Gene · 1454
CSNK1E: casein kinase 1 epsilon
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CSNK1E: casein kinase 1 epsilon. Genes, record 1454. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1454
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49674 | Casein kinase I isoform epsilon | 416 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents87
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12540940 B2 | 2026-02-03 | 9 | P49674 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40159 | P49674 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40161 | P49674 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40162 | P49674 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40163 | P49674 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40164 | P49674 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7720 | P49674 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7720 | P49674 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12076 | P49674 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12077 | P49674 | Espacenet |
1 to 10 of 87
See all 87 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials36
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05152459 | UMBRALISIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT04783415 | UMBRALISIB | PHASE2 | 2023-11-18 | ClinicalTrials.gov |
| NCT04692155 | UMBRALISIB | PHASE1/PHASE2 | 2023-09-28 | ClinicalTrials.gov |
| NCT04635683 | UMBRALISIB | PHASE1 | ClinicalTrials.gov | |
| NCT04624633 | UMBRALISIB | PHASE2 | 2025-02-27 | ClinicalTrials.gov |
| NCT04508647 | UMBRALISIB | PHASE2 | 2023-11-09 | ClinicalTrials.gov |
| NCT04163718 | UMBRALISIB | PHASE2 | 2023-03-24 | ClinicalTrials.gov |
| NCT04149821 | UMBRALISIB | PHASE2 | 2023-06-15 | ClinicalTrials.gov |
| NCT04016805 | UMBRALISIB | PHASE2 | 2023-07-24 | ClinicalTrials.gov |
| NCT03919175 | UMBRALISIB | PHASE2 | 2026-02-27 | ClinicalTrials.gov |
1 to 10 of 36
See all 36 trialsNIH grants1,028
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CSNK1E papers | Newest fiscal year |
|---|---|---|---|
| P30CA042014 | Cancer Center Support Grant | 9 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 4 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 3 | 2025 |
| P30CA196521 | The Tisch Cancer Institute - Cancer Center Support Grant | 3 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 3 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 3 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 3 | 2025 |
| P30CA006516 | Dana-Farber/Harvard Cancer Center | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 2 | 2025 |
1 to 10 of 1,028Source NIH's project files
See all 1,028 nih grantsPapers1,127
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| TAGLN2 promotes mesenchymal circulating tumor cell-associated metastasis through the CSNK1E-YAP Axis with concomitant EMT induction and metabolic remodeling in hepatocellular carcinoma. | Cell Signal | 2026 | 42600715 | PubTator, text mining | PubMed |
| Meta-cancer phosphoproteomic analysis unveils association of Tau phosphosites with DNA damage response. | Front Syst Biol | 2026 | 42254072 | PubTator, text mining | PubMed |
| CSNK1E as a key to unlocking drug persistence in DLBCL. | Blood | 2026 | 42207551 | PubTator, text mining | PubMed |
| Site-Specific Phosphoproteomic Profiling of CAV1 Reveals Co-Regulatory Kinase Networks in Cancer Signaling. | Int J Mol Sci | 2026 | 42196307 | PubTator, text mining | PubMed |
| Comprehensive Analysis of Core Genes, Key Pathways, and Immune Infiltration in Intervertebral Disc Degeneration Using Machine Learning and Experimental Validation. | Iran J Allergy Asthma Immunol | 2026 | 42130144 | PubTator, text mining | PubMed |
| Duvelisib upregulates p27 expression and leads to intestinal damage via the NEDD4L/CK1ε axis. | Biochem Pharmacol | 2026 | 41905427 | PubTator, text mining | PubMed |
| Comprehensive bioinformatics analysis and experimental validation reveal the role of circadian rhythm-related genes in the crosstalk between osteoporosis and atherosclerosis. | Mamm Genome | 2026 | 41896290 | PubTator, text mining | PubMed |
| The Hippo pathway in clear cell renal cell carcinoma (ccRCC): a nexus with the VHL disruption? | Transl Oncol | 2026 | 41764979 | PubTator, text mining | PubMed |
| CSNK1E sustains stemlike drug persistence in diffuse large B-cell lymphoma. | Blood | 2026 | 41758931 | PubTator, text mining | PubMed |
| ReMeDy: A Flexible Statistical Framework For Region-based Detection of DNA Methylation Dysregulation. | bioRxiv | 2026 | 41743983 | PubTator, text mining | PubMed |
1 to 10 of 1,127
See all 1,127 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1454
GET https://conductscience.org/api/genes/v1/1454/patents?page=2