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Gene · 1452

CSNK1A1: casein kinase 1 alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CSNK1A1: casein kinase 1 alpha 1. Genes, record 1452. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1452

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Gene

Symbol
CSNK1A1
HGNC
Name
casein kinase 1 alpha 1
HGNC
NCBI Gene ID
1452
NCBI Gene
HGNC ID
HGNC:2451
HGNC
Ensembl
ENSG00000113712
NCBI Gene
Aliases
CK1, CK1a, CK1alpha, CKIa, CKIalpha, HEL-S-77p, HLCDGP1, PRO2975
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48729Casein kinase I isoform alpha3375Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440152P48729Espacenet
EP 4650780 A22025-11-199974P48729Espacenet
JP 2025517970 A2025-06-129974P48729Espacenet
JP 2025062604 A2025-04-1412054P48729Espacenet
EP 4522752 A12025-03-1917P48729Espacenet
EP 4490275 A12025-01-157P48729Espacenet
US 11785925 B22023-10-1713P48729Espacenet
US 11446398 B22022-09-2012054P48729Espacenet
JP 2022524081 A2022-04-27115025P48729Espacenet
US 11168345 B22021-11-095P48729Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,666

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCSNK1A1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
R01CA214608The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase162025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias132025
R35GM122516Maximizing Investigators' Research Award (R35 - Clinical Trial Optional)122025
P30CA008748Cancer Center Support Grant112025
P30CA076292Moffitt Cancer Center Support Grant102025
P30DK058404Molecular and Cellular Basis for Digestive Diseases92025
R01CA218278Degrading therapeutically important kinases using small molecules82025
P30CA016058Cancer Center Support Grant72025
P30CA021765Cancer Center Support Grant (CCSG)72025

1 to 10 of 1,666Source NIH's project files

See all 1,666 nih grants

Papers2,578

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Chemical regulation of circadian rhythms through inhibition of casein kinase Iδ and α.Biochem Biophys Res Commun202642810220PubTator, text miningPubMed
Midazolam Reduces Metabolic Viability and Induces Apoptosis in MIA PaCa-2 Pancreatic Cancer Cells with Selective Transcriptional Modulation of Wnt and Hedgehog Components: A Preliminary In Vitro Study.
Pharmaceuticals (Basel)202642797517PubTator, text miningPubMed
Systematic Analysis of MRTFB Phosphoproteomic Datasets Reveals Co-Regulated Kinase Networks and Co-Occurring Phosphosites Associated with the Actin Cytoskeleton Pathway.Curr Issues Mol Biol202642793267PubTator, text miningPubMed
Lenalidomide Exposure and TP53-Mutated Myelodysplastic Syndromes/Neoplasms.Curr Oncol202642782853PubTator, text miningPubMed
Csnk1a1 E98 mutations rewire signaling and metabolism in del(5q) myelodysplastic neoplasms.Leukemia202642693162PubTator, text miningPubMed
Casein Kinase 1 Alpha 1 Is Over-expressed in Pancreatic Adenocarcinoma Tissues and Correlates With Shorter Patient Survival.Cancer Diagn Progn202642682938PubTator, text miningPubMed
CCT8 associates with the MYO10 motor domain and regulates filopodia and breast cancer cell invasion.J Cell Sci202642677351PubTator, text miningPubMed
Discovery of molecular glue degrader for treatment of IMiDs-resistant multiple myeloma based on GLUT-mediated tumor targeting strategy.Bioorg Chem202642561560PubTator, text miningPubMed
The kinase CK1α coordinates the initiation and termination of the cGAS-STING pathway.Cell Death Differ202642557374PubTator, text miningPubMed
A Selective CK1α Degrader Targets Acute Myeloid Leukemia and Spares Normal Hematopoietic Cells.Cancer Res202642545171PubTator, text miningPubMed

1 to 10 of 2,578

See all 2,578 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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