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Gene · 1454

CSNK1E: casein kinase 1 epsilon

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CSNK1E: casein kinase 1 epsilon. Genes, record 1454. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1454

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Gene

Symbol
CSNK1E
HGNC
Name
casein kinase 1 epsilon
HGNC
NCBI Gene ID
1454
NCBI Gene
HGNC ID
HGNC:2453
HGNC
Ensembl
ENSG00000213923
NCBI Gene
Aliases
CKIE, CKIe, CKIepsilon, HCKIE
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49674Casein kinase I isoform epsilon4162Ensembl, GeneID, HGNC

Source UniProt

Patents87

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12540940 B22026-02-039P49674Espacenet
JP 2026004568 A2026-01-1440159P49674Espacenet
JP 2026004568 A2026-01-1440161P49674Espacenet
JP 2026004568 A2026-01-1440162P49674Espacenet
JP 2026004568 A2026-01-1440163P49674Espacenet
JP 2026004568 A2026-01-1440164P49674Espacenet
EP 4650780 A22025-11-197720P49674Espacenet
JP 2025517970 A2025-06-127720P49674Espacenet
JP 2025062604 A2025-04-1412076P49674Espacenet
JP 2025062604 A2025-04-1412077P49674Espacenet

1 to 10 of 87

See all 87 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
UMBRALISIBCHEMBL3948730Casein kinase I epsilon inhibitorINHIBITORChEMBL
UMBRALISIB TOSYLATECHEMBL3989869Casein kinase I epsilon inhibitorINHIBITORChEMBL

Trials36

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05152459UMBRALISIBPHASE1/PHASE2ClinicalTrials.gov
NCT04783415UMBRALISIBPHASE22023-11-18ClinicalTrials.gov
NCT04692155UMBRALISIBPHASE1/PHASE22023-09-28ClinicalTrials.gov
NCT04635683UMBRALISIBPHASE1ClinicalTrials.gov
NCT04624633UMBRALISIBPHASE22025-02-27ClinicalTrials.gov
NCT04508647UMBRALISIBPHASE22023-11-09ClinicalTrials.gov
NCT04163718UMBRALISIBPHASE22023-03-24ClinicalTrials.gov
NCT04149821UMBRALISIBPHASE22023-06-15ClinicalTrials.gov
NCT04016805UMBRALISIBPHASE22023-07-24ClinicalTrials.gov
NCT03919175UMBRALISIBPHASE22026-02-27ClinicalTrials.gov

1 to 10 of 36

See all 36 trials

NIH grants1,028

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCSNK1E papersNewest fiscal year
P30CA042014Cancer Center Support Grant92025
P30CA076292Moffitt Cancer Center Support Grant42025
P30CA023108Cancer Center Support Grant32025
P30CA196521The Tisch Cancer Institute - Cancer Center Support Grant32025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)32025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025
P30CA006516Dana-Farber/Harvard Cancer Center22025
P30CA008748Cancer Center Support Grant22025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)22025

1 to 10 of 1,028Source NIH's project files

See all 1,028 nih grants

Papers1,127

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TAGLN2 promotes mesenchymal circulating tumor cell-associated metastasis through the CSNK1E-YAP Axis with concomitant EMT induction and metabolic remodeling in hepatocellular carcinoma.Cell Signal202642600715PubTator, text miningPubMed
Meta-cancer phosphoproteomic analysis unveils association of Tau phosphosites with DNA damage response.Front Syst Biol202642254072PubTator, text miningPubMed
CSNK1E as a key to unlocking drug persistence in DLBCL.Blood202642207551PubTator, text miningPubMed
Site-Specific Phosphoproteomic Profiling of CAV1 Reveals Co-Regulatory Kinase Networks in Cancer Signaling.Int J Mol Sci202642196307PubTator, text miningPubMed
Comprehensive Analysis of Core Genes, Key Pathways, and Immune Infiltration in Intervertebral Disc Degeneration Using Machine Learning and Experimental Validation.Iran J Allergy Asthma Immunol202642130144PubTator, text miningPubMed
Duvelisib upregulates p27 expression and leads to intestinal damage via the NEDD4L/CK1ε axis.Biochem Pharmacol202641905427PubTator, text miningPubMed
Comprehensive bioinformatics analysis and experimental validation reveal the role of circadian rhythm-related genes in the crosstalk between osteoporosis and atherosclerosis.Mamm Genome202641896290PubTator, text miningPubMed
The Hippo pathway in clear cell renal cell carcinoma (ccRCC): a nexus with the VHL disruption?Transl Oncol202641764979PubTator, text miningPubMed
CSNK1E sustains stemlike drug persistence in diffuse large B-cell lymphoma.Blood202641758931PubTator, text miningPubMed
ReMeDy: A Flexible Statistical Framework For Region-based Detection of DNA Methylation Dysregulation.bioRxiv202641743983PubTator, text miningPubMed

1 to 10 of 1,127

See all 1,127 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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