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Gene · 147

ADRA1B: adrenoceptor alpha 1B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADRA1B: adrenoceptor alpha 1B. Genes, record 147. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/147

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Gene

Symbol
ADRA1B
HGNC
Name
adrenoceptor alpha 1B
HGNC
NCBI Gene ID
147
NCBI Gene
HGNC ID
HGNC:278
HGNC
Ensembl
ENSG00000170214
NCBI Gene
Aliases
ADRA1, ALPHA1BAR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35368Alpha-1B adrenergic receptor5200Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1019P35368Espacenet
JP 2026004568 A2026-01-1436844P35368Espacenet
JP 2025529142 A2025-09-04332P35368Espacenet
US 12371689 B22025-07-29332P35368Espacenet
JP 2025062604 A2025-04-143465P35368Espacenet
JP 2025032204 A2025-03-1124240P35368Espacenet
EP 4461818 A22024-11-1324240P35368Espacenet
JP 2023156353 A2023-10-2419P35368Espacenet
JP 2023058610 A2023-04-2524240P35368Espacenet
US 11446398 B22022-09-203465P35368Espacenet

1 to 10 of 38

See all 38 patents

Drugs67

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALFUZOSINCHEMBL709Adrenergic receptor alpha-1 agonistAGONISTChEMBL
ALFUZOSIN HYDROCHLORIDECHEMBL1723Adrenergic receptor alpha-1 agonistAGONISTChEMBL
ALSEROXYLONCHEMBL1201454Adrenergic receptor alpha antagonistANTAGONISTChEMBL
AVIPTADILCHEMBL1981592Adrenergic receptor alpha antagonistANTAGONISTChEMBL
BUCINDOLOLCHEMBL321582Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
BUCINDOLOL HYDROCHLORIDECHEMBL2107546Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
BUNAZOSINCHEMBL188185Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
CARVEDILOLCHEMBL723Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
CARVEDILOL PHOSPHATECHEMBL1201167Adrenergic receptor alpha-1 antagonistANTAGONISTChEMBL
DIPIVEFRINCHEMBL1201262Adrenergic receptor agonistAGONISTChEMBL

1 to 10 of 67

See all 67 drugs

Trials751

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,008

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADRA1B papersNewest fiscal year
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors102025
R01MH084894Function of GPCR heteromeric complexes in brain32025
I01BX000740Right Heart Function in Health and Chronic Disease22025
P30CA016672Cancer Center Support Grant22025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)22025
P51OD011132Emory National Primate Research Center22025
R35GM152056Regulation of vascular function after traumatic-hemorrhagic shock and during inflammation22025
T32GM007569Clinical Pharmacology Training Program22025
U19AI077439Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma22025
ZIADK031116Development of P2Y Receptor Ligands22025

1 to 10 of 1,008Source NIH's project files

See all 1,008 nih grants

Papers1,256

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Local sympathetic signal enables the immune evasion of hepatic stellate cells.Neuron202642748918PubTator, text miningPubMed
α 1A-Adrenergic receptor (ADRA1A) signaling signatures as prognostic biomarkers in liver hepatocellular carcinoma: a bioinformatic analysis.In Silico Pharmacol202642542688PubTator, text miningPubMed
Neuroticism is linked to cognitive decline and increased risk of Alzheimer's disease through dysregulation of excitatory neurons.bioRxiv202642427719PubTator, text miningPubMed
Potential Cardiovascular Risks of Phenethylamine Analogues in Food Supplements: Evidence from Vasocontraction of Rat Artery Segments.Cardiovasc Toxicol202641934574PubTator, text miningPubMed
Molecular Boolean analyses of chemokine (C-C motif) receptor 1, α1B-adrenoceptor and arginine vasopressin receptor 1A heteromers.Biochem Biophys Rep202641867271PubTator, text miningPubMed
Synergistic Effect of Combination Treatment of Brexpiprazole and Nalmefene on Ethanol Intake in Rats.Neuropsychopharmacol Rep202641793049PubTator, text miningPubMed
Health risk analysis of micro-and nanoplastic exposure via the microbiota-gut-brain axis.Front Immunol202641789083PubTator, text miningPubMed
Exploring the Impact of E‑Waste Exposure on Childhood Blood Pressure: Metabolomics Analysis and Risk Prediction.Environ Health (Wash)202641743803PubTator, text miningPubMed
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective.Immun Inflamm Dis202641725222PubTator, text miningPubMed
Somatic Mutations Profiling in Genes Other than BRCA and TP53 Increasing Breast Carcinoma Risk Among Pakistani Patients.Rev Recent Clin Trials202640755100PubTator, text miningPubMed

1 to 10 of 1,256

See all 1,256 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/147

GET https://conductscience.org/api/genes/v1/147/patents?page=2