrome circadian regulator 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CRY2: cryptochrome circadian regulator 2. Genes, record 1408. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1408
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q49AN0 | Cryptochrome-2 | 593 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents17
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 18888 | Q49AN0 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3556 | Q49AN0 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6019 | Q49AN0 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6019 | Q49AN0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 18888 | Q49AN0 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 3556 | Q49AN0 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 3556 | Q49AN0 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 3563 | Q49AN0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 20234 | Q49AN0 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 123205 | Q49AN0 | Espacenet |
1 to 10 of 17
See all 17 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,072
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CRY2 papers | Newest fiscal year |
|---|---|---|---|
| P30DA018343 | Yale/NIDA Neuroproteomics Center | 8 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 8 | 2025 |
| R01DK090625 | Integration of Feeding Time and Glucose Metabolism by the Circadian Gene Network | 8 | 2025 |
| R35GM122567 | Near-infrared fluorescent probes and optogenetic tools | 8 | 2025 |
| R01CA211187 | CIRCADIAN REGULATION OF HIF2alpha IN ccRCC | 7 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 6 | 2025 |
| R01CA051497 | Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis | 6 | 2025 |
| R35GM118102 | Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock | 6 | 2025 |
| R35GM138211 | Harnessing protein clustering to understand, identify, and manipulate cellular systems | 5 | 2025 |
1 to 10 of 2,072Source NIH's project files
See all 2,072 nih grantsPapers2,922
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Optogenetic Evidence for the Intrinsic Phase Separation Propensity of the Sgs1 N-Terminal Region: Implications for Assemblysome Formation. | Biomolecules | 2026 | 42793072 | PubTator, text mining | PubMed |
| The circadian clock component NPAS2 is modulated by AMPK and regulates substrate utilization and mitochondrial function in human skeletal muscle cells. | Mol Metab | 2026 | 42762975 | PubTator, text mining | PubMed |
| Elucidating shared genetic signals between type 2 diabetes and three neurodegenerative dementia phenotypes. | HGG Adv | 2026 | 42681870 | PubTator, text mining | PubMed |
| Protocol to determine oligomerization states of proteins in living cells using photon counting histogram analysis. | STAR Protoc | 2026 | 42560811 | PubTator, text mining | PubMed |
| Prognostic risk modeling based on integrated multi-omics analysis identifies CRY2 as a key regulator in tumor immunity and patient survival in colorectal cancer. | Ann Med | 2026 | 42550740 | PubTator, text mining | PubMed |
| The role of neuronal protein NOS in regulation of magnetic orientation in the subterranean termite Odontotermes formosanus. | Insect Mol Biol | 2026 | 42533218 | PubTator, text mining | PubMed |
| Impact of Core Circadian Gene Variants on Glycemic Parameters and Insulin Resistance in Type 2 Diabetes: A Systematic Review. | Cureus | 2026 | 42504374 | PubTator, text mining | PubMed |
| Mathematical mapping of circadian genes in Alzheimer's disease. | Chronobiol Int | 2026 | 42483877 | PubTator, text mining | PubMed |
| PIP2 stabilizes NaV1.5 gating and links receptor signaling to cardiac late sodium current. | bioRxiv | 2026 | 42427782 | PubTator, text mining | PubMed |
| Blood leukocyte DNA methylation of circadian genes in relation to environmental phthalate exposure in Mexican adolescents. | Environ Res | 2026 | 42392437 | PubTator, text mining | PubMed |
1 to 10 of 2,922
See all 2,922 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1408
GET https://conductscience.org/api/genes/v1/1408/patents