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Gene · 143471

PSMA8: proteasome 20S subunit alpha 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMA8: proteasome 20S subunit alpha 8. Genes, record 143471. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/143471

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Gene

Symbol
PSMA8
HGNC
Name
proteasome 20S subunit alpha 8
HGNC
NCBI Gene ID
143471
NCBI Gene
HGNC ID
HGNC:22985
HGNC
Ensembl
ENSG00000154611
NCBI Gene
Aliases
MGC26605, PSMA7L
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TAA3Proteasome subunit alpha-type 82560Ensembl, GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-294303Q8TAA3Espacenet
JP 2025517969 A2025-06-124303Q8TAA3Espacenet
US 11564998 B22023-01-315286Q8TAA3Espacenet
US 11446398 B22022-09-2067895Q8TAA3Espacenet
JP 2022524081 A2022-04-27170866Q8TAA3Espacenet
US 10463751 B22019-11-055286Q8TAA3Espacenet
JP 2018023373 A2018-02-1528013Q8TAA3Espacenet
US 9572897 B22017-02-215286Q8TAA3Espacenet
US 9303079 B22016-04-055286Q8TAA3Espacenet
JP 2015519040 A2015-07-0928013Q8TAA3Espacenet

1 to 10 of 13

See all 13 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants99

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMA8 papersNewest fiscal year
P30CA008748Cancer Center Support Grant22025
P30CA016042Cancer Center Support Grant12025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202812025
P30CA091842Cancer Center Support Grant12025
P30ES023515Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)12025
P50CA116201Mayo Clinic Breast Cancer SPORE12025
R01ES026033Organic-metal mixtures and neurodevelopment12025
R01HD088412Functional analysis of novel testis-expressed secreted and transmembrane proteins12025
R01HL118761Pitx2 in atrial fibrillation12025
R35GM122480Proteomics and model organism humanization to decode human genetics12025

1 to 10 of 99Source NIH's project files

See all 99 nih grants

Papers141

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Phenotyping of post-fertilization sperm mitophagy determinants discovered in a mammalian gamete-based cell-free system.Biol Res202642366378PubTator, text miningPubMed
The synaptonemal complex: structure, function, and clinical implications†.Biol Reprod202642059593PubTator, text miningPubMed
Integrative analysis of the PSMA family identifies PSMA6 as an adverse prognostic biomarker promoting bladder cancer cell proliferation.Int J Med Sci202641799753PubTator, text miningPubMed
The constitutive 20S proteasome is required for the maintenance and differentiation of spermatogonia in mice.J Adv Res202641167419PubTator, text miningPubMed
Prediction of Immunotherapy Response and Prognostic Outcomes for Patients With Ovarian Cancer Using PANoptosis-Related Genes.Hum Mutat202541141246PubTator, text miningPubMed
Single nucleus transcriptome of a "Super RV" shows increased insulin and angiogenesis signaling.bioRxiv202438196630PubTator, text miningPubMed
Dissecting the genetic variations associated with response to first-line chemotherapy in patients with small cell lung cancer: a retrospective cohort study.J Thorac Dis202338249933PubTator, text miningPubMed
Editorial for the Special Issue "Genetics and Genomics of Gastrointestinal Cancers: From Prevention to Treatment".Genes (Basel)202337761961PubTator, text miningPubMed
Adhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer.Sci Rep202337684377PubTator, text miningPubMed
Synaptonemal Complex in Human Biology and Disease.Cells202337443752PubTator, text miningPubMed

1 to 10 of 141

See all 141 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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