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PARP1: poly(ADP-ribose) polymerase 1

1 protein, 79 patents, 14 drugs, 820 trials, 15,744 NIH grants and 54,665 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPARP1HGNC
Namepoly(ADP-ribose) polymerase 1HGNC
NCBI Gene ID142NCBI Gene
HGNC IDHGNC:270HGNC
EnsemblENSG00000143799NCBI Gene
AliasesADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PARS, PPOL, Poly-PARP, pADPRT-1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P09874Poly [ADP-ribose] polymerase 11,014106Ensembl, GeneID, HGNCUniProt

Patents 79

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458311P09874Espacenet
EP 4641201 A22025-10-298258P09874Espacenet
JP 2025147176 A2025-10-0615454P09874Espacenet
JP 2025517969 A2025-06-128258P09874Espacenet
WO 2025056690 A12025-03-201P09874Espacenet
JP 2025028160 A2025-02-2815454P09874Espacenet
KR 1020250010750 A2025-01-2115454P09874Espacenet
EP 4464338 A22024-11-20148P09874Espacenet
JP 2024109657 A2024-08-1415293P09874Espacenet
US 11976334 B22024-05-07175P09874Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
2X-121CHEMBL3644587Poly [ADP-ribose] polymerase-1 inhibitorINHIBITORChEMBL
AMELPARIBCHEMBL3649803Poly [ADP-ribose] polymerase-1 inhibitorINHIBITORChEMBL
AMELPARIB DIHYDROCHLORIDE DIHYDRATECHEMBL5314421Poly [ADP-ribose] polymerase-1 inhibitorINHIBITORChEMBL
E-7016CHEMBL3527000PARP 1, 2 and 3 inhibitorINHIBITORChEMBL
NIRAPARIBCHEMBL1094636Poly [ADP-ribose] polymerase-1 inhibitorINHIBITORChEMBL
NIRAPARIB TOSYLATE MONOHYDRATECHEMBL3989922Poly [ADP-ribose] polymerase-1 inhibitorINHIBITORChEMBL
OLAPARIBCHEMBL521686PARP 1, 2 and 3 inhibitorINHIBITORChEMBL
PAMIPARIBCHEMBL4112930Poly [ADP-ribose] polymerase-1 inhibitorINHIBITORChEMBL
RUCAPARIBCHEMBL1173055PARP 1, 2 and 3 inhibitorINHIBITORChEMBL
RUCAPARIB CAMSYLATECHEMBL3833368PARP 1, 2 and 3 inhibitorINHIBITORChEMBL

Trials 820

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07586449SENAPARIBClinicalTrials.gov
NCT07486687OLAPARIBPHASE3ClinicalTrials.gov
NCT07460180OLAPARIBPHASE1/PHASE2ClinicalTrials.gov
NCT07407452OLAPARIBPHASE2ClinicalTrials.gov
NCT07371104OLAPARIBPHASE1ClinicalTrials.gov
NCT07187674OLAPARIBClinicalTrials.gov
NCT07151911OLAPARIBClinicalTrials.gov
NCT07120451SENAPARIBPHASE2ClinicalTrials.gov
NCT07113964OLAPARIBPHASE2ClinicalTrials.gov
NCT07090369OLAPARIBPHASE1ClinicalTrials.gov

NIH grants 15744

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant5192,025NIH's project files
P30CA008748Cancer Center Support Grant3592,025NIH's project files
P01CA092584Structural Cell Biology of DNA Repair Machines1182,025NIH's project files
P30CA047904Cancer Center Support Grant1052,025NIH's project files
P30CA006973Regional Oncology Research Center892,025NIH's project files
P30CA016058Cancer Center Support Grant642,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028612,025NIH's project files
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs572,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase562,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant552,025NIH's project files

Papers 54665

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826577PubTator, text miningPubMed
42822289PubTator, text miningPubMed
42821287PubTator, text miningPubMed
42820288PubTator, text miningPubMed
42819173PubTator, text miningPubMed
42818383PubTator, text miningPubMed
42818220PubTator, text miningPubMed
42818163PubTator, text miningPubMed
42816376PubTator, text miningPubMed
42814605PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license