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Gene · 1408

CRY2: cryptochrome circadian regulator 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CRY2: cryptochrome circadian regulator 2. Genes, record 1408. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1408

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Gene

Symbol
CRY2
HGNC
Name
cryptochrome circadian regulator 2
HGNC
NCBI Gene ID
1408
NCBI Gene
HGNC ID
HGNC:2385
HGNC
Ensembl
ENSG00000121671
NCBI Gene
Aliases
HCRY2, PHLL2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q49AN0Cryptochrome-25930Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1918888Q49AN0Espacenet
JP 2025147176 A2025-10-063556Q49AN0Espacenet
JP 2025529142 A2025-09-046019Q49AN0Espacenet
US 12371689 B22025-07-296019Q49AN0Espacenet
JP 2025517970 A2025-06-1218888Q49AN0Espacenet
JP 2025028160 A2025-02-283556Q49AN0Espacenet
KR 1020250010750 A2025-01-213556Q49AN0Espacenet
JP 2024109657 A2024-08-143563Q49AN0Espacenet
US 11446398 B22022-09-2020234Q49AN0Espacenet
JP 2022524081 A2022-04-27123205Q49AN0Espacenet

1 to 10 of 17

See all 17 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,072

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCRY2 papersNewest fiscal year
P30DA018343Yale/NIDA Neuroproteomics Center82025
P30DK045735Yale Diabetes Research Center82025
R01DK090625Integration of Feeding Time and Glucose Metabolism by the Circadian Gene Network82025
R35GM122567Near-infrared fluorescent probes and optogenetic tools82025
R01CA211187CIRCADIAN REGULATION OF HIF2alpha IN ccRCC72025
P30CA014195Cancer Center Support Grant (CCSG)62025
P30ES010126UNC Center for Environmental Health and Susceptibility62025
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis62025
R35GM118102Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock62025
R35GM138211Harnessing protein clustering to understand, identify, and manipulate cellular systems52025

1 to 10 of 2,072Source NIH's project files

See all 2,072 nih grants

Papers2,922

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Optogenetic Evidence for the Intrinsic Phase Separation Propensity of the Sgs1 N-Terminal Region: Implications for Assemblysome Formation.Biomolecules202642793072PubTator, text miningPubMed
The circadian clock component NPAS2 is modulated by AMPK and regulates substrate utilization and mitochondrial function in human skeletal muscle cells.Mol Metab202642762975PubTator, text miningPubMed
Elucidating shared genetic signals between type 2 diabetes and three neurodegenerative dementia phenotypes.HGG Adv202642681870PubTator, text miningPubMed
Protocol to determine oligomerization states of proteins in living cells using photon counting histogram analysis.STAR Protoc202642560811PubTator, text miningPubMed
Prognostic risk modeling based on integrated multi-omics analysis identifies CRY2 as a key regulator in tumor immunity and patient survival in colorectal cancer.Ann Med202642550740PubTator, text miningPubMed
The role of neuronal protein NOS in regulation of magnetic orientation in the subterranean termite Odontotermes formosanus.Insect Mol Biol202642533218PubTator, text miningPubMed
Impact of Core Circadian Gene Variants on Glycemic Parameters and Insulin Resistance in Type 2 Diabetes: A Systematic Review.Cureus202642504374PubTator, text miningPubMed
Mathematical mapping of circadian genes in Alzheimer's disease.Chronobiol Int202642483877PubTator, text miningPubMed
PIP2 stabilizes NaV1.5 gating and links receptor signaling to cardiac late sodium current.bioRxiv202642427782PubTator, text miningPubMed
Blood leukocyte DNA methylation of circadian genes in relation to environmental phthalate exposure in Mexican adolescents.Environ Res202642392437PubTator, text miningPubMed

1 to 10 of 2,922

See all 2,922 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1408

GET https://conductscience.org/api/genes/v1/1408/patents