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Gene · 146433

IL34: interleukin 34

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL34: interleukin 34. Genes, record 146433. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/146433

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Gene

Symbol
IL34
HGNC
Name
interleukin 34
HGNC
NCBI Gene ID
146433
NCBI Gene
HGNC ID
HGNC:28529
HGNC
Ensembl
ENSG00000157368
NCBI Gene
Aliases
C16orf77, IL-34, MGC34647
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q6ZMJ4Interleukin-342424Ensembl, GeneID, HGNC

Source UniProt

Patents141

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12570963 B22026-03-1055Q6ZMJ4Espacenet
US 12516298 B22026-01-0655Q6ZMJ4Espacenet
EP 4650780 A22025-11-193358Q6ZMJ4Espacenet
US 12473363 B22025-11-18929Q6ZMJ4Espacenet
EP 4640849 A22025-10-29411Q6ZMJ4Espacenet
EP 4641201 A22025-10-292923Q6ZMJ4Espacenet
JP 2025147176 A2025-10-067073Q6ZMJ4Espacenet
JP 2025147176 A2025-10-067074Q6ZMJ4Espacenet
JP 2025529142 A2025-09-046735Q6ZMJ4Espacenet
US 12371689 B22025-07-296735Q6ZMJ4Espacenet

1 to 10 of 141

See all 141 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,395

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL34 papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
P30AG066519The Alzheimer's Disease Research Center at the University of California, Irvine82025
P30CA013330Cancer Center Support Grant82025
R24AI059830A Xenopus Laevis Research Resource for Immunobiology72025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success62025
P30AG066444Alzheimer's Disease Research Center52025
R01CA154947Defining Pathogenic Mechanisms and Therapeutic Opportunities for Langerhans Cell Histiocytosis52025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)52025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions42025
P30CA062203Cancer Center Support Grant42025

1 to 10 of 1,395Source NIH's project files

See all 1,395 nih grants

Papers1,864

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
IL-34 in neurological homeostasis and its multifaceted roles in central nervous system diseases.Front Immunol202642761463PubTator, text miningPubMed
Increased Amyloidogenic Neuronal Injury in HIV-1-infected APP-KI Alzheimer's disease mice.Alzheimers Dement202642708464PubTator, text miningPubMed
Roles of IL-34 in neurological diseases: neuroprotection, inflammatory regulation, and myeloid plasticity.Front Immunol202642694581PubTator, text miningPubMed
Aberrant O-glycosylation Induces IL-34-Mediated Immune Remodeling and Promotes Pancreatic Cancer Progression.Cancer Res202642579812PubTator, text miningPubMed
Translational perspectives of next-generation cytokine therapies for musculoskeletal disorders.Cytokine202642571764PubTator, text miningPubMed
Innate immune response of lumpfish (Cyclopterus lumpus) to oil-based and water-soluble adjuvants.Dev Comp Immunol202642556659PubTator, text miningPubMed
An IL-34-IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression.bioRxiv202642523303PubTator, text miningPubMed
CSF1R regulates monocyte subset differentiation and intracellular metabolism.Nat Commun202642401537PubTator, text miningPubMed
Border-Associated Macrophages in CNS Health and Disease: A Comprehensive Review of Ontogeny, Heterogeneity, and Functional Plasticity at Neural Interfaces.ASN Neuro202642397694PubTator, text miningPubMed
Human IL-34 Deficiency Primes Microglia Toward Alzheimer's Disease-Associated States.medRxiv202642396292PubTator, text miningPubMed

1 to 10 of 1,864

See all 1,864 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/146433

GET https://conductscience.org/api/genes/v1/146433/patents?page=2