Gene · 146433
IL34: interleukin 34
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IL34: interleukin 34. Genes, record 146433. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/146433
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q6ZMJ4 | Interleukin-34 | 242 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents141
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12570963 B2 | 2026-03-10 | 55 | Q6ZMJ4 | Espacenet |
| US 12516298 B2 | 2026-01-06 | 55 | Q6ZMJ4 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3358 | Q6ZMJ4 | Espacenet |
| US 12473363 B2 | 2025-11-18 | 929 | Q6ZMJ4 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 411 | Q6ZMJ4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2923 | Q6ZMJ4 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 7073 | Q6ZMJ4 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 7074 | Q6ZMJ4 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6735 | Q6ZMJ4 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6735 | Q6ZMJ4 | Espacenet |
1 to 10 of 141
See all 141 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,395
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IL34 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| P30AG066519 | The Alzheimer's Disease Research Center at the University of California, Irvine | 8 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 8 | 2025 |
| R24AI059830 | A Xenopus Laevis Research Resource for Immunobiology | 7 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 6 | 2025 |
| P30AG066444 | Alzheimer's Disease Research Center | 5 | 2025 |
| R01CA154947 | Defining Pathogenic Mechanisms and Therapeutic Opportunities for Langerhans Cell Histiocytosis | 5 | 2025 |
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 5 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 4 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,395Source NIH's project files
See all 1,395 nih grantsPapers1,864
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| IL-34 in neurological homeostasis and its multifaceted roles in central nervous system diseases. | Front Immunol | 2026 | 42761463 | PubTator, text mining | PubMed |
| Increased Amyloidogenic Neuronal Injury in HIV-1-infected APP-KI Alzheimer's disease mice. | Alzheimers Dement | 2026 | 42708464 | PubTator, text mining | PubMed |
| Roles of IL-34 in neurological diseases: neuroprotection, inflammatory regulation, and myeloid plasticity. | Front Immunol | 2026 | 42694581 | PubTator, text mining | PubMed |
| Aberrant O-glycosylation Induces IL-34-Mediated Immune Remodeling and Promotes Pancreatic Cancer Progression. | Cancer Res | 2026 | 42579812 | PubTator, text mining | PubMed |
| Translational perspectives of next-generation cytokine therapies for musculoskeletal disorders. | Cytokine | 2026 | 42571764 | PubTator, text mining | PubMed |
| Innate immune response of lumpfish (Cyclopterus lumpus) to oil-based and water-soluble adjuvants. | Dev Comp Immunol | 2026 | 42556659 | PubTator, text mining | PubMed |
| An IL-34-IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression. | bioRxiv | 2026 | 42523303 | PubTator, text mining | PubMed |
| CSF1R regulates monocyte subset differentiation and intracellular metabolism. | Nat Commun | 2026 | 42401537 | PubTator, text mining | PubMed |
| Border-Associated Macrophages in CNS Health and Disease: A Comprehensive Review of Ontogeny, Heterogeneity, and Functional Plasticity at Neural Interfaces. | ASN Neuro | 2026 | 42397694 | PubTator, text mining | PubMed |
| Human IL-34 Deficiency Primes Microglia Toward Alzheimer's Disease-Associated States. | medRxiv | 2026 | 42396292 | PubTator, text mining | PubMed |
1 to 10 of 1,864
See all 1,864 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/146433
GET https://conductscience.org/api/genes/v1/146433/patents?page=2