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MAPK14: mitogen-activated protein kinase 14

1 protein, 114 patents, 37 drugs, 92 trials, 20,334 NIH grants and 61,315 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMAPK14HGNC
Namemitogen-activated protein kinase 14HGNC
NCBI Gene ID1432NCBI Gene
HGNC IDHGNC:6876HGNC
EnsemblENSG00000112062NCBI Gene
AliasesCSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, p38alphaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q16539Mitogen-activated protein kinase 14360267Ensembl, GeneID, HGNCUniProt

Patents 114

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0348Q16539Espacenet
EP 4650780 A22025-11-19749Q16539Espacenet
EP 4641201 A22025-10-29529Q16539Espacenet
JP 2025517969 A2025-06-12529Q16539Espacenet
JP 2025517970 A2025-06-12749Q16539Espacenet
US 12252709 B22025-03-1822Q16539Espacenet
US 12133879 B22024-11-0548Q16539Espacenet
JP 2024123008 A2024-09-107041Q16539Espacenet
US 11920164 B22024-03-0540Q16539Espacenet
JP 2024012295 A2024-01-301Q16539Espacenet

Drugs 37

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACUMAPIMODCHEMBL5314397MAP kinase p38 alpha inhibitorINHIBITORChEMBL
AMG-548CHEMBL585902MAP kinase p38 alpha inhibitorINHIBITORChEMBL
ARRY-797CHEMBL1088750MAP kinase p38 alpha inhibitorINHIBITORChEMBL
AVE-9940CHEMBL3545117MAP kinase p38 alpha inhibitorINHIBITORChEMBL
AZD-6703CHEMBL2031465MAP kinase p38 alpha inhibitorINHIBITORChEMBL
AZD-7624CHEMBL9960MAP kinase p38 alpha inhibitorINHIBITORChEMBL
BMS-582949CHEMBL1230065MAP kinase p38 alpha inhibitorINHIBITORChEMBL
DILMAPIMODCHEMBL2103838MAP kinase p38 alpha inhibitorINHIBITORChEMBL
DORAMAPIMODCHEMBL103667MAP kinase p38 alpha inhibitorINHIBITORChEMBL
FX-005CHEMBL3545216MAP kinase p38 alpha inhibitorINHIBITORChEMBL

Trials 92

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07033481NEFLAMAPIMODPHASE2ClinicalTrials.gov
NCT06815965NEFLAMAPIMODPHASE2ClinicalTrials.gov
NCT05869669NEFLAMAPIMODPHASE2ClinicalTrials.gov
NCT05659459PAMAPIMODPHASE2ClinicalTrials.gov
NCT05397470LOSMAPIMODPHASE32025-11-10ClinicalTrials.gov
NCT04511819LOSMAPIMODPHASE32024-03-13ClinicalTrials.gov
NCT04264442LOSMAPIMODPHASE22025-09-30ClinicalTrials.gov
NCT04074967PEXMETINIBPHASE1/PHASE2ClinicalTrials.gov
NCT04004000LOSMAPIMODPHASE22025-12-02ClinicalTrials.gov
NCT04003974LOSMAPIMODPHASE22024-07-10ClinicalTrials.gov

NIH grants 20334

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2122,025NIH's project files
P30CA008748Cancer Center Support Grant802,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center372,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant342,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award342,025NIH's project files
P30CA016058Cancer Center Support Grant332,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant332,025NIH's project files
P30CA068485Cancer Center Support Grant302,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases302,025NIH's project files
P30CA047904Cancer Center Support Grant282,025NIH's project files

Papers 61315

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826913PubTator, text miningPubMed
42822860PubTator, text miningPubMed
42822143PubTator, text miningPubMed
42818202PubTator, text miningPubMed
42811980PubTator, text miningPubMed
42811977PubTator, text miningPubMed
42811434PubTator, text miningPubMed
42808783PubTator, text miningPubMed
42807534PubTator, text miningPubMed
42805422PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license