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Gene · 143384

CACUL1: CDK2 associated cullin domain 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CACUL1: CDK2 associated cullin domain 1. Genes, record 143384. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/143384

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Gene

Symbol
CACUL1
HGNC
Name
CDK2 associated cullin domain 1
HGNC
NCBI Gene ID
143384
NCBI Gene
HGNC ID
HGNC:23727
HGNC
Ensembl
ENSG00000151893
NCBI Gene
Aliases
C10orf46, CAC1, FLJ40409, MGC33215
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q86Y37CDK2-associated and cullin domain-containing protein 13690Ensembl, GeneID, HGNC

Source UniProt

Patents9

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025024198 A2025-02-199879Q86Y37Espacenet
US 11446398 B22022-09-2013466Q86Y37Espacenet
JP 2022524081 A2022-04-27116437Q86Y37Espacenet
US 11078247 B22021-08-031515Q86Y37Espacenet
US 9827332 B22017-11-289879Q86Y37Espacenet
JP 2017121243 A2017-07-1353847Q86Y37Espacenet
KR 1020170045539 A2017-04-278Q86Y37Espacenet
US 9254311 B22016-02-099879Q86Y37Espacenet
JP 2015513912 A2015-05-1853847Q86Y37Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,498

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACUL1 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)352025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control272025
P30CA008748Cancer Center Support Grant232025
P30CA016086Cancer Center Support Grant152025
P30CA016672Cancer Center Support Grant142025
P40OD010440Caenorhabditis Genetics Center112025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202892025
R01CA240981Harnessing E3 Ligases for Cancer Therapy92025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias82025
P30CA044579University of Virginia Cancer Center Support Grant82025

1 to 10 of 2,498Source NIH's project files

See all 2,498 nih grants

Papers3,620

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MLN4924 suppresses kidney renal clear cell carcinoma progression through coordinated inhibition of Cullin1 neddylation and PSMB10-associated NF-κB inflammatory signaling.Inflamm Res202642802181PubTator, text miningPubMed
L013 promotes NRF2 degradation in NRFA-subtype esophageal squamous cell carcinoma.Cell Rep Med202642727581PubTator, text miningPubMed
Neddylation as a molecular integrator of metabolic dysfunction and endothelial dysfunction in type 2 diabetes.Acta Pharmacol Sin202642637928PubTator, text miningPubMed
Neddylation-dependent RAB40-Cullin5 E3 ligase complex controls ubiquitin-mediated proteasomal degradation of DNAJC13.BBA Adv202642602476PubTator, text miningPubMed
Structure-Based Discovery of JN210 as a Potent Dual DCN1/HDAC Inhibitor for the Treatment of Nonsmall Cell Lung Cancer.J Med Chem202642593931PubTator, text miningPubMed
Evidence that S-phase kinase associated protein 2 (SKP2) is ubiquitinated and degraded via a Rho-related BTB domain containing 1 (RhoBTB1) and Cullin-3 mechanism in placenta.Physiol Rep202642552612PubTator, text miningPubMed
CACUL1 promotes hepatocellular carcinoma progression through enhanced tumor cell proliferation and macrophage-mediated immune suppression.Front Immunol202642535029PubTator, text miningPubMed
Genome-Wide Characterization of the F-Box Gene Family in Cardamine hupingshanensis and Functional Analysis of ChFBX171.Biology (Basel)202642450551PubTator, text miningPubMed
E3 ligase LMO7 promotes ALKBH2 ubiquitination to sensitize MGMT-deficient glioblastoma to temozolomide.Cell Death Dis202642380110PubTator, text miningPubMed
Native Mass Spectrometry Analysis of Cullin-RING Ubiquitin E3 Ligase Complexes in the Context of Targeted Protein Degradation.Anal Chem202642378227PubTator, text miningPubMed

1 to 10 of 3,620

See all 3,620 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/143384

GET https://conductscience.org/api/genes/v1/143384/grants?page=2