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Gene · 146

ADRA1D: adrenoceptor alpha 1D

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADRA1D: adrenoceptor alpha 1D. Genes, record 146. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/146

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Gene

Symbol
ADRA1D
HGNC
Name
adrenoceptor alpha 1D
HGNC
NCBI Gene ID
146
NCBI Gene
HGNC ID
HGNC:280
HGNC
Ensembl
ENSG00000171873
NCBI Gene
Aliases
ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25100Alpha-1D adrenergic receptor5720Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436845P25100Espacenet
EP 4641201 A22025-10-2910466P25100Espacenet
JP 2025529142 A2025-09-04333P25100Espacenet
US 12371689 B22025-07-29333P25100Espacenet
JP 2025517969 A2025-06-1210466P25100Espacenet
JP 2025062604 A2025-04-143466P25100Espacenet
JP 2025032204 A2025-03-1124241P25100Espacenet
EP 4461818 A22024-11-1324241P25100Espacenet
JP 2023058610 A2023-04-2524241P25100Espacenet
US 11446398 B22022-09-203466P25100Espacenet

1 to 10 of 39

See all 39 patents

Drugs68

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALFUZOSINCHEMBL709Adrenergic receptor alpha-1 agonistAGONISTChEMBL
ALFUZOSIN HYDROCHLORIDECHEMBL1723Adrenergic receptor alpha-1 agonistAGONISTChEMBL
ALSEROXYLONCHEMBL1201454Adrenergic receptor alpha antagonistANTAGONISTChEMBL
AVIPTADILCHEMBL1981592Adrenergic receptor alpha antagonistANTAGONISTChEMBL
BUCINDOLOLCHEMBL321582Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
BUCINDOLOL HYDROCHLORIDECHEMBL2107546Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
BUNAZOSINCHEMBL188185Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
CARVEDILOLCHEMBL723Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
CARVEDILOL PHOSPHATECHEMBL1201167Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
DIPIVEFRINCHEMBL1201262Adrenergic receptor agonistAGONISTChEMBL

1 to 10 of 68

See all 68 drugs

Trials753

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants909

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADRA1D papersNewest fiscal year
R01MH054137Structure and Function of Dopamine Receptors32025
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS32025
P30CA016672Cancer Center Support Grant22025
R01EY011500Structure-function studies of visual arrestin22025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors22025
ZIANS002263Molecular And Pharmacological Studies Of Dopamine Receptors22025
I01BX000740Right Heart Function in Health and Chronic Disease12025
K08AA028794Mechanisms of HIF1 alpha mediated dysregulated skeletal muscle proteostasis in alcoholic liver disease12025
K12HD000849Reproductive Scientist Development Program12025
K12HD052892Molecular Basis of Pediatric Disease12025

1 to 10 of 909Source NIH's project files

See all 909 nih grants

Papers1,547

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative predictive modelling and multi-omics validation reveals potential indicators of clinical heterogeneity in HCC.Biochem Biophys Res Commun202642759273PubTator, text miningPubMed
Liver Transplantation Prevents Emphysema Progression in Alpha-1.Chest202642716620PubTator, text miningPubMed
Roles of the phosphorylation sites of distinct α1A-adrenergic receptor domains.Mol Pharmacol202642664596PubTator, text miningPubMed
Takotsubo Cardiomyopathy With Dynamic LVOT Obstruction Mimicking Inferior STEMI.JACC Case Rep202642530183PubTator, text miningPubMed
Apiotrichum-Centered Fungal Interaction Network Disturbance Correlates With Increased Arterial Stiffness.Aging Cell202642502257PubTator, text miningPubMed
Subtype-resolved norepinephrine imaging with an engineered α1D-adrenergic receptor indicator.Cell Rep Methods202642486101PubTator, text miningPubMed
Clinical phenotypes in α1-antitrypsin deficiency: a cluster analysis on EARCO data.ERJ Open Res202642441155PubTator, text miningPubMed
Integrating Network Pharmacology and Clinical Observation to Elucidate the Therapeutic Mechanisms of Yangzheng Xiaoji Decoction in Primary Liver Cancer.Int J Gen Med202642325940PubTator, text miningPubMed
Gene Therapy: Knowledge, Attitudes, and Preferences Among Individuals with Alpha-1 Antitrypsin Deficiency.Chronic Obstr Pulm Dis202642224713PubTator, text miningPubMed
Alpha-1 Antitrypsin Replacement Improves Walking Capacity in Subjects With Severe Deficiency.Respir Care202641979019PubTator, text miningPubMed

1 to 10 of 1,547

See all 1,547 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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