Gene · 1457
CSNK2A1: casein kinase 2 alpha 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CSNK2A1: casein kinase 2 alpha 1. Genes, record 1457. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1457
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P68400 | Casein kinase II subunit alpha | 391 | 321 | Ensembl, GeneID, HGNC |
Source UniProt
Patents126
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 383 | P68400 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 383 | P68400 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12122 | P68400 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12123 | P68400 | Espacenet |
| EP 4480961 A1 | 2024-12-25 | 94 | P68400 | Espacenet |
| EP 4433492 A1 | 2024-09-25 | 8 | P68400 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5291 | P68400 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 5292 | P68400 | Espacenet |
| EP 4403581 A1 | 2024-07-24 | 2 | P68400 | Espacenet |
| JP 2024527193 A | 2024-07-22 | 40 | P68400 | Espacenet |
1 to 10 of 126
See all 126 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| SILMITASERTIB | CHEMBL1230165 | Casein kinase II alpha inhibitor | INHIBITOR |
Source ChEMBL
Trials6
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04668209 | SILMITASERTIB | PHASE2 | 2023-08-14 | ClinicalTrials.gov |
| NCT04663737 | SILMITASERTIB | PHASE2 | 2024-12-16 | ClinicalTrials.gov |
| NCT03897036 | SILMITASERTIB | PHASE1 | 2025-05-20 | ClinicalTrials.gov |
| NCT02128282 | SILMITASERTIB | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT01199718 | SILMITASERTIB | PHASE1 | ClinicalTrials.gov | |
| NCT00891280 | SILMITASERTIB | PHASE1 | ClinicalTrials.gov |
NIH grants2,181
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CSNK2A1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 6 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 5 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| ZIASC010357 | Gene Expression and Post-Transcriptional Regulation of DNA Tumor Viruses | 5 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 4 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 4 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 2,181Source NIH's project files
See all 2,181 nih grantsPapers3,014
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Phosphorylation destabilizes Per3 to promote gallbladder carcinoma. | Exp Cell Res | 2026 | 42777803 | PubTator, text mining | PubMed |
| Phosphorylated HPV‑16 E7 disrupts planar cell polarity in cervical cancer cells through vangl1 dysregulation. | PLoS Pathog | 2026 | 42766580 | PubTator, text mining | PubMed |
| Broadening the Okur-Chung syndrome phenotype: adult-onset metabolic features and a contiguous 20p13 deletion in a Turkish multicenter cohort. | J Hum Genet | 2026 | 42706398 | PubTator, text mining | PubMed |
| Correction to "A Case of CSNK2A1 Gene Variant Causing Okur-Chung Syndrome and Analysis of the Clinical Phenotypic Spectrum". | Mol Genet Genomic Med | 2026 | 42587398 | PubTator, text mining | PubMed |
| A Temporal Phospho-acetylome Atlas of Human Myogenesis Identifies coordinated Post-Translational Regulation. | Mol Cell Proteomics | 2026 | 42392363 | PubTator, text mining | PubMed |
| Sleep profiles in individuals with rare neurogenetic syndromes. | Dev Med Child Neurol | 2026 | 42338150 | PubTator, text mining | PubMed |
| Systems-level multi-omics dissection of syndromic and idiopathic autism reveals distinct regulatory architectures, candidate molecular signatures, and potential therapeutic targets. | Comput Biol Med | 2026 | 42330854 | PubTator, text mining | PubMed |
| Establishment and validation of a novel anoikis-related prognostic signature of lung squamous cell carcinoma. | Transl Cancer Res | 2026 | 42180924 | PubTator, text mining | PubMed |
| Subtype-Independent Activation of NF-κB Signaling in Breast Cancer. | Int J Mol Sci | 2026 | 42123635 | PubTator, text mining | PubMed |
| Evaluating splicing factor and kinase network crosstalk through global phosphoproteomics. | bioRxiv | 2026 | 42079238 | PubTator, text mining | PubMed |
1 to 10 of 3,014
See all 3,014 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1457
GET https://conductscience.org/api/genes/v1/1457/patents?page=2